Publications by authors named "Zhiru Li"

Background: Living liver donors are frequently used for liver transplantation, but they experience many physical changes and psychological challenges. A better understanding of the experiences of liver donors can provide them with comprehensive and individualized patient-centred support and health care. Thus, this study sought to identify and synthesize existing qualitative studies to develop an in-depth understanding of the lived experiences of living liver donors.

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Background: With advances in medical technologies, more children with chronic diseases are now living on into adulthood. The development of proficient self-management skills is essential for adolescents and young adults to transition from pediatric to adult health care services. An innovative way to improve the current care model and foster self-management skills could be through eHealth or mHealth (mobile health) interventions, in particular, when considering the rising ownership of digital technology by adolescents and young adults.

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Background: Abnormalities in mitochondrial structure or function are closely related to the development of malignant tumors. Mitochondrial metabolic reprogramming provides precursor substances and energy for the vital activities of tumor cells, so that cancer cells can rapidly adapt to the unfavorable environment of hypoxia and nutrient deficiency. Mitochondria can enable tumor cells to gain the ability to proliferate, escape immune responses, and develop drug resistance by altering constitutive junctions, oxidative phosphorylation, oxidative stress, and mitochondrial subcellular relocalization.

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The effect of an oriented external electric field (EEF) on materials has led to the ongoing development, which stimulates us to consider whether intracage microelectric fields (IMEFs) can be used to substitute for the EEF. Focusing on the manipulation and evaluation of the IMEF of asymmetric molecular containers, the host-guest compounds of interesting pineapple-shaped Y@CX (X = vacant, Cl, F, and H; Y = NHCl, HO-Cl, and 2HO) are theoretically constructed and the strength of the IMEF was evaluated by the intrapotential energy surface analysis by using the point charge ( = +1) scanning method. Interestingly, the left and right halves of each cage are like two IMEFs connected in reverse series.

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Objectives: This study aimed to assess the knowledge, attitudes, and practices (KAP) and the training requirements of pediatric intensive care nurses regarding intra-abdominal pressure (IAP) monitoring, in order to provide a reference for the development of relevant training programs and operational procedures in clinical practice.

Methods: This descriptive cross-sectional survey was conducted from April 2023 to June 2023. A convenience sample was created by recruiting 212 pediatric intensive care nurses in eight hospitals in Zhejiang Province.

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Aims: Renal fibrosis is a common feature in various chronic kidney diseases (CKD). Tubular cell damage is a main characterization which results from dysregulated fatty acid oxidation (FAO) and lipid accumulation. Cannabinoid Receptor 2 (CB2) contributes to renal fibrosis, however, its role in FAO dysregulation in tubular cells is not clarified.

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Background: With the rapid advancement of medical imaging technologies, precise image analysis and diagnosis play a crucial role in enhancing treatment outcomes and patient care. Computed tomography (CT) and magnetic resonance imaging (MRI), as pivotal technologies in medical imaging, exhibit unique advantages in bone imaging and soft tissue contrast, respectively. However, cross-domain medical image registration confronts significant challenges due to the substantial differences in contrast, texture, and noise levels between different imaging modalities.

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Background: Treatment efficacy may differ among patients with nasopharyngeal carcinoma (NPC) at similar tumor-node-metastasis stages. Moreover, end-of-treatment tumor regression is a reliable indicator of treatment sensitivity. This study aimed to investigate whether quantitative dual-energy computed tomography (DECT) parameters could predict sensitivity to neck-lymph node radiotherapy in patients with NPC.

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Acute kidney injury (AKI) is in high prevalence worldwide but with no therapeutic strategies. Programmed cell death in tubular epithelial cells has been reported to accelerate a variety of AKI, but the major pathways and underlying mechanisms are not defined. Herein, we identified that pyroptosis was responsible for AKI progression and related to ATP depletion in renal tubular cells.

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Background And Purpose: To investigate the effect of combining Endostar with concurrent chemoradiotherapy (ECCRT) compared to concurrent chemoradiotherapy (CCRT) on the regression rate of retropharyngeal lymph nodes (RLNs) and the relationship between regression rate of RLNs and prognosis of patients with locally advanced nasopharyngeal carcinoma (LANPC).

Methods: A total of 122 LANPC patients with RLNs metastasis were included. Metastatic RLNs were delineated both before and after treatment slice by slice on the magnetic resonance images cross-section.

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The clinical significance of the combination of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) is unclear. This study investigated the predictive value of pretreatment NLR (pre-NLR) combined with pretreatment PLR (pre-PLR) for the survival and prognosis of nasopharyngeal carcinoma (NPC). A total of 765 patients with non-metastatic NPC from two hospitals were retrospectively analyzed.

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Article Synopsis
  • The study explores parents' feelings and experiences when transitioning their children from intensive care to a general ward after liver transplantation, aiming to guide better support strategies.
  • Through interviews with thirteen parents, three main themes emerged: the emotional struggle of separation, the overwhelming responsibilities of caregiving, and the need for information and support as they adapt to a new normal.
  • The findings emphasize the importance of providing tailored information and educational resources to help parents manage their caregiving roles during this challenging transition.
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Aim: To provide a comprehensive overview on emerging direct and alternative methods for intra-abdominal pressure (IAP) measurement techniques.

Methods: This was a scoping review study following Arksey and Malley's framework. The PubMed, EMBASE, Web of Science, EBSCO, Scopus and ProQuest databases were searched, and we only considered studies published from 2000 as we have extended the data from two previous reviews.

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Patients with gastroesophageal reflux disease (GERD) are more likely to develop esophageal cancer (EC). However, a causal relationship between the