The Relationship Between A High-Fat Diet, Gut Microbiome, and Systemic Chronic Inflammation: Insights from Integrated Multi-Omics Analysis.

Background: The detrimental effects of a high-fat diet (HFD) extend beyond metabolic consequences and include systemic chronic inflammation (SCI), immune dysregulation, and gut health disruption.

Objectives: In this study, we used Mendelian randomization (MR) to investigate the relationship between HFD and gut microbiota, and SCI.

Methods: Genetic variants associated with dietary fat were utilized to explore causal relationships.

Molecular and Functional Characterization of the Peritoneal Mesothelium, a Barrier for Solute Transport.

Peritoneal dialysis (PD) is an increasingly needed, life-maintaining kidney replacement therapy; efficient solute transport is critical for patient outcome. While the role of peritoneal perfusion on solute transport in PD has been described, the role of cellular barriers is uncertain, the mesothelium has been considered irrelevant. We calculated peritoneal blood microvascular endothelial (BESA) to mesothelial surface area (MSA) ratio in human peritonea in health, chronic kidney disease, and on PD, and performed molecular transport related gene profiling and single molecule localization microscopy in two mesothelial (MC) and two endothelial cell lines (EC).

Histidine containing dipeptides protect epithelial and endothelial cell barriers from methylglyoxal induced injury.

Integrity of epithelial and endothelial cell barriers is of critical importance for health, barrier disruption is a hallmark of numerous diseases, of which many are driven by carbonyl stressors such as methylglyoxal (MG). Carnosine and anserine exert some MG-quenching activity, but the impact of these and of other histidine containing dipeptides on cell barrier integrity has not been explored in detail. In human proximal tubular (HK-2) and umbilical vein endothelial (HUVEC) cells, exposure to 200 µM MG decreased transepithelial resistance (TER), i.

Analysis and visualization of the research progress on surgical smoke.

Background: With the advancement of medical technology, tools such as electrosurgical equipment, laser knives, and ultrasonic scalpels have made modern medical procedures more convenient and effective. However, the generation of surgical smoke during these procedures poses significant health risks to medical personnel. Despite this, only a few studies have examined the literature systematically in this area.

Precisely targeted drug delivery by mesenchymal stem cells-based biomimetic liposomes to cerebral ischemia-reperfusion injured hemisphere.

The precise and targeted delivery of therapeutic agents to the lesion sites remains a major challenge in treating brain diseases represented by ischemic stroke. Herein, we modified liposomes with mesenchymal stem cells (MSC) membrane to construct biomimetic liposomes, termed MSCsome. MSCsome (115.

Total testosterone plays a crucial role in the pathway from hypothyroidism to broad depression in women.

Background: Depression tends to develop in correlation with hypothyroidism, however it's unclear how testosterone traits contribute to this association. We examined the causal association between depression, testosterone traits, and hypothyroidism using Mendelian randomization (MR).

Method: We conducted univariable and multivariable MR studies using summary-level statistics from genome-wide association studies (GWAS) of Hypothyroidism (n = 213,990), broad depression (n = 322,580), probable major depressive disorder (probable MDD) (n = 174,519), and International Classification of Diseases (ICD)-9 or ICD-10-coded MDD (n = 217,584) from European ancestry.

Breaking the Hoff/Le Bel rule by an electron-compensation strategy: the global energy minimum of NGaS.

In tetracoordinate chemistry, there is an attractive scientific problem of how to make the planar configuration more stable than the tetrahedral configuration. For tetracoordinate nitrogen, the abundant studies indicate that the planar tetracoordinate nitrogen (ptN) is far less stable than the tetrahedral tetracoordinate nitrogen (ttN). Herein, we introduced four S atoms to the unstable ptN-NGa and stable ttN-NGa by following an electron-compensation strategy.

Study on the Microstructure of Mg-4Zn-4Sn-1Mn-xAl As-Cast Alloys.

In this study, the microstructure of the Mg-4Zn-4Sn-1Mn-xAl (x = 0, 0.3 wt.%, denoted as ZTM441 and ZTM441-0.

Alternative splicing of IRF3 plays an important role in the development of hepatocarcinoma.

Alternative splicing is a process causing mRNA translation to produce different proteins, and it is crucial for the development of tumours. In this study, we constructed a prognostic model related to alternative splicing events in hepatocarcinoma using bioinformatics analysis, including the alternative splicing of CSAD, AFMID, ZDHHC16, and IRF3. The model is an independent prognostic factor and can accurately predict a patient's prognosis.

Self-Construction of Efficient Interfaces Ensures High-Performance Direct Ammonia Protonic Ceramic Fuel Cells.

Direct ammonia protonic ceramic fuel cells (PCFCs) are highly efficient energy conversion devices since ammonia as a carbon-neutral hydrogen-rich carrier shows great potential for storage and long-distance transportation when compared with hydrogen fuel. However, traditional Ni-based anodes readily suffer from severe structural destruction and dramatic deactivation after long-time exposure to ammonia. Here a Sr Fe Mo Cu O (SFMC) anode catalytic layer (ACL) painted onto a Ni-BaZr Ce Y Yb O (BZCYYb) anode with enhanced catalytic activity and durability toward the direct utilization of ammonia is reported.

