Effects of Cold Deformation and Heat Treatments on the Microstructure and Properties of Fe-15Cr-25Ni Superalloy Cold-Drawn Bars.

The combination of cold deformation and solution aging is an important technological route for the bar processing of superalloy fasteners. The microstructure evolution and mechanical properties are intimately related to the process parameters. In this study, we systematically elucidate the mechanical properties and microstructure evolution of Fe-15Cr-25Ni alloys in different treatment processes and conduct in-depth analysis of the synergistic strengthening mechanism of fine-crystal strengthening, second-phase strengthening, and work hardening on Fe-15Cr-25Ni alloys.

MicroRNAs: A novel signature in the metastasis of esophageal squamous cell carcinoma.

Esophageal squamous cell carcinoma (ESCC) is a malignant epithelial tumor, characterized by squamous cell differentiation, it is the sixth leading cause of cancer-related deaths globally. The increased mortality rate of ESCC patients is predominantly due to the advanced stage of the disease when discovered, coupled with higher risk of metastasis, which is an exceedingly malignant characteristic of cancer, frequently leading to a high mortality rate. Unfortunately, there is currently no specific and effective marker to predict and treat metastasis in ESCC.

circRNADisease v2.0: an updated resource for high-quality experimentally supported circRNA-disease associations.

circRNADisease v2.0 is an enhanced and reliable database that offers experimentally verified relationships between circular RNAs (circRNAs) and various diseases. It is accessible at http://cgga.

Investigation of water quality and aquatic ecological succession of a newly constructed river replenished by reclaimed water in Beijing.

The potential to create new ecosystems in rivers is possible through the use of reclaimed water as a replenishment source, although the long-term effects of this method are unknown. In this study, the water quality and aquatic ecological evolution of a newly constructed river replenished by reclaimed water in Beijing (the Jing River) were investigated, and the conventional water quality, phytoplankton indicators, and submerged plant growth conditions from October 2018 to December 2020 were analyzed. Spearman's correlation and redundancy analysis between possible influential environmental factors and algal indicators were conducted.

Prediction of IDH mutation status of glioma based on terahertz spectral data.

Gliomas are the most common type of primary tumor in the central nervous system in adults. Isocitrate dehydrogenase (IDH) mutation status is an important molecular biomarker for adult diffuse gliomas. In this study, we were aiming to predict IDH mutation status based on terahertz time-domain spectroscopy technology.

Effectiveness of online expressive writing in reducing psychological distress among the asymptomatic COVID-19 patients in Fangcang Hospitals: A quasi-experiment study.

Objective: This study aimed to assess the applicability and effectiveness of an online format of expressive writing (EW) in reducing psychological distress among the asymptomatic COVID-19 patients in Fangcang Hospitals with a quasi-experiment.

Method: Altogether 244 patients were assigned to the EW group(n=122) and the control group(n=122). Besides the routine psychological intervention (broadcast relaxation training at a fixed time) in Fangcang hospitals, The EW group was engaged in 8-day theme-based adaption EW intervention, whereas the control group received no interventions.

Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma.

Detailed characterizations of genomic alterations have not identified subtype-specific vulnerabilities in adult gliomas. Mapping gliomas into developmental programs may uncover new vulnerabilities that are not strictly related to genomic alterations. After identifying conserved gene modules co-expressed with EGFR or PDGFRA (EM or PM), we recently proposed an EM/PM classification scheme for adult gliomas in a histological subtype- and grade-independent manner.

Substances released during the decomposition of and .

Two types of aquatic plants commonly used for the ecological restoration of rivers and lakes, (Lour.) Hara and Fraser ex Roscoe, were selected and grouped by plant parts (root, stem and foliage), and decomposing release experiments were conducted. The influence of the released substances on the water quality was analyzed, as well as the amount of nutrients released by each part of these two plants.

WES data from 286 diffuse gliomas under the 2021 WHO Classification of Tumors of the Central Nervous System.

