Mental health first aid training and assessment for healthcare professionals and medical nursing students: a systematic review.

Purpose: To summarize the effect of mental health first aid (MHFA) on paramedics and medical nursing students and provide direction to future training and research.

Methods: Seven databases, including Web of Science, PubMed, Embase, Cochrane, China Knowledge, Wanfang, and China Biomedical Literature Database, were searched for relevant studies from database establishment up to January 31, 2023. The Cochrane risk of bias tool was used to assess the quality of randomized controlled trials, qualitative studies, and single-armed trials on the basis of the literature evaluation criteria developed by the JBI Center for Evidence-Based Healthcare in Australia.

Tetramethylpyrazine Nitrone in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.

Importance: Tetramethylpyrazine nitrone has exhibited promising results in improving motor dysfunction in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS).

Objective: To evaluate the safety and efficacy of orally administered tetramethylpyrazine nitrone in patients with ALS.

Design, Setting, And Participants: This phase 2, multicenter, double-masked, placebo-controlled, randomized clinical trial was conducted from December 24, 2020, through July 14, 2023, in 11 centers in China, with a 180-day follow-up.

A Multicenter Study of Hereditary Transthyretin Amyloidosis in China.

Objective: Hereditary transthyretin amyloidosis (ATTRv) is an autosomal dominant genetic disease characterized by the misfolding and deposition of the transthyretin (TTR) protein. This study aimed to describe the clinical and genetic characteristics of ATTRv in a large multicenter Chinese cohort.

Methods: Patients from 14 centers were included in the study.

Biallelic variants in SREBF2 cause autosomal recessive spastic paraplegia.

Hereditary spastic paraplegias (HSPs) refer to a genetically and clinically heterogeneous group of neurodegenerative disorders characterized by the degeneration of motor neurons. To date, a significant number of patients still have not received a definite genetic diagnosis. Therefore, identifying unreported causative genes continues to be of great importance.

The Factors Influencing Early Ambulation in Patients With Gastrointestinal Neoplasms: A Mixed Study.

Background: Early ambulation helps improve postoperative recovery in gastrointestinal neoplasm patients. However, compliance with early ambulation remains low.

Objective: This study aimed to explore the influencing factors and experiences of early ambulation in gastrointestinal neoplasm patients and to provide suggestions for subsequent intervention programs.

CD2AP deficiency aggravates Alzheimer's disease phenotypes and pathology through p38 MAPK activation.

Background: Alzheimer's disease (AD) is the most common form of neurodegenerative disorder, which is characterized by a decline in cognitive abilities. Genome-wide association and clinicopathological studies have demonstrated that the CD2-associated protein (CD2AP) gene is one of the most important genetic risk factors for AD. However, the precise mechanisms by which CD2AP is linked to AD pathogenesis remain unclear.

Single-Nucleus RNA Sequencing Reveals the Spatiotemporal Dynamics of Disease-Associated Microglia in Amyotrophic Lateral Sclerosis.

Disease-associated microglia (DAM) are observed in neurodegenerative diseases, demyelinating disorders, and aging. However, the spatiotemporal dynamics and evolutionary trajectory of DAM during the progression of amyotrophic lateral sclerosis (ALS) remain unclear. Using a mouse model of ALS that expresses a human gene mutation, we found that the microglia subtype DAM begins to appear following motor neuron degeneration, primarily in the brain stem and spinal cord.

Eye Movement and Gait Variability Analysis in Chinese Patients With Huntington's Disease.

Objective: Huntington's disease (HD) is characterized by motor, cognitive, and neuropsychiatric symptoms. Oculomotor impairments and gait variability have been independently considered as potential markers in HD. However, an integrated analysis of eye movement and gait is lacking.

Effluent quality soft sensor for wastewater treatment plant with ensemble sparse learning-based online next generation reservoir computing.

Real-time monitoring of key quality variables is essential and crucial for stable and safe operations of wastewater treatment plants (WWTPs). Next generation reservoir computing (NG-RC) has recently garnered significant attention in quality prediction, such as COD and BOD, as an effective alternative to traditional reservoir computing (RC), then is able to act as a data-driven soft sensor to twin a hardware sensor for quality variable measurements. Unlike RC, NG-RC does not require random sampling matrices to define the weights of recurrent neural networks and has fewer hyperparameters.

