Acteoside protects podocyte against apoptosis through regulating AKT/GSK-3β signaling pathway in db/db mice.

Background: Podocyte apoptosis is one of the important pathological mechanisms of diabetic kidney disease (DKD). Acteoside (Act), a major active component of Rehmannia glutinosa leaves total glycoside, has a strong renoprotective action. Our study aims to demonstrate Act's renoprotective actions in db/db mice.

Primordial odontogenic tumour: a case report.

Odontogenic primary tumor is a rare benign odontogenic tumor in the maxillofacial area. A case of odontogenic primary basal tumor is reported. The clinicopathological features and treatment principles are discussed in the literature.

Effect of high-quality nursing on postpartum hemorrhage and quality of life in puerperants with gestational hypertension.

Objective: To observe the effect of high-quality nursing on puerperants with gestational hypertension.

Methods: In this study, 144 puerperants with gestational hypertension admitted to our hospital were included and divided into a research group and a control group according to the nursing method. The control group (n = 72) adopted the routine nursing and the observation group (n = 72) adopted the high-quality nursing.

Solid variant of keratocystic odontogenic tumor with ameloblastomatous transformation: a case report and review of the literature.

The solid variant of keratocystic odontogenic tumor is an extremely rare tumor. Its clinical and pathologic features remain poorly defined, even in the 2005 World Health Organization odontogenic tumor classification. We report an unusual lesion in a 38-year-old female Chinese patient.

Primary central carcinoma ex pleomorphic adenoma of the mandible: report of a rare case and literature review.

We report a rare case of primary carcinoma ex pleomorphic adenoma (CXPA) of the mandible. A 13-year-old girl presented with a large mass, measuring about 30 cm in its greatest dimension, involving the mandible. She was referred to our department for surgery, and her postoperative course was uneventful; she is currently free from the disease 48 months after surgery.

[Tumors of different histological type in unilateral salivary glands: a case report].

Tumors of synchronous benign and malignant in unilateral salivary glands have rarely been reported. A case of 21-year-old girl who was diagnosed as synchronously adenoid cystic carcinoma of the left parotid and pleomorphic adenoma of the left submandibular gland. The classification, clinic pathology, diagnosis, possible mechanism were discussed based on similar literatures.

Malignant transformation of oral lichen planus: a retrospective study of 23 cases.

Objective: Oral lichen planus (OLP) is a common mucocutaneous disease with malignant transformation potential. The aim of this retrospective study was to investigate the characteristics of patients with OLP who developed oral squamous cell carcinoma (OSCC).

Method And Materials: The medical records of 2,119 patients with OLP at West China College of Stomatology, China, from 1951 to 2006, were reviewed.

Lymphoepithelial cyst of the parotid gland: its possible histopathogenesis based on clinicopathologic analysis of 64 cases.

Sixty-four cases of lymphoepithelial cysts of the parotid gland, the largest scale collection in the literature, were clinicopathologically analyzed for their possible pathogenesis. All 64 cases were unilateral, 27 left and 37 right. There were 28 male and 36 female patients with a ratio of 1:1.

Epithelial salivary gland tumors of children and adolescents in west China population: a clinicopathologic study of 79 cases.

Objective: Determine the clinical and histopathologic features of epithelial salivary gland tumors of children and adolescents.

Methods: A total of 79 cases of epithelial salivary gland tumors of children and adolescents were retrieved from the files. Information about demographic, clinical, histopathologic characteristics, and follow-up status were analyzed.

[Effect of focal adhesion kinase on biological characteristics of Tca8113 tongue squamous cell carcinoma].

Objective: To investigate the effect of FAK on biological characteristics of tongue squamous cell carcinoma cell Tca8113.

Methods: Lipofect was used to transfect FAK into Tca8113 cell lines. The difference in expression of FAK between the transfected and non-transfected cell lines was detected by immunofluorescence assay.

[Function of P63 on the development of salivary glands].

Objective: To study the expression of P63 in human salivary gland development and the existing of salivary gland stem cells.

Methods: 24 embryonic salivary gland samples in different stage, 10 normal salivary gland samples were collected. HE-stained and immunochemistry stain were used.

Intraoral minor salivary gland tumors in a Chinese population: a retrospective study on 737 cases.

Objectives: This study aimed to investigate the diverse histopathological types and distribution characteristics of epithelial minor salivary gland tumors (MSGTs) in a Chinese population.

Study Design: We conducted a descriptive demographic study of 737 intraoral MSGTs in patients in southwest China from 1990 to 2004.

Results: A total of 737 epithelial MSGTs, consisting of 340 (46.

[Expression and clinical significance of focal adhesion kinase in oral squamous cell carcinoma].

Objective: To study the correlation between expression levels of focal adhesion kinase (FAK) in oral squamous cell carcinoma (OSCC) and clinical prognosis with pathologic parameters.

Methods: Eighty paraffin embedded tissue specimens of OSCC were studied by immunohistochemistry. The data was analyzed by SPSS statistical software.

[Expression of deltaNp63 in salivary gland tumours].

