Publications by authors named "Zhiwei You"

In this study, a controllable mass‒frequency tuning method is presented using the etching of rib structures on a single-crystal PZT membrane. The rib structures were optimized to reduce the membrane mass while maintaining the stiffness; therefore, the center frequency could be increased to improve the low-frequency bandwidth of microphones. Additionally, this methodology could reduce the modulus and improve the sensitivity for the same resonant frequency, which typically indicates the maximum acoustic overload point (AOP).

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Objective: Fangcang shelter hospital is a form of large temporary hospital developed in China to tackle public health events. Through the case study and analysis of managing a nursing unit in a huge Fangcang shelter hospital transformed from the National Exhibition and Convention Center during the Omicron wave in Shanghai, China between April 9, 2022 and May 24, 2022, this paper aimed to highlight critical implications of public health nurses in health emergencies.

Design: A case study was conducted using data collected from a nursing unit with 570 beds.

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The expression of defensive responses to alerting sensory cues requires both general arousal and a specific arousal state associated with defensive emotions. However, it remains unclear whether these two forms of arousal can be regulated by common brain regions. We discovered that the medial sector of the auditory thalamus (ATm) in mice is a thalamic hub controlling both general and defensive arousal.

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The brain may sense, evaluate, modulate, and intervene in the operation of immune system, which would otherwise function autonomously in defense against pathogens. Antibody-mediated immunity is one arm of adaptive immunity that may achieve sterilizing protection against infection. Lymphoid organs are densely innervated.

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The development and utilization of urban underground space depend heavily on an understanding of urban geological conditions. The microtremor survey method is essential in urban geological surveys due to its quickness, convenience, non-destructiveness, and interference resistance. Since only the fundamental dispersion curves of Rayleigh waves can be obtained by utilizing the spatial autocorrelation method, the inversion results have multiple solutions.

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By eliminating the influence of the substrate on parasitic thermal resistance, MEMS suspended structures become one of the accurate nanoscale thermoelectric performance evaluation devices. However, the process of MEMS suspended thermoelectric devices is complex, and its multilayer suspended structure is easy to fracture due to large stress. As a result, optimizing the design of suspended structures is critical in order to reduce manufacturing complexity and increase yield.

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Sufficient samples of extreme precipitation events are needed in order to obtain reliable estimates of the probability of their occurrence. Here, we use a large ensemble simulation with 50 members from the Canadian Earth System Model (CanESM2) under the representative concentration pathway 8.5 (RCP8.

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Recent studies emphasize on developing immune tolerance by an interim administration of various immunosuppressive drugs. In this study, a robust protocol is reported for local immunomodulation using a single-dose of FK506 microspheres and clodronate liposomes (mFK+CLO) in a xenogeneic model of islet transplantation. Surprisingly, the single-dose treatment with mFK+CLO induce tolerance to the islet xenograft.

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To evaluate the relationship between coal-related carbon emissions (CCE) and economic growth, this paper analyzed the decoupling relationship between CCE and economic growth from national and provincial perspectives during period 1997-2016 through Tapio Decoupling Index. Then, to recognize its spatial characteristics during 1997-2016, gravity model was adopted to study the geographical changes of CCE. Finally, to identify the changes of (CCE) in China and reveal its internal driving forces, this paper employs the logarithmic mean Divisia index (LMDI) decomposition analysis to decompose decoupling indicator into six effects including emission factors, energy intensity, fossil energy structure, energy consumption structure, activity, and population at national and provincial levels.

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Background: Signal transduction pathways mediated by various receptors expressed on mast cells are thought to be complex, and inhibitory signals that turn off activating signals are not known.

Methods: Upstream signaling cascades mediated by several known receptors in bone marrow-derived mast cells that lead to degranulation and mediator release were studied by immunoblotting and immunoprecipitation. Small interfering RNAs and knockout mice were used to confirm findings.

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Article Synopsis
  • - The immune response poses challenges in cell-replacement therapy for type I diabetes, with long-term immunosuppression causing poor efficacy and side effects.
  • - Researchers developed "cell-particle hybrids" combining pancreatic islets with biodegradable microspheres coated in polydopamine and loaded with FK506 to locally control immune reactions at the transplant site.
  • - The study found that these hybrids released minimal FK506 to extend the survival of transplanted islets while minimizing systemic impact and reducing inflammation in the grafts, indicating a safer treatment option for type I diabetes.
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The function of regulatory T (T) cells depends on lipid oxidation. However, the molecular mechanism by which T cells maintain lipid metabolism after activation remains elusive. Liver kinase B1 (LKB1) acts as a coordinator by linking cellular metabolism to substrate AMP-activated protein kinase (AMPK).

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CD4 T cells differentiate into distinct effector subsets upon antigenic stimulation. Cytokines, and micro-environmental factors present during T-cell priming, direct differentiation of naïve CD4 T cells into pro-inflammatory Th1 and Th17 cells. From extensive screening of 2,4,5-trimethylpyridin-3-ol derivatives with various functional groups at C(6)-position, BJ-2266, a 6-thioureido-derivative, showed potent inhibitory activity on in vitro T helper (Th)-cell differentiation.

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CD4+ T cells are essential in inflammation and autoimmune diseases. Interferon-γ (IFN-γ) secreting T helper (Th1) and IL-17 secreting T helper (Th17) cells are critical for several autoimmune diseases. To assess the inhibitory effect of a given compound on autoimmune disease, we screened many compounds with an in vitro Th differentiation assay.

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