Nutritional Programming of the Lifespan of Male Drosophila by Activating FOXO on Larval Low-Nutrient Diet.

Nutrition during the developmental stages has long-term effects on adult physiology, disease and lifespan, and is termed nutritional programming. However, the underlying molecular mechanisms of nutritional programming are not yet well understood. In this study, we showed that developmental diets could regulate the lifespan of adult in a way that interacts with various adult diets during development and adulthood.

Iron Metabolism in Aging and Age-Related Diseases.

Iron is a trace metal element necessary to maintain life and is also involved in a variety of biological processes. Aging refers to the natural life process in which the physiological functions of the various systems, organs, and tissues decline, affected by genetic and environmental factors. Therefore, it is imperative to investigate the relationship between iron metabolism and aging-related diseases, including neurodegenerative diseases.

VhaAC39-1 regulates gut homeostasis and affects the health span in Drosophila.

Gut homeostasis is a dynamically balanced state to maintain intestinal health. Vacuolar ATPases (V-ATPases) are multi-subunit proton pumps that were driven by ATP hydrolysis. Several subunits of V-ATPases may be involved in the maintenance of intestinal pH and gut homeostasis in Drosophila.

SIRT6 serves as a polyhedron in glycolytic metabolism and ageing-related diseases.

Sirtuin 6 (SIRT6) is a nicotinamide adenine dinucleotide (NAD)-dependent enzyme. It is a novel member of the sirtuin family that has been shown to have an important role in various molecular pathways in glycolysis, cancer, and neurodegenerative responses. Recently, SIRT6 has emerged as a prominent research issue because its biochemical activity and regulation are possibly associated with human metabolism and disease.