Diffuse gliomas (DGs) are the most common and lethal primary neoplasms in the central nervous system. The latest 2021 World Health Organization (WHO) Classification of Tumors of the Central Nervous System (CNS) was published in 2021, immensely changing the approach to diagnosis and decision making. As a part of the Chinese Glioma Genome Atlas (CGGA) project, our aim was to provide genomic profiling of gliomas in a Chinese cohort.

Identification of tumor-associated antigens and immune subtypes of lower-grade glioma and glioblastoma for mRNA vaccine development.

Background: mRNA became a promising therapeutic approach in many diseases. This study aimed to identify the tumor antigens specifically expressed in tumor cells for lower-grade glioma (LGG) and glioblastoma (GBM) patients.

Methods: In this work, the mRNA microarray expression profile and clinical data were obtained from 301 samples in the Chinese Glioma Genome Atlas (CGGA) database, the mRNA sequencing data and clinical data of 701 samples were downloaded from The Cancer Genome Atlas (TCGA) database.

A novel chemokine-based signature for prediction of prognosis and therapeutic response in glioma.

Aims: Gliomas are the primary malignant brain tumor and characterized as the striking cellular heterogeneity and intricate tumor microenvironment (TME), where chemokines regulate immune cell trafficking by shaping local networks. This study aimed to construct a chemokine-based gene signature to evaluate the prognosis and therapeutic response in glioma.

Methods: In this study, 1024 patients (699 from TCGA and 325 from CGGA database) with clinicopathological information and mRNA sequencing data were enrolled.

Perineural Invasion Is a Significant Indicator of High Malignant Degree and Poor Prognosis in Esophageal Cancer: A Systematic Review and Meta-Analysis.

Background: Perineural invasion (PNI) is a malignant metastatic mode of tumors and has been reported in many tumors including esophageal cancer (EC). However, the role of PNI in EC has been reported differently. This systematic review and meta-analysis aims to focus on the role of PNI in EC.

Image-Based Differentiation of Intracranial Metastasis From Glioblastoma Using Automated Machine Learning.

Purpose: The majority of solitary brain metastases appear similar to glioblastomas (GBMs) on magnetic resonance imaging (MRI). This study aimed to develop and validate an MRI-based model to differentiate intracranial metastases from GBMs using automated machine learning.

Materials And Methods: Radiomics features from 354 patients with brain metastases and 354 with GBMs were used to build prediction algorithms based on T2-weighted images, contrast-enhanced (CE) T1-weighted images, or both.

A Novel TNFSF-Based Signature Predicts the Prognosis and Immunosuppressive Status of Lower-Grade Glioma.

Purpose: Tumour necrosis factor (TNF) superfamilies play important roles in cell proliferation, migration, differentiation, and apoptosis. We believe that TNF has a huge potential and might cast new insight into antitumour therapies. Therefore, we established this signature based on TNF superfamilies.

Corner-opening and corner-capping of mono-substituted T POSS: product distribution and isomerization.

We applied chromatographic and spectroscopic techniques to revisit the product distribution of the corner-opening and corner-capping reactions of monosubstituted T POSS. The monosubstituted Si is more likely to be removed than the remaining seven Si atoms during the corner-opening. After the corner-capping, the yield of monosubstituted T POSS is much higher than the yields of the - and -isomers of disubstituted T POSS, and the -isomer is negligible.

Molecular Characterization and Clinical Relevance of in Gliomas 1,018 Chinese Cohort Patients.

Annexin A1 (ANXA1) is a calcium-dependent phospholipid-binding protein and has been implicated in multiple functions essential in cancer, including cell proliferation, apoptosis, chemosensitivity, metastasis, and invasion. However, the biological role and clinical behavior of in glioma remain unclear. In this study, RNA-seq ( = 1018 cases) and whole-exome sequencing (WES) ( = 286 cases) data on a Chinese cohort, RNA-seq data with different histological regions of glioblastoma blocks ( = 270 cases), and scRNA-seq data ( = 7630 cells) were used.

Preoperative Radiomics Analysis of 1p/19q Status in WHO Grade II Gliomas.