Objective: To detect the expression of deltaNp63 in human salivary gland tumor and analyze its role in the malignant salivary gland tumors.

Methods: Collecting the samples from 68 cases of pathologically proven salivary gland tumours and investigating the microscopic sections with HE stain and immunohistochemical-SP stain.

Results: It was found that the expression of deltaNp63 is gradually increased in the malignant tumours, the myoepithelial cells and the basal cells of the salivary gland tumors are positive, and the expression of deltaNp63 is correlated directly with benign and malignant tumor.

[Clinicopathological study of Ewing's sarcoma/primitive neuroectodermal tumor in oral and maxillofacial region].

Objective: To study the clinicopathological features and diagnostic criteria of Ewing's sarcoma/primitive neuroectodermal tumor (Ewing's sarcoma/PNET) in oral and maxillofacial region.

Methods: There were 15 patients with Ewing's sarcoma/PNET in the last 35 years at our hospital, aged 1-49 years and mean 14.5 years.

[A retrospective study on 615 cases of minor salivary gland tumors].

Objective: To analyse the clinical and pathological characteristics of minor salivary gland tumors.

Methods: A retrospective analysis on 615 cases of intraoral minor salivary gland tumors from 1990-2002 with a confirmed pathologic diagnosis was carried out.

Results: In 615 cases of minor salivary gland tumors, 265 cases were benign, 350 cases malignant.

[The correlation between neck lymphy node metastasis and matrixmetalloproteinase-2 expression at the invasive tumor front of oral squamous cell carcinomas].

Objective: To explore the correlation between neck lymph node metastasis and matrix metalloproteinase-2 expression at the invasive tumor front of oral squamous cell carcinomas(OSCC).

Methods: Immunohistochemistry LsAB technique was used to observe the expression of MMP-2 at the invasive tumor front and center of OSCC, and the correlation between the expression of MMP-2 in OSCC and neck lymph node metastasis were respectively analyzed by statistics.

Results: The results demonstrated that MMP-2 existed in all 71 cases, which the expression of MMP-2 at the OSCC front was more significant than that of MMP-2 at the OSCC center (P < 0.

[Infection of human papillomavirus in oral benign epithelial proliferation in children].

Objective: To investigate the presence of HPV infection of oral mucosa proliferative lesions in children and determine the associations of HPV types with oral mucosa lesions in children.

Methods: Immunohistochemical method and in situ hybridization techniques were applied to detect human papillomavirus (HPV) infection in biopsies taken from clinical lesions in oral mucosa of 30 children.

Results: The most frequent lesions detected were SCP (66.

[The age-related changes of P53 protein expression in oral mucosa and their effects on oral leukoplakia].

Objective: To investigate the age-related changes of P53 protein expression in oral mucous membrane and their effects on pathogenesis of the oral precancerous lesions in elderly people.

Methods: An immunohistochemical technique (SP method) was applied to study the changes of P53 expression in normal oral mucosa and oral leukoplakia(OLK) in different age groups. The staining results were evaluated by semi-quantity method.

[A clinical and pathological study on primary oral mucosal malignant melanoma].

Objective: The aim of this study was to investigate the association between clinical and pathological characteristics of primary oral mucosal malignant melanoma and the prognosis of this disease.

Methods: Clinical and pathological characters of 73 cases primary oral mucosal malignant melanoma were investigated. The association between risk factors, such as black macule, lymph node metastases, invasive depth, clinic stages, pathologic types, and prognosis was analyzed using Kaplan-Meier survival analysis and Log rank test.

[Flowcytometry DNA analysis of oral and maxillofacial non-Hodgkin's lymphoma].

Objective: The purpose of this study was to investigate the relationship between the results of flowcytometry analyses of different clinical stage, location, pathologic grade and cell origin of oral and maxillofacial non-Hodgkin's lymphoma (NHL), and the diagnostic value of flowcytometry analysis in lymphoma.

Method: This study analyzed 50 oral and maxillofacial NHL cases and 10 reactive lymph nodes (formalin fixed and paraffin embedded) by flowcytometry (FCM).

Results: Reactive lymph nodes were all diploid.

[A retrospective study of clinical manifestation and human papilloma virus detection of oral condyloma acuminate in children].

Objective: The aim of this study is to study genotype, transmission, clinical and pathological characteristics, and prognosis of oral condyloma acuminate (CA) in children.

Methods: The authors retrospected the clinical characteristics and slices of HE staining of six cases which have been diagnosed as oral CA and, performed inmunohistochemistry (IHC) and in situ hybridization (ISH) analysis to detect the DNA of human papilloma virus in 5 cases.

Results: Oral CA often happened in the hard or soft plates of children of two-year-old.

[Comparative study on effects of sodium hyaluronate and prednisolone injections on experimental temporomandibular joint osteoarthritis of rabbits].

Objective: To assess the treatment effect of sodium hyaluronate (HA) on experimental temporomandibular joint (TMJ) osteoarthritis of rabbits in comparison with prednisolone (PS).

Methods: The upper compartments of both TMJs of 12 Japanese White Ear Rabbits were injected with 0.2 ml of 1.