Publications by authors named "Zhixiong Liao"

Article Synopsis
  • Giant Cell Arteritis (GCA) is an autoimmune disease that researchers are studying to understand how gut microbiota may influence its development and progression.
  • The study used advanced statistical methods to analyze the relationship between various gut microbial taxa and GCA, revealing significant associations with nine specific taxa.
  • Key findings indicated that certain gut microbiota can affect GCA risk through interactions with immune mediators, suggesting potential new approaches for treating the disease.
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The development of wearable electronics has led to the growing demand for the self-powered and maintenance-free power sources. Under these circumstances, thermoelectric generators are considered promising candidates, which can directly convert body heat into electricity to power wearable electronics. However, most of the thermoelectric materials are either brittle or unrecoverable under external physical damage.

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To analyze the pathogenic bacteria, feature of drug resistance and the efficacy of dexamethasone as the auxiliary medication in pediatric refractory purulent meningitis (PM). The 190 refractory PM child patients were selected for the culture of pathogenic bacteria and analysis of drug resistance. In total, 190 pathogenic bacteria were detected, consisting of gram-positive bacteria (77.

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Quinoline synthesis from easily accessible raw materials such as anilines is a valuable and meaningful task. Herein, we communicate an iodide- and silver-mediated C-H/C-H oxidative annulation-aromatization between anilines and allyl alcohols. This protocol provides a direct route to the synthesis of quinoline derivatives from inexpensive commodities.

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Article Synopsis
  • The Cu(I)/Cu(II) and Cu(I)/Cu(III) catalytic cycles are crucial in copper-catalyzed oxidative coupling reactions, sparking significant debate in the field.
  • A study using X-ray absorption and electron paramagnetic resonance spectroscopies has clarified how Cu(II) is reduced to Cu(I) by 1,3-diketones, emphasizing the importance of halide ions in this reduction process.
  • The findings provide valuable mechanistic insights into using copper for oxidative cyclization, offering a straightforward method to synthesize highly substituted dihydrofurans from readily available 1,3-dicarbonyls and olefins.
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A simple copper-catalyzed direct radical carbooxygenation of styrenes is developed utilizing alkyl bromides as radical resources. This catalytic radical difunctionalization accomplishes both alkylation and alkoxylation of styrenes in one pot. A broad range of styrenes and alcohols are well tolerated in this transformation.

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A copper-catalysed direct radical alkenylation of various benzyl bromides and α-carbonyl alkyl bromides has been developed. Compared with the recent radical alkenylations which mostly focused on secondary or tertiary alkyl halides, this transformation shows good reactivity to primary alkyl halides and tertiary, secondary alkyl halides were also tolerated. The key initiation step of this transformation is a copper-induced single-electron reduction of C-Br bonds to generate alkyl radical species.

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Objective: To isolate exosomes from rabbit aqueous humor and to investigate their immunosuppression function.

Methods: Aqueous humor was collected from 40 New Zealand rabbits and exosomes were isolated by fractional separation and ultracentrifugation methods; the morphology was studied with electron microscopy. The immunosuppressive-related proteins of exosomes were detected with Western blotting; their inhibitory effect on ConA-induced proliferation of T lymphocyte was estimation with CCK-8 cells proliferation assay.

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This study was designed to examine the anticancer, antioxidant and antimicrobial activities of the essential oil from Lycopus lucidus Turcz. var. hirtus Regel.

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Objective: To prepare monoclonal antibodies (McAbs) against human mesenchymal stem cells (hMSCs) and to study their biological characteristics.

Methods: BALB/C mice were immunized with pooled hMSCs. McAbs were prepared by hybridoma technique and their biological characteristics were analyzed by indirect immunofluorescence, immunohistochemistry and flow cytometry.

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Objective: To construct the eukaryotic expression plasmid containing mouse vasoactive intestinal peptide(VIP) gene with biological activities.

Methods: VIP cDNA including the sequences of signal peptide was cloned from mouse thymus by RT-PCR, and then inserted into the mammalian expression vector pcDNA3.1 between Hind III and EcoR I restriction sites.

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