A low dissolved oxygen (DO) concentration in summer has been observed in river-estuary systems worldwide. Many studies have caused our stereotype that biochemical oxygen depletion was higher in summer than in winter; however, there was no direct evidence particularly in the tidal river with complex hydrological and biochemical processes. This study employed natural-abundance and labeled isotopes to quantify seasonal apportionment of biochemical oxygen depletion.
View Article and Find Full Text PDFCage-based MOFs, with their customizable chemical environments and precisely controllable nanospaces, show great potential for the selective adsorption of guest molecules with specific structures. In this work, we have constructed a novel cage-based MOF [(CH)NH][(UO)(TMTTA)]·11.5DMF·2HO (IHEP-51), utilizing a triazine derivative poly(carboxylic acid), 4,4',4″-(((1,3,5-triazine-2,4,6-triyl)tris(((4-carboxycyclohexyl)methyl)azanediyl))tris(methylene))tribenzoic acid (HTMTTA), as an organic ligand and uranyl as a metal node.
View Article and Find Full Text PDFBackground: Aripiprazole and risperidone, widely used atypical antipsychotics, are commonly adjunctively prescribed in clinical practice. When aripiprazole was combined with risperidone, the genotype of drug-metabolizing enzymes and liver impairment may lead to complex pharmacokinetic changes. The Physiologically Based Pharmacokinetic (PBPK) model can predict the influence of these factors on plasma concentration and optimize dosage regimens.
View Article and Find Full Text PDFBackground: Although the link between fine particulate matter (PM) and influenza-like illness (ILI) is well established, the effect of the chemical constituents of PM on ILI remains unclear. This study aims to explore this effect in Guangzhou, China.
Methods: Daily data on ILI cases, PM levels, and specific PM constituents (black carbon [BC], chlorine [Cl], ammonia [NH], nitrate [NO], and sulfate [SO]) in Guangzhou, China, were collected for the period of 2014-2019.
Metasurfaces have demonstrated significant potential in optical encryption and anti-counterfeiting due to their incredible capability of manipulating various light properties. However, previous metasurface-encryption methods did not sufficiently explore the spatial frequency aspect, particularly regarding evanescent waves. Here, we propose an encryption scheme by introducing evanescent waves into the encoding and decoding processes.
View Article and Find Full Text PDFThe fibrogenic conversion of satellite cells contributes to the atrophy and fibrosis of skeletal muscle, playing a significant role in the pathogenesis of age-related sarcopenia. Melatonin, a hormone secreted by the pineal gland, exhibits anti-aging and anti-fibrotic effects in various conditions. However, the effect of melatonin on satellite cell fate and age-related sarcopenia remains under-explored.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
March 2025
The oxidative Heck reaction of strongly coordinating heterocycles with internal olefins often led to elusive reactivity and regioselectivity. Herein, by judicious choice of X-type directing groups under Ru(ii) catalysis, we achieved the regioselective oxidative Heck reaction of strongly coordinating heterocycles with sterically demanding internal olefins. It was postulated that the "match/mismatch effect" of sterically demanding internal olefins as coupling partners and subsequent kinetically favoured Michael addition or oxidative aromatization act as driving forces to facilitate the desired reactivity and site-selectivity.
View Article and Find Full Text PDFWe reviewed research on SARS-CoV-2 and influenza virus detection on surfaces, their persistence under various conditions, and response to disinfectants. Viral contamination in community and healthcare settings was analyzed, emphasizing survival on surfaces influenced by temperature, pH, and material. Findings showed higher concentrations enhance survivability at room temperature, whereas stability increases at 4°C.
View Article and Find Full Text PDFPhase engineering of two-dimensional (2D) transition metal dichalcogenides (TMDs) is an attractive avenue to construct new surface-enhanced Raman scattering (SERS) substrates. Herein, 2D WS and MoS monolayers with high-purity distorted octahedral phase (1T') are prepared for highly sensitive SERS detection of analytes (e.g.
