Publications by authors named "Zhixiu Zhang"
Article Synopsis
- The study investigates the potential of Forsythoside B (FB), an anti-inflammatory compound, in protecting against cerebral ischemia/reperfusion injury (CIRI) in rats.
- Rats were subjected to a transient blockage of the middle cerebral artery, and FB was administered before the injury to assess its effects on brain damage and inflammatory responses.
- Results showed that FB reduced brain injury, decreased inflammation, and activated Sirt1 while inhibiting the harmful NLRP3 pathway, indicating its promise as a neuroprotective treatment.
Background: Ischemic stroke (IS) ranks as the second common cause of death worldwide. However, a narrow thrombolysis timeframe and ischemia-reperfusion (I/R) injury limits patient recovery. Moreover, anticoagulation and antithrombotic drugs do not meet the clinical requirements.
View Article and Find Full Text PDFAim Of The Study: Naoxinqing (NXQ) tablets are derived from persimmon leaves and are widely used in China for promoting blood circulation and removing blood stasis in China. We aimed to explore whether NXQ has the therapeutic effect on ischemic stroke and explored its possible mechanism.
Materials And Methods: The cerebral artery occlusion/reperfusion (MCAO/R) surgery was used to establish the cerebral ischemic/reperfusion rat model.
The gut-brain axis has been shown to play a vital role in the prognosis and recovery of ischemic stroke (IS), which is associated with gut microbiota dysfunction and changes in the gastrointestinal system and epithelial barrier integrity. In turn, gut microbiota and its derived metabolites can influence stroke outcomes. In this review, we first describe the relationship between IS (clinical and experimental IS) and the gut microbiota.
View Article and Find Full Text PDFAn entrepreneurial orientation is a method of implementing a strategy that makes use of a variety of resources that are owned by organizations. Entrepreneurial orientation is one of the primary factors that led to the company's founding. Risk sharing is a useful tactic that can be implemented by businesses in order to mitigate the amount of risk to which they are exposed.
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