Numerical simulations of elastic-plastic Richtmyer-Meshkov instability of multiple interfaces.

The elastic-plastic Richtmyer-Meshkov instability of multiple interfaces is investigated by numerical simulation using a multimaterial solid mechanics algorithm based on an Eulerian framework. This Richtmyer-Meshkov instability problem is realized by a copper layer that is flanked by vacuum and a copper block of different material strength. The research efforts are directed to reveal the influence of the layer thickness and material strength on the deformation of the perturbed solid-vacuum interface impacted by an initial shock.

Red Rice Seed Coat Targeting SPHK2 Ameliorated Alcoholic Liver Disease via Restored Intestinal Barrier and Improved Gut Microbiota in Mice.

Alcoholic liver disease (ALD), leading to the most common chronic liver diseases, is increasingly emerging as a global health problem, which is intensifying the need to develop novel treatments. Herein, our work aimed to estimate the therapeutic efficacy of red rice ( L.) seed coat on ALD and further uncover the underlying mechanisms.

L. Indica Seed Coat Ameliorated Concanavalin A-Induced Acute Hepatitis in Mice via MDM2/p53 and PKCα/MAPK1 Signaling Pathways.

Acute hepatitis (AH) is a common liver disease with an increasing number of patients each year, requiring the development of new treatments. Hence, our work aimed to evaluate the therapeutic effect of L. indica (purple rice) seed coat on concanavalin A (ConA)-induced AH and further reveal its potential mechanisms.

miR-30a-3p Regulates Autophagy in the Involution of Mice Mammary Glands.

The mammary gland undergoes intensive remodeling during the lactation cycle, and the involution process of mammary gland contains extensive epithelial cells involved in the process of autophagy. Our studies of mice mammary glands suggest that miR-30a-3p expression was low during involution compared with its high expression in the mammary glands of lactating mice. Then, we revealed that miR-30a-3p negatively regulated autophagy by autophagy related 12 () in mouse mammary gland epithelial cells (MMECs).

Elsholtzia bodinieri Vaniot ameliorated acute lung injury in mice by regulating pyroptosis, inflammation, oxidative stress and macrophage polarization.

Ethnopharmacological Relevance: Elsholtzia bodinieri Vaniot, perennial herbs, a traditional Yunnan Chinese herbal medicine. Its whole herb can be used as commonly used herbs to cure fever, headache, inflammation, indigestion etc., and its tender tip can also be used as tea in Yunnan of China.

Vaniot Ameliorated Acute Lung Injury by NQO1, BCL2 and PTGS2 In Silico and In Vitro Analyses.

Acute lung injury (ALI) is a clinical respiratory disease caused by various factors, which lacks effective pharmacotherapy to reduce the mortality rate. Vaniot is an annual herbaceous plant used as a traditional herbal tea and folk medicine. Here we used bioinformatic databases and software to explore and analyze the potential key genes in ALI regulated by Vaniot, including B cell leukemia/lymphoma 2 (), prostaglandin-endoperoxide synthase 2 () and NAD(P)H dehydrogenase, quinone 1 ().

Scaling law of mixing layer in cylindrical Rayleigh-Taylor turbulence.

The nonlinear evolution of mixing layer in cylindrical Rayleigh-Taylor (RT) turbulence is studied theoretically and numerically. The scaling laws including the hyperbolic cosine growth for outward mixing layer and the cosine growth for inward mixing layer of the cylindrical RT turbulence are proposed for the first time and verified reliably by direct numerical simulation of the Navier-Stokes equations. It is identified that the scaling laws for the cylindrical RT turbulence transcend the classical power law for the planar RT turbulence and can be recovered to the quadratic growth as cylindrical geometry effect vanishes.