The trigger for pancreatic disease: NLRP3 inflammasome.

NLRP3 inflammasome is a multiprotein complex expressed in a variety of cells to stimulate the production of inflammatory factors. Activation of NLRP3 inflammasome depends on a complex regulatory mechanism, and its pro-inflammatory function plays an important role in pancreatic diseases. In this literature review, we summarize the activation mechanism of NLRP3 and analyze its role in each of the four typical pancreatic diseases.

18-valence-electron rule lighted planar tetracoordinate carbon and nitrogen: the global energy minima of CAlZn and NAlZn.

The exploration of planar hypercoordinate carbon (phC) is challenging and significant. It is often puzzling to chemists whether the designed phC species should satisfy the 18-valence-electron rule, an authoritative rule in the phC field. In this study, we introduced a zinc atom into the extremely unstable 16-valence-electron planar tetracoordinate carbon (ptC) species CAl and its isoelectronic structure NAl with a planar tetracoordinate nitrogen (ptN), and designed the 18-valence-electron CAlZn and NAlZn possessing a ptC and ptN, respectively.

Association between trans fatty acids and COVID-19: A multivariate Mendelian randomization study.

Traditional observational studies have suggested a potential association between trans fatty acids (TFAs), which are considered to be health-damaging fatty acids, and coronavirus disease 2019 (COVID-19). However, whether there is a causal relationship between them is currently unclear. We aimed to investigate the causal link between genetically determined TFAs and COVID-19.

Genetic instability-related lncRNAs predict prognosis and influence the immune microenvironment in breast cancer.

Genome instability is a hallmark of cancer, and the function of lncRNAs in regulating genomic stability has been gradually characterized. However, the prognostic value of lncRNAs related to genetic instability has not been found in breast cancer. Here we constructed a genetic instability-related lncRNA model including U62317.

Evaluation of the local decoupling of livestock and cropland in the Huang-Huai-Hai region.

Decoupling livestock and cropland production at regional scale have poor resource-use efficiency and detrimental effects on environment in China. It is therefore necessary to identify the decoupled livestock and cropland production system and make recommendations to recouple livestock and cropland. This study used the indexes of land carrying capacity (LCC), animal manure absorption capacity (AMAC), and risk warning value (R) to evaluate the coupling between cropland and livestock at the local scale in the Huang-Huai-Hai region.

Precipitation Behavior of Mg-7Gd-3Y-2Zn-0.5Zr Alloy during Isothermal Aging.

Precipitate phases in an Mg-7Gd-3Y-2Zn-0.5Zr alloy aged isothermally at 240 °C were examined using high-resolution transmission electron microscopy (TEM) and high-angle annular dark-field scanning TEM. The two types of precipitation sequence that involve Mg-Gd and long period stacking ordered (LPSO) type were found.

Beyond the Intention: Individual-Level Determinants and Intergenerational Differences of Floating Populations' Actual Settlement Choices in Dongguan, China.

The migration process and patterns of floating populations have received continuing attention from scholars and policymakers. In China, however, studies have been focused on the settlement intention of floating populations based on sampling surveys and yielded inconsistent findings. Drawing upon 18,178,167 authentic individual samples of floating populations in Dongguan city, this study contributes to the literature by examining the effect of individual characteristics on the actual resident actions of floating populations, and revealing both the heterogeneity and continuity of their urban residence among four generations (i.

Peripheral Dopamine Controlled by Gut Microbes Inhibits Invariant Natural Killer T Cell-Mediated Hepatitis.

Neurotransmitters have been shown to regulate immune responses, and thereby are critically related to autoimmune diseases. Here we showed that depletion of dopaminergic neurons significantly promoted activation of hepatic iNKT cells and augmented concanavalin A (Con A)-induced liver injury. The suppressive effect of dopamine on iNKT cells was mediated by D1-like receptor-PKA pathway.

Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses.

Invariant NKT (iNKT) cells have been shown to help B cells in a cognate or noncognate manner; however, whether cognate iNKT cell help induces B cell memory responses remains controversial, and the underlying mechanisms are still unclear. In this study, we demonstrated that, in the absence of follicular helper T cells, cognate iNKT cell help could promote B cell memory responses in mice that were dependent on the formation of memory follicular helper iNKT (iNKT) cells and their interactions with memory B cells in recall responses. Generation of memory iNKT cells required lipid Ag presentation by dendritic cells but not by B cells.

The mutual restraint effect between the expansion of Alternanthera philoxeroides (Mart.) Griseb and cadmium mobility in aquatic environment.

Unlabelled: Alternanthera philoxeroides (Mart.) Griseb is one of the most malignant weeds in its invision habitats. While in the cadmium-contaminated aquatic environment, does A.