Publications by authors named "Zhiwei Zhan"

Article Synopsis
  • The study aims to analyze how the bone mass and volume in the low-density area under the tibial plateau affects the force line of the lower limb, which is important for managing knee osteoarthritis (KOA) and preventing internal displacement during knee varus.
  • Researchers used imaging data to create models of the knee joint and varying low-density regions to simulate different bone mass conditions and study their effects on stress and displacement under physical loads.
  • The findings indicated that the KOA model accurately reflects normal limb anatomy, showing specific stress and displacement patterns that can inform clinical approaches to treating lower limb issues in KOA patients.
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Objective: To establish finite element models of different preserved angles of osteonecrosis of the femoral head (ONFH) for the biomechanical analysis, and to provide mechanical evidence for predicting the risk of ONFH collapse with anterior preserved angle (APA) and lateral preserved angle (LPA).

Methods: A healthy adult was selected as the study object, and the CT data of the left femoral head was acquired and imported into Mimics 21.0 software to reconstruct a complete proximal femur model and construct 3 models of necrotic area with equal volume and different morphology, all models were imported into Solidworks 2022 software to construct 21 finite element models of ONFH with LPA of 45°, 50°, 55°, 60°, 65°, 70°, and 75° when APA was 45°, respectively, and 21 finite element models of ONFH with APA of 45°, 50°, 55°, 60°, 65°, 70°, 75° when LPA was 45°, respectively.

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Microplastic pollution has exhibited a global distribution, including seas, lakes, rivers, and terrestrial environment in recent years. However, little attention was paid on the atmospheric environment, though the fact that plastic debris can escape as wind-blown debris was previously reported. Thus, characteristics of microplastics in the atmospheric fallout from Dongguan city were preliminarily studied.

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While large quantities of studies on microplastics in the marine environment have been widely carried out, few were available in the freshwater environment. The occurrence and characteristics, including composition, abundance, surface texture and interaction with heavy metals, of microplastics in the surface sediments from Beijiang River littoral zone were investigated. The concentrations of microplastics ranged from 178 ± 69 to 544 ± 107 items/kg sediment.

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The concentrations of 16 organochlorine pesticides (OCPs) in 7 water samples collected from different sites of water source areas of Guangdong and Guangxi were detected by SPE-GC-MS, and then the pollution characteristics were analyzed. This study established species sensitivity distribution(SSD) curves with BurrⅢ distribution model. In the meantime, HC values were calculated by BurrliOZ software, which were used to evaluate the toxicity effects of OCPs towards aquatic organisms.

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Though plastics show good chemical inertness, they could sorb polychlorinated biphenyls (PCBs) and other toxic pollutants from the surrounding environment. Thus, ingestion of microplastics by marine organisms potentially enhances the transport and bioavailability of toxic chemicals. However, there is lack of studies on the sorption capacity, mechanism and factors affecting the sorption behavior.

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Cinnamon ( ròu guì) has insulin potentiating activity, and proanthocyanidins from cinnamon prevent formation of advanced glycation end products. Some human studies were equivocal, but several have shown beneficial effects of cinnamon supplementation on circulating glucose, lipids, and/or insulin. This placebo-controlled double-blind trial tested the effects of a dried water extract of cinnamon () on circulating glucose, lipids, insulin, and insulin resistance.

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Objective: To master the epidemic situation and control effect of schistosomiasis in Yugan County, Jiangxi Province.

Methods: The data of the schistosomiasis prevalence in human and cattle as well as Oncomelania hupensis snail status were collected and the change trends were analyzed in Yugan County from 2008 to 2012.

Results: The schistosome infection rates of residents in Yugan County have declined every year since 2008, and currently, the prevalence of schistosomiasis was at a low level.

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Objective: To investigate the effects of teriparatide (hPTH1-34, PTH) and alendronate (Alen) on bone turnover rate and bone mineral density (BMD) of ovariectomized (OVX) osteoporotic rats.

Methods: 70 female 6-month-old Wistar rats were randomly divided into 7 groups: (1) baseline group: killed immediately as baseline controls; (2) sham operation group: injected subcutaneously with normal saline (NS) as normal controls; (3) OVXb group: underwent ovarietomy (OVX) and killed 6 weeks after OVX as pre-therapeutic controls; (4) OVXe group: injected with NS subcutaneously and then sacrificed 14 weeks after OVX as controls by the end of treatment; (5) PTH group: PTH 40 microg.kg(-1).

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Objectives: To evaluate relationship between serum level of leptin and the components of risk factors for metabolic syndrome and to analyze the characteristics and laws of clustering of the risk factors.

Methods: Totally, 795 non-diabetic adult Chinese subjects (691 men and 104 women, aged 40 - 75 years) from a diabetes prevalence survey in 2000 were involved in this study. Measurements included serum levels of true insulin (TI), leptin, fasting lipids, fasting glucose (FBG) and 2 h postchallenge glucose, as well as seated blood pressure (BP), body mass index (BMI), ratio of waist circumference to hip circumference (WHR), calculated quantitative insulin sensitivity check index (QUICKI), etc.

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Objective: To evaluate the precision of rat bone mineral density (BMD) measurements by Norland Excellplus dual-energy X-ray absorptiometry (DXA) and to investigate the BMD changes in ovariectomized (Ovx) rats in vitro.

Methods: (1) The coefficients of variation (CV) for BMD measurements at various skeletal regions were repeatedly determined by DXA in 10 Wistar rats in vitro. (2) BMD in lumbar vertebra (L5) and both sides of femurs was measured in total 90 rats.

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Objective: To assess the role of leptin in the pathogenesis of obesity-related hypertension and the relationship between blood pressure (BP), and body mass index (BMI), insulin resistance and leptin were examined.

Methods: 560 non-diabetic men, aged 35 - 75, selected from volunteers of health screening test during 2 000 were divided into hypertension group (n = 321, BP >or= 140/90 mm Hg without antihypertensive medication). and normal blood pressure group (n = 239).

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Objective: Leptin is involved in the regulation of body weight and metabolism. Previous data have suggested that leptin levels are related to insulin resistance and in a few reports with impaired insulin secretion. Some even revealed the existence of adipoinsular axis.

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