Tetraphenylethylene-Derived Tetracarboxylate Featuring AIE Properties for Dual Ion Sensing and Mechanochromic Self-Erasable Writing.

The integration of multiple functions within a single fluorescent molecule provides a promising platform for developing versatile, efficient, and cost-effective materials with enhanced performance across diverse applications. In this study, we introduce TPEC, an aggregation-induced emission (AIE) molecule derived from tetraphenylethylene-based tetracarboxylate, which demonstrates multifunctional capabilities, including metal ion sensing and self-erasable writing. TPEC exhibits amphiphilicity in water, self-assembling into single-layer nanosheets with robust blue fluorescence.

YTHDF2 upregulation and subcellular localization dictate CD8 T cell polyfunctionality in anti-tumor immunity.

RNA methylation is an important regulatory process to determine immune cell function but how it affects the anti-tumor activity of CD8 T cells is not fully understood. Here we show that the N-methyladenosine (mA) RNA reader YTHDF2 is highly expressed in early effector or effector-like CD8 T cells. We find that YTHDF2 facilitates nascent RNA synthesis, and mA recognition is fundamental for this distinctively nuclear function of the protein, which also reinforces its autoregulation at the RNA level.

Clinical characterization and founder effect analysis in Chinese amyotrophic lateral sclerosis patients with common variants.

Objective: In the Asian population, variants are the most common cause of amyotrophic lateral sclerosis (ALS). To date, more than 200 variants have been reported in . This study aimed to summarize the genotype-phenotype correlation and determine whether the patients carrying common variants derive from a common ancestor.

Genotype-phenotype correlation and founder effect analysis in southeast Chinese patients with sialidosis type I.

Background: Sialidosis type 1 (ST-1) is a rare autosomal recessive disorder caused by mutation in the NEU1 gene. However, limited reports on ST-1 patients in the Chinese mainland are available.

Methods: This study reported the genetic and clinical characteristics of 10 ST-1 patients from southeastern China.

An intervention study on college students' employment anxiety based on interpretation bias modification: A randomized controlled experiment.

External environmental factors and internal cognitive bias affect college students' anxiety while job hunting. The current study is an intervention study on alleviating employment anxiety among college students through an Interpretation Bias Modification (IBM) computer-based intervention. A total of 79 valid participants were recruited.

Progressive Ataxia due to de novo Missense Variants in the CACNA1A Gene.

The CACNA1A gene encodes the alpha-1A subunit of P/Q type voltage-gated calcium channel Ca2.1, which is associated with a broad clinical spectrum and variable symptomatology. While few patients with progressive ataxia caused by CACNA1A missense variants have been reported, here we report three unrelated Chinese patients with progressive ataxia due to de novo missense variants in the CACNA1A gene, including a novel pathogenic variant (c.

Multi-omics Analysis Reveals Key Gut Microbiota and Metabolites Closely Associated with Huntington's Disease.

Dysbiosis of the gut microbiota is closely associated with neurodegenerative diseases, including Huntington's disease (HD). Gut microbiome-derived metabolites are key factors in host-microbiome interactions. This study aimed to investigate the crucial gut microbiome and metabolites in HD and their correlations.

Hybrid Membrane-Coated Nanoparticles for Precise Targeting and Synergistic Therapy in Alzheimer's Disease.

The blood brain barrier (BBB) limits the application of most therapeutic drugs for neurological diseases (NDs). Hybrid cell membrane-coated nanoparticles derived from different cell types can mimic the surface properties and functionalities of the source cells, further enhancing their targeting precision and therapeutic efficacy. Neuroinflammation has been increasingly recognized as a critical factor in the pathogenesis of various NDs, especially Alzheimer's disease (AD).

A sequential light-harvesting system with thermosensitive colorimetric emission in both aqueous solution and hydrogel.

Inspired by natural photosynthetic systems that feature both sequential energy transfer and temperature response, we herein report an artificial thermosensitive sequential light-harvesting system (LHS) based on an amphiphilic molecule TPEO. It self-assembles into fluorescent nanoparticles in water and shows tunable LCST behavior. By loading ESY as the first acceptor and NiR as the second acceptor into the nanoparticles, an artificial LHS with two-step FRET was successfully constructed.