Synthesis of Ru-W/CeZrO catalyst with superior NH-SCO performance: Synergy between Ru and W species.

Ammonia selective catalytic oxidation (NH-SCO) is an effective method for NH removal. However, it is still a great challenge to develop catalysts with a wide operating temperature window, high catalytic activity and N selectivity, particularly for the removal of high-concentration NH from NH-fueled engine exhaust gas. Herein, a small amount of Ru (0.

Yes-Associated Protein Promotes Endothelial-Mesenchymal Transition to Mediate Diabetes Mellitus Erectile Dysfunction by Phosphorylating Smad3.

Purpose: The main objective of this study is to elucidate the role of endothelial-mesenchymal transition (EndMT) regulated by yes-associated protein (YAP) on diabetes mellitus erectile dysfunction (DMED).

Materials And Methods: High concentrations of glucose and palmitic acid (HGP) culturing simulated a diabetic condition . Cell proliferation, migration, tube formation, and marker gene changes of rat cavernous endothelial cells (RCECs) were measured after YAP overexpression or knockdown.

Molecular and spatial signatures of human and rat corpus cavernosum physiopathological processes at single-cell resolution.

The composition and cellular heterogeneity of the corpus cavernosum (CC) microenvironment have been characterized, but the spatial heterogeneity at the molecular level remains unexplored. In this study, we integrate single-cell RNA sequencing (scRNA-seq) and spatial transcriptome sequencing to comprehensively chart the spatial cellular landscape of the human and rat CC under normal and disease conditions. We observe differences in the proportions of cell subtypes and marker genes between humans and rats.

Integrative analysis of bulk and single-cell RNA sequencing reveals sphingolipid metabolism and immune landscape in clear cell renal cell carcinoma.

Clear cell renal cell carcinoma (ccRCC) is characterized by its aggressive behavior and complex molecular heterogeneity, posing significant challenges for treatment and prognostication. This study offers a comprehensive analysis of ccRCC by leveraging both bulk and single-cell RNA sequencing data, with a specific aim to unravel the complexities of sphingolipid metabolism and the intricate dynamics within the tumor microenvironment (TME). By examining ccRCC samples sourced from public databases, our investigation delves deep into the genetic and transcriptomic landscape of this cancer type.

Pt/AlO@Ce/ZrO-S bifunctional catalysts prepared by mechanically milling for selective catalytic oxidation of high-concentration ammonia.

The selective catalytic oxidation (SCO) is an effective method for removing slipped high-concentration ammonia from NH-fueled engine exhaust gas. Herein a novel bifunctional catalyst was synthesized by mechanically mixing sulfated Ce/ZrO (Ce/ZrO-S) with a small fraction of Pt/AlO (Pt 0.1 wt.

A multifunctional biomimetic nanoplatform for image-guideded photothermal-ferroptotic synergistic osteosarcoma therapy.

Much effort has been devoted to improving treatment efficiency for osteosarcoma (OS). However, most current approaches result in poor therapeutic responses, thus indicating the need for the development of other therapeutic options. This study developed a multifunctional nanoparticle, PDA-MOF-E-M, an aggregation of OS targeting, programmed death targeting, and near-infrared (NIR)-aided targeting.

Discrete residual diffusion model for high-resolution prostate MRI synthesis.

High-resolution magnetic resonance imaging (HR MRI) is an effective tool for diagnosing PCa, but it requires patients to remain immobile for extended periods, increasing chances of image distortion due to motion. One solution is to utilize super-resolution (SR) techniques to process low-resolution (LR) images and create a higher-resolution version. However, existing medical SR models suffer from issues such as excessive smoothness and mode collapse.

Arbitrary scale super-resolution diffusion model for brain MRI images.

Given the constraints posed by hardware capacity, scan duration, and patient cooperation, the reconstruction of magnetic resonance imaging (MRI) images emerges as a pivotal aspect of medical imaging research. Currently, deep learning-based super-resolution (SR) methods have been widely discussed in medical image processing due to their ability to reconstruct high-quality, high resolution (HR) images from low resolution (LR) inputs. However, most existing MRI SR methods are designed for specific magnifications and cannot generate MRI images at arbitrary scales, which hinders the radiologists from fully visualizing the lesions.

Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer's disease mice.

Sporadic or late-onset Alzheimer's disease (LOAD) accounts for more than 95% of Alzheimer's disease (AD) cases without any family history. Although genome-wide association studies have identified associated risk genes and loci for LOAD, numerous studies suggest that many adverse environmental factors, such as social isolation, are associated with an increased risk of dementia. However, the underlying mechanisms of social isolation in AD progression remain elusive.

Remarkable N selectivity enhancement of NH-SCO reactions over V/Pt/TiO catalyst through Cu-Er co-modification.

Pt-V bimetallic catalysts maybe promising substitutes to precious metal catalysts for selective catalytic oxidation (SCO) of NH. But it remains a major challenge for Pt-V bimetallic catalysts to pursue high NH conversion rate and N selectivity simultaneously. In this work, both Cu and Er were adopted to modify V/Pt/TiO catalyst (denoted as V/PT), and the influences of Cu and Er doping amounts on NH-SCO performance of V/PT catalysts were investigated systematically.

Deubiquitylase YOD1 regulates CDK1 stability and drives triple-negative breast cancer tumorigenesis.

Background: Accumulating evidence has demonstrated that aberrant expression of deubiquitinating enzymes is associated with the initiation and progression of Triple-negative breast cancer (TNBC). The publicly available TCGA database of breast cancer data was used to analyze the OTUD deubiquitinating family members that were correlated with survival of breast cancer and ovarian tumor domain-containing 2 (OTUD-2), or YOD1 was identified. The aim of present study was to assess YOD1 expression and function in human TNBC and then explored the underlying molecular events.

Assessment of Instant Loss of Elbow Flexion in Children with Untreated Gartland IIA Humeral Supracondylar Fractures-A Simulation Study with Lateral Elbow Radiographs.

Objective: The suitability of in situ cast fixation for treating Gartland IIA humeral supracondylar fractures has remained controversial due to concerns regarding loss of elbow flexion. This study aimed to assess the instant loss of elbow flexion after Gartland IIA humeral supracondylar fractures based on the relationship between the anterior marginal line of the humerus and capitellum in the lateral view.

Methods: This simulation study was conducted with normal radiographs using Adobe Photoshop 14.

Wen-Shen-Tong-Luo-Zhi-Tong Decoction regulates bone-fat balance in osteoporosis by adipocyte-derived exosomes.

Context: Wen-Shen-Tong-Luo-Zhi-Tong (WSTLZT) Decoction is a Chinese prescription with antiosteoporosis effects, especially in patients with abnormal lipid metabolism.

Objective: To explore the effect and mechanism of WSTLZT on osteoporosis (OP) through adipocyte-derived exosomes.

Materials And Methods: Adipocyte-derived exosomes with or without WSTLZT treated were identified by transmission electron microscopy, nanoparticle tracking analysis (NTA) and western blotting (WB).

BARX1 promotes osteosarcoma cell proliferation and invasion by regulating HSPA6 expression.

Osteosarcoma (OS) is a bone tumour affecting adolescents. Dysregulation of Barx homeobox 1 (BARX1) expression is involved in various cancers, but its function and mechanism in the process of OS are undefined. This study revealed that BARX1 expression is higher in OS tissue than in adjacent normal tissue.

Permethrin as a Potential Furin Inhibitor through a Novel Non-Competitive Allosteric Inhibition.

Furin is a potential target protein associated with numerous diseases; especially closely related to tumors and multiple viral infections including SARS-CoV-2. Most of the existing efficient furin inhibitors adopt a substrate analogous structure, and other types of small molecule inhibitors need to be discovered urgently. In this study, a high-throughput screening combining virtual and physical screening of natural product libraries was performed, coupled with experimental validation and preliminary mechanistic assays at the molecular level, cellular level, and molecular simulation.

A Novel Method Based on Hydrodynamic Cavitation for Improving Nitric Oxide Removal Performance of NaClO.

