Publications by authors named "Zhisheng Long"
Article Synopsis
- Photodynamic therapy (PDT) can effectively erase bacterial biofilms in infected wounds but struggles due to low oxygen levels in these environments.
- This study created a novel wound dressing, CN-MnO/PLLA, which integrates manganese dioxide nanoparticles to enhance oxygen delivery and improve the efficacy of PDT.
- Results showed that this dressing significantly reduced biofilm density and bacterial counts, with over 99% wound healing achieved by Day 14, promoting essential cytokines for healing while reducing inflammation.
Article Synopsis
- Researchers developed a new type of osteotomy aimed at treating patients with osteoporotic vertebral fractures and neurological issues, arguing it is more effective than traditional methods like PSO and BDBO due to a reduced osteotomy range.
- The study utilized a finite element analysis to model and assess the biomechanical impact of these three osteotomy techniques on spinal structures, using data from a CT scan of a patient with an L1 fracture.
- Findings indicated the modified osteotomy exhibited improved stress and displacement outcomes compared to the BDBO method, which had poorer stability, suggesting postoperative care should be modified to avoid excessive load on the spine.
Article Synopsis
- This study addresses issues with dense hydroxyapatite (HAP) structures, like large grain size and low porosity, which negatively impact their use in bone integration.
- The researchers introduced hollow hydroxyapatite (hHAP) microspheres that have properties such as weak crystallization and increased surface area, which can enhance protein loading and osteoblast attachment.
- Additionally, experiments show that hHAP combined with chitosan (CS) scaffolds effectively supports bone remodeling and promotes healing by influencing calcium ion recruitment and inflammatory responses in stem cells.
Article Synopsis
- - Implant-associated infections are difficult to treat due to microbial biofilms; a new pH-responsive nanoplatform using zinc sulfide nanoparticles on TiC MXene nanosheets shows promise in combating these infections.
- - The nanoplatform releases hydrogen sulfide gas in acidic biofilm conditions, breaking down biofilm extracellular DNA and making it susceptible to heat; this works even better when combined with near-infrared light for enhanced photothermal effects.
- - The composite scaffold not only significantly reduces biofilm formation and eradicates existing biofilms but also encourages the growth and differentiation of bone cells, indicating its potential as a treatment for implant-related bone infections.
Article Synopsis
- * This research focused on the impact of exosomes from osteoblasts (bone cells) on osteosarcoma, finding that these exosomes can inhibit cancer cell growth and encourage mineralization (bone formation).
- * The study revealed that osteoblast-derived exosomes work through the URG4/Wnt signaling pathway by enhancing certain protein expressions and inhibiting others, offering insight into potential new treatments for osteosarcoma.
Article Synopsis
- Tendon-exposed wounds are complex injuries with difficult healing processes due to insufficient tissue and poor blood circulation, leading to increased pain for patients and stress for their families and caretakers.* -
- Recent advances in medical research have led to new treatment methods alongside traditional surgical approaches, including innovative dressing techniques, vacuum sealing therapies, and platelet-rich plasma treatments.* -
- The review aims to summarize the latest findings in treating tendon-exposed wounds to enhance treatment options and outcomes for affected individuals.*
Article Synopsis
- - The study investigates a simplified surgical method, modified posterior osteotomy, to treat elderly patients with osteoporotic vertebral collapse and delayed neurological dysfunction, aiming to improve clinical outcomes.
- - A total of 12 patients with an average age of 65.5 years participated, and metrics such as pain levels and disability were significantly improved post-surgery, with a notable decrease in the visual analogue scale (VAS) score and Oswestry Disability Index (ODI).
- - Results indicate that while the procedure had a significant average operative time of 3.7 hours and blood loss of approximately 483.3 ml, the overall clinical efficacy and safety of the modified technique showed promising outcomes for this patient demographic.
Article Synopsis
- Bone tissue engineering aims to treat bone defects but faces challenges in creating materials that effectively recruit bone marrow mesenchymal stem cells (BMSCs) for regeneration.