Purpose: The present study aimed to preoperatively predict the status of 1p/19q based on radiomics analysis in patients with World Health Organization (WHO) grade II gliomas.

Methods: This retrospective study enrolled 157 patients with WHO grade II gliomas (76 patients with astrocytomas with mutant IDH, 16 patients with astrocytomas with wild-type IDH, and 65 patients with oligodendrogliomas with mutant IDH and 1p/19q codeletion). Radiomic features were extracted from magnetic resonance images, including T1-weighted, T2-weighted, and contrast T1-weighted images.

Radiomics Features Predict Promoter Mutations in World Health Organization Grade II Gliomas a Machine-Learning Approach.

The detection of mutations in telomerase reverse transcriptase promoter (p) is important since preoperative diagnosis of p status helps with evaluating prognosis and determining the surgical strategy. Here, we aimed to establish a radiomics-based machine-learning algorithm and evaluated its performance with regard to the prediction of mutations in p in patients with World Health Organization (WHO) grade II gliomas. In total, 164 patients with WHO grade II gliomas were enrolled in this retrospective study.

Radiogenomic analysis of vascular endothelial growth factor in patients with diffuse gliomas.

Objective: To predict vascular endothelial growth factor (VEGF) expression in patients with diffuse gliomas using radiomic analysis.

Materials And Methods: Preoperative magnetic resonance images were retrospectively obtained from 239 patients with diffuse gliomas (World Health Organization grades II-IV). The patients were randomly assigned to a training group (n = 160) or a validation group (n = 79) at a 2:1 ratio.

Genome-Wide CRISPR-Cas9 Screening Identifies NF-κB/E2F6 Responsible for EGFRvIII-Associated Temozolomide Resistance in Glioblastoma.

Amplification of epidermal growth factor receptor (EGFR) and active mutant EGFRvIII occurs frequently in glioblastoma (GBM) and contributes to chemo/radio-resistance in various cancers, especially in GBM. Elucidating the underlying molecular mechanism of temozolomide (TMZ) resistance in GBM could benefit cancer patients. A genome-wide screening under a clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 library is conducted to identify the genes that confer resistance to TMZ in EGFRvIII-expressing GBM cells.

Radiogenomic analysis of PTEN mutation in glioblastoma using preoperative multi-parametric magnetic resonance imaging.

Purpose: PTEN mutation status is a pivotal biomarker for glioblastoma. This study aimed to establish a radiomic signature to predict PTEN mutation status in patients with glioblastoma, and to investigate the genetic background behind this radiomic signature.

Methods: In this study, a total of 862 radiomic features were extracted from each patient.

Effect of Ultrasonic Surface Rolling Process on the Hot Compression Behavior of Inconel 718 Superalloy at 700 °C.

A series of hot compression tests at the temperature of 700 °C were applied to study the effect of the ultrasonic surface rolling process (USRP) on the hot compression behavior of Inconel 718 superalloy. The results indicated that the USRP-treated samples exhibited a better ability to withstand axial hot compression than the untreated samples. After the hot compression process, the size of the matrix grains was slightly decreased, and the volume fraction of ultra-fine recrystallized grains in the near-surface regions was increased for the USRP-treated samples.

mutation-specific radiomic signature in lower-grade gliomas.

Unravelling the heterogeneity is the central challenge for glioma precession oncology. In this study, we extracted quantitative image features from T2-weighted MR images and revealed that the () wild type and mutant lower grade gliomas (LGGs) differed in their expression of 146 radiomic descriptors. The logistic regression model algorithm further reduced these to 86 features.

A radiomic signature as a non-invasive predictor of progression-free survival in patients with lower-grade gliomas.

Objective: The aim of this study was to develop a radiomics signature for prediction of progression-free survival (PFS) in lower-grade gliomas and to investigate the genetic background behind the radiomics signature.

Methods: In this retrospective study, training (n = 216) and validation (n = 84) cohorts were collected from the Chinese Glioma Genome Atlas and the Cancer Genome Atlas, respectively. For each patient, a total of 431 radiomics features were extracted from preoperative T2-weighted magnetic resonance images.