In the removal of nitric oxide (NO) by sodium chlorite (NaClO), the NaClO concentration is usually increased, and an alkaline absorbent is added to improve the NO removal efficiency. However, this increases the cost of denitrification. This study is the first to use hydrodynamic cavitation (HC) combined with NaClO for wet denitrification.

DJ-1 promotes osteosarcoma progression through activating CDK4/RB/E2F1 signaling pathway.

Osteosarcoma (OS) is a primary malignant tumor of the bone characterized by poor prognosis due to chemotherapy resistance and high recurrence rates. DJ-1 (PARK7) is known as an oncogene and its abnormal expression is related to the poor prognosis of various types of malignant tumors. It was found in this study that upregulated expression of DJ-1 was closely correlated with the prognosis of OS patients by promoting the proliferation, migration and chemotherapy resistance of OS cells through regulating the activity of CDK4 but not through the oxidation mechanism or AKT pathway.

Synthesis of W-modified CeO/ZrO catalysts for selective catalytic reduction of NO with NH.

In this paper, a series of tungsten-zirconium mixed binary oxides (denoted as W ZrO ) were synthesized co-precipitation as supports to prepare Ce/W ZrO catalysts through an impregnation method. The promoting effect of W doping in ZrO on selective catalytic reduction (SCR) performance of Ce/ZrO catalysts was investigated. The results demonstrated that addition of W in ZrO could remarkably enhance the catalytic performance of Ce/ZrO catalysts in a broad temperature range.

Cattle Encephalon Glycoside and Ignotin Ameliorate Palmitoylation of PSD-95 and Enhance Expression of Synaptic Proteins in the Frontal Cortex of a APPswe/PS1dE9 Mouse Model of Alzheimer's Disease.

Background: Synaptic abnormalities in synaptic proteins are the initial hallmarks of Alzheimer's disease (AD). The higher level of palmitoylation of synaptic proteins was closely associated with amyloid-β (Aβ) in AD. Cattle encephalon glycoside and ignotin (CEGI) have been shown to act as multitarget neurotrophic agents in APPswe/PS1dE9 (APP/PS1) transgenic AD mice.

Analysis of the location and trajectory of the Kirschner wires in the fixation of extension-type supracondylar fracture of the humerus by 3D computational simulation.

Background: Closed reduction and percutaneous pinning is still a preference for the treatment of supracondylar humerus fractures in children. However, no reports have shown the pin trajectory and the characteristics of the entry point so far. So we established a computational simulation model of the elbow to observe the trajectory of pinning for supracondylar humerus fractures.

Insight into the promoting effect of support pretreatment with sulfate acid on selective catalytic reduction performance of CeO/ZrO catalysts.

In this paper, sulfated ZrO were synthesized via precipitation and impregnation method, and the promoting effects of support sulfation on selective catalytic reduction (SCR) performance of CeO/ZrO catalysts were investigated. The results revealed that sulfated ZrO could significantly enhance the SCR activity of CeO/ZrO catalysts in a wide temperature range. Especially when S/Zr molar ratio was 0.

An investigation on the promoting effect of Pr modification on SO resistance over MnO catalysts for selective reduction of NO with NH.

Pr-modified MnO catalyst was synthesized through a facile co-precipitation process, and the results showed that MnPrO catalyst exhibited much better selective catalytic reduction (SCR) activity and SO resistance performance than pristine MnO catalyst. The addition of Pr in MnO catalyst led to a complete NO conversion efficiency in 120-220 °C. Moreover, Pr-modified MnO catalyst exhibited a superior resistance to HO and SO compared with MnO catalyst.

miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer's disease.

Aberrant regulation of microRNAs (miRNAs) has been implicated in the pathogenesis of Alzheimer's disease (AD), but most abnormally expressed miRNAs found in AD are not regulated by synaptic activity. Here we report that dysfunction of miR-135a-5p/Rock2/Add1 results in memory/synaptic disorder in a mouse model of AD. miR-135a-5p levels are significantly reduced in excitatory hippocampal neurons of AD model mice.