- Hollow hydroxyapatite microspheres (HHMs) alone have limited ability to recruit BMSCs, so this study developed biomimetic scaffolds (HHM/chitosan and rhCXCL13-HHM/CS) that enhance bone regeneration.
- The rhCXCL13-HHM/CS scaffold successfully recruited BMSCs and promoted bone growth through the PI3K-AKT pathway, showing significant improvement in bone healing in a rabbit model over 12 weeks.
Study on the influence of scaffold morphology and structure on osteogenic performance.
Front Bioeng Biotechnol
March 2023
Article Synopsis
- * Current treatments often use cytokines for promoting fracture healing, but they can trigger immune responses and are costly, resulting in less effective clinical outcomes.
- * New research is focusing on tissue-induced biomaterials that promote bone regeneration through optimized scaffold structures, potentially improving tissue-engineered bones without the need for expensive cytokine additions.
Article Synopsis
- - Plasmacytoma is a rare condition involving plasma cell growth in bones or soft tissues, with types including solitary bone and extramedullary plasmacytomas; it can occur alongside chronic conditions like osteomyelitis.
- - A 47-year-old man with a history of chronic osteomyelitis experienced ulceration in his tibia, leading to imaging tests that revealed dead bone and inflammation, prompting surgical intervention.
- - Post-surgery, the diagnosis was confirmed as plasmacytoma, and the patient received successful radiotherapy; this case emphasizes the need for careful monitoring of chronic osteomyelitis for possible plasmacytoma development.
Article Synopsis
- The study investigates the use of platelet-rich plasma (PRP) as a treatment for severe wounds with exposed tendons, addressing a significant clinical issue in wound healing.
- A total of 12 patients with refractory wounds were treated with PRP injections following debridement, showing a healing time of about 23 days and significant improvements in scar assessment scores.
- Results indicated that PRP therapy not only sped up healing and reduced inflammation but also improved tissue quality, with high patient satisfaction reported during follow-up.
Article Synopsis
- A 22-year-old man suffered a comminuted patellar fracture after a traffic accident, which made it difficult to repair due to the complexity of the fracture.
- The treatment involved using multiple 3D-printed guide plates to assist in the reduction and fixation of the fracture.
- Over a 2-year follow-up, the patient experienced good recovery without significant limitations in knee function, highlighting the effectiveness of this innovative technique in surgical treatment.
Article Synopsis
- Circular RNAs (circRNAs) like circ_0000285 play a significant role in the progression of diseases, including osteosarcoma (OS), but their functions are not completely understood.
- Researchers found that circ_0000285 expression was higher in OS tissues and that knocking it down can reduce OS growth through various assays.
- The study revealed that circ_0000285 influences OS cell behavior by interacting with miR-409-3p and the protein IGFBP3, suggesting that targeting circ_0000285 could be a therapeutic strategy for OS.
Article Synopsis
- Autogenous and allogenic bone transplantation are common methods for treating bone issues, but they have limitations that affect their widespread use in medicine.
- This study tests PLGA microspheres carrying pOsterix/PEI nanoparticles to see if they can effectively repair bone defects and investigates how they work.
- Results show that PLGA@pOsx/PEI is safe, boosts important proteins for bone formation, and promotes bone healing in models, suggesting it could be a useful material for clinical bone repair.
Article Synopsis
- The text discusses the challenges of surgically treating penetrating trauma to the buttock due to its complex anatomy.
- It presents two cases where patients underwent successful surgery using spinal endoscopy, a minimally invasive technique.
- Both patients had their drainage tubes removed within a week, healed well, and were discharged from the hospital in less than two weeks, indicating effective treatment when major structures were not injured.
Article Synopsis
- The study investigated how a composite made of hollow hydroxyapatite microspheres and chitosan can deliver recombinant proteins rhBMP-2 and rhCXCL13 for bone repair.
- Findings showed that rhBMP-2 enhances the proliferation and differentiation of bone marrow stem cells, while rhCXCL13 promotes their migration, leading to improved bone healing.
- The research suggests that this composite could be a promising method for bone regeneration by effectively delivering these proteins to enhance the body's repair mechanisms.