Dual-view jointly learning improves personalized drug synergy prediction.

Motivation: Accurate and robust estimation of the synergistic drug combination is important for medicine precision. Although some computational methods have been developed, some predictions are still unreliable especially for the cross-dataset predictions, due to the complex mechanism of drug combinations and heterogeneity of cancer samples.

Results: We have proposed JointSyn that utilizes dual-view jointly learning to predict sample-specific effects of drug combination from drug and cell features.

Genome-wide characterization and identification of Trihelix transcription factors and expression profiling in response to abiotic stresses in Chinese Willow ( Koidz).

Trihelix transcription factors (TTF) are a class of light-responsive proteins with a typical triple-helix structure (helix-loop-helix-loop-helix). Members of this gene family play an important role in plant growth and development, especially in various abiotic stress responses. Koidz is an allotetraploid ornamental forest tree that is widely planted for its excellent resistance to stress, but no studies on its Trihelix gene family have been reported.

Stability and Chemical Conversion of the Purified Reference Material of Gymnodimine-A under Different Temperature and pH Conditions.

Gymnodimines (GYMs) are a group of fast-acting phycotoxins and their toxicological effects on human beings are still unclear due to the lack of sufficiently well-characterized large quantities of purified toxins for toxicology studies. In this study, a certified reference material (CRM) of GYM-A was prepared from the dinoflagellate , followed by multi-step chromatography separation and purification. Subsequently, the stability of GYM-A in methanolic media was evaluated at different temperature (-20, 4, and 20 °C) and pH (3, 5, and 7) conditions for 8 months, and the conversion products of GYM-A were explored by liquid chromatography-high resolution mass spectrometry (LC-HRMS).

Comparative study on the esterification of gymnodimine in different shellfish exposed to the dissolved toxin in seawater.

Some lipophilic phycotoxins dissolved in seawater can be accumulated by bivalves via the filtering process. To explore the relationship between the bioaccumulation of gymnodimine-A (GYM-A) and free fatty acids (FFAs) of shellfish, three species of bivalves (venus clam Meretrix meretrix, mussel Mytilus galloprovincialis, and ark shell Anadara kagoshimensis) were exposed to dissolved GYM-A for 7 days in the same seawater system. Results indicated that GYM-A can be accumulated by these bivalves from the dissolved phase and esterified with FFAs reaching over 90% in most tissues of bivalves.

Development of an Efficient Extraction Method for Harvesting Gymnodimine-A from Large-Scale Cultures of .

Gymnodimine-A (GYM-A) is a fast-acting microalgal toxin and its production of certified materials requires an efficient harvesting technology from the large-scale cultures of toxigenic microalgae. In this study the recoveries of GYM-A were compared between several liquid-liquid extraction (LLE) treatments including solvents, ratios and stirring times to optimize the LLE technique for harvesting GYM-A from cultures, of which the dichloromethane was selected as the extractant and added to microalgal cultures at the ratio 55 mL L (5.5%, /).

Effects of Polystyrene Microplastics on Growth and Toxin Production of .

Microplastics (MP) widely distributed in aquatic environments have adverse effects on aquatic organisms. Currently, the impact of MP on toxigenic red tide microalgae is poorly understood. In this study, the strain of ATHK, typically producing paralytic shellfish toxins (PST), was selected as the target.