View Article and Find Full Text PDFThe creatine kinase (CK) is a key enzyme involved in brain bioenergetics, playing a key role in brain function and the pathogenesis of neurological and psychiatric diseases, but imaging its activity noninvasively in the human brain in vivo remains a significant challenge. This study aims to advance the magnetization transfer (MT)- P magnetic resonance fingerprinting (MRF) for 3D Creatine Kinase Imaging (CKI). The method was implemented and validated on a clinical 7 Tesla MRI scanner.
View Article and Find Full Text PDFHyperlipidemia is a common cause of acute pancreatitis (AP), often leading to more severe clinical symptoms. The mortality factor 4-like protein 1 (MORF4L1, also called MRG15) plays a crucial role in regulating lipid metabolism. Therefore, this study aimed to explore the mechanism of MRG15 in hyperlipidemic acute pancreatitis (HAP).
View Article and Find Full Text PDFspecies are capable of producing various active metabolites, including monacolin K (MK) and pigments. Studies have shown that the overexpression of the gene from the MK synthesis gene cluster in species can significantly increase MK production; however, the molecular mechanism has not yet been fully elucidated. Therefore, this study focused on the gene of to construct overexpression strains of the gene, resulting in high-yield MK production.
View Article and Find Full Text PDFThe environmental problems caused by the abuse of antibiotics are raising serious attention, and the removal of antibiotics in wastewater is meaningful yet challenging. In this work, lignin-derived carbon fibers loaded layered double hydroxides (LDH@LCF) has been prepared for the removal of ofloxacin (OFX) from wastewater via photocatalysis, which exhibit a high degradation efficiency of 96 % under visible light and maintained 90 % after five reuses. The effects of Zn/Fe in the samples and other parameters affecting the photocatalytic efficiency of OFX have been systematically investigated.
View Article and Find Full Text PDFIn 2009, severe fever with thrombocytopenia syndrome virus (SFTSV), also known as the (DBV), was first discovered in Henan, China. It is a tick-borne zoonotic virus with a fatality rate ranging from 6% to 30%. Currently, we lack safe and effective vaccines or antiviral drugs to treat SFTSV infection.
View Article and Find Full Text PDFA novel thioxoimidazolidin-linked sialoside bovine serum albumin (WM-BSA) conjugate was synthesized and evaluated as an inhibitor of influenza virus hemagglutinin (HA) and neuraminidase (NA). The multivalent conjugate was prepared by the attachment of thioxoimidazolidin-sialoside monomer (WM) to BSA via adipate linker. Surface plasmon resonance analysis revealed that WM-BSA exhibited potent binding to recombinant influenza HA and NA proteins, with dissociation constants in the submicromolar range.
View Article and Find Full Text PDFFourier ptychography (FP) is a high resolution wide-field imaging method based on the extended aperture in the Fourier space, which is synthesized from raw images with varying illumination angles. If FP is extended to coherent nonlinear optical imaging, the resolution could be further improved due to the increase of the cutoff frequency of the synthesized coherent optical transfer function (C-OTF) with respect to the order of nonlinear optical processes. However, there is a fundamental conflict between wide-field FP and nonlinear optical imaging, whereby the nonlinear optical imaging typically requires a focused excitation laser beam with high power density.
View Article and Find Full Text PDFThe community population based studies on the relationship between obstructive sleep apnea and liver injury are limited. The study aimed to clarify the association between sleep apnea (SA) and liver injury by using the data in The National Health and Nutrition Examination Survey. SA was assessed by the sleep questionnaire and liver injury was evaluated by liver function test, hepatic steatosis index, and fibrosis-4.
View Article and Find Full Text PDFPrevious studies on BSC2 have shown that it enhances yeast cell resistance to AmB via antioxidation and induces multidrug resistance by contributing to biofilm formation. Herein, we found that BSC2 overexpression could reverse the sensitivity of pmp3Δ to AmB and help the tested strains restore the intracellular sodium/potassium balance under exposure to AmB. Meanwhile, overexpression of the chitin gene CHS2 could simulate BSC2 to reverse the sensitivity of pmp3Δ and nha1Δ to high salt or AmB.
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