Causal relationship between gut microbiota and polycystic ovary syndrome: a literature review and Mendelian randomization study.

Introduction: Numerous studies have suggested an association between gut microbiota and polycystic ovarian syndrome (PCOS). However, the causal relationship between these two factors remains unclear.

Methods: A review of observational studies was conducted to compare changes in gut microbiota between PCOS patients and controls.

Diagnostic and prognostic risk factors analysis for distant metastasis in melanoma: a population-based study.

Background: We aimed to develop tools that could predict the occurrence of distant metastases in melanoma and its prognosis based on clinical and pathological characteristics.

Materials And Methods: We obtained data from the Surveillance, Epidemiology, and End Results (SEER) database of melanoma patients diagnosed between 2010 and 2019. Logistic analyses were performed to identify independent risk factors associated with distant metastasis.

LncRNA linc01116 prometes glioma cell migration and invasion by modulation of radixin targeted by miR-31.

Background: Long non-coding RNA (lncRNA) linc01116 was found to be abnormally expressed in many malignant tumor tissues and involved in cancer progression, but its expression and role in glioma tissue is still unclear. This study was designed to investigate the expression of linc01116 in glioma tissues and the role of linc01116 in glioma cell migration and invasion.

Methods: Linc01116 and miR-31 expression was measured in 135 cases of human glioma tissues and normal brain tissues using Real-time quantitative PCR (RT-qPCR).

Contralateral Approach to Paraclinoid Aneurysms: Angiographic Analysis and Surgical Results of 12 Patients.

Background And Study Aims:  To explore the usefulness of a unilateral approach for clipping multiple aneurysms including a contralateral paraclinoid aneurysm.

Materials And Methods:  Between January 2011 and May 2016, the unilateral approach was used to clip a contralateral paraclinoid aneurysm plus additional ipsilateral aneurysms. The records of these patients were analyzed retrospectively.

Comparison between frontolateral approach and pterional approach in the surgical treatment of paraclinoid aneurysms.

Objective: To compare the pterional and frontolateral approach to determine the most effective route for paraclinoid aneurysm surgery.

Methods: Between June 2010 and December 2015, a total of 176 patients with paraclinoid aneurysm underwent surgical clipping, 96 through the pterional and 80 through the frontolateral approach. We analyzed the two groups and compared demographic, radiologic, and clinical variables including age, sex, aneurysm type,intraoperative rupture rates, operative time,anatomical obstacles,outcome and postoperative complications.

Dynamics of Zebrafish Heart Regeneration Using an HPLC-ESI-MS/MS Approach.

Failure to properly repair damaged due to myocardial infarction is a major cause of heart failure. In contrast with adult mammals, zebrafish hearts show remarkable regenerative capabilities after substantial damage. To characterize protein dynamics during heart regeneration, we employed an HPLC-ESI-MS/MS (mass spectrometry) approach.

Microsurgical treatment of carotid-ophthalmic aneurysm associated with multiple anterior and posterior circulation aneurysms: A case report.

Background: The clipping of multiple intracranial aneurysms in 1 stage is uncommon. In this case, we report clipping of an ophthalmic aneurysm associated with multiple anterior and posterior circulation aneurysms via the Dolenc approach.

Methods: The main symptoms of the patient are headache, along with nausea and vomiting.

Intracranial mesenchymal chondrosarcoma: case report and literature review.

Background: Mesenchymal chondrosarcoma is a very rare malignant cartilaginous forming tumour in central nervous system (CNS), which is rarely encountered in clinical practice and generally occurs in young adults. This article describes a case of primary intracranial mesenchymal chondrosarcoma in a 31-year-old woman and reviews the literature on its manifestations and management.

Case Report: This patient had suffered from severe headache, intermittent nausea and vomiting for 1 week.

Progesterone increases circulating endothelial progenitor cells and induces neural regeneration after traumatic brain injury in aged rats.

Vascular remodeling plays a key role in neural regeneration in the injured brain. Circulating endothelial progenitor cells (EPCs) are a mediator of the vascular remodeling process. Previous studies have found that progesterone treatment of traumatic brain injury (TBI) decreases cerebral edema and cellular apoptosis and inhibits inflammation, which in concert promote neuroprotective effects in young adult rats.

Hepatocyte nuclear factor-4 mediates apolipoprotein A-IV transcriptional regulation by fatty acid in newborn swine enterocytes.

Hepatocyte nuclear factor-4alpha (HNF-4alpha) regulates transcription of several genes involved in lipid metabolism, including that of apolipoprotein (apo) A-IV, which is tightly regulated by lipid absorption and enhances enterocyte chylomicron secretion. Studies were performed to define the role of HNF-4alpha in the regulation of apo A-IV gene transcription by dietary fatty acid in neonatal swine small intestine. HNF-4alpha mRNA was expressed in liver > intestine > kidney in suckling, weanling, and weaned pigs.