Conditional modeling of panel count data with partly interval-censored failure event.

In longitudinal follow-up studies, panel count data arise from discrete observations on recurrent events. We investigate a more general situation where a partly interval-censored failure event is informative to recurrent events. The existing methods for the informative failure event are based on the latent variable model, which provides indirect interpretation for the effect of failure event.

A communication failure and repair mechanism with adjustable transmission rates for PU packets in CRNs.

As one key technology of future radio communication networks, cognitive radio networks (CRNs) can effectively handle the shortage of network resources. Two classes of users exist in traditional CRNs, namely, primary users (PUs) with higher priority and secondary users (SUs) with cognitive ability. In CRNs, during the communication process, packets need to travel through various servers, such as switches and routers, and these devices may fail at any time.

On computation of semiparametric maximum likelihood estimators with shape constraints.

Large sample theory of semiparametric models based on maximum likelihood estimation (MLE) with shape constraint on the nonparametric component is well studied. Relatively less attention has been paid to the computational aspect of semiparametric MLE. The computation of semiparametric MLE based on existing approaches such as the expectation-maximization (EM) algorithm can be computationally prohibitive when the missing rate is high.

The Histone Methyltransferase Ash1l is Required for Epidermal Homeostasis in Mice.

Epidermal homeostasis under normal and healing conditions are critical for the physical and functional maintenance of the skin barrier. It requires a proper balance between keratinocyte proliferation and differentiation under genetic and epigenetic regulations. Here we show that mice carrying a hypomorphic mutation of the histone methyltransferase Ash1l [(absent, small, or homeotic)-like (Drosophila)] develop epidermal hyperplasia and impaired epidermal stratification upon aging.

Generation of a Mouse Full-length Balancer with Versatile Cassette-shuttling Selection Strategy.

Balancer chromosomes are important tools for a variety of genetic manipulations in lower model organisms, owing to their ability to suppress recombination. In mouse, however, such effort has not been accomplished, mostly due to the size of the chromosomes and the complexity of multiple step chromosomal engineering. We developed an effective and versatile cassette-shuttling selection (CASS) strategy involving only two selection markers to achieve the sequential production of multiple large inversions along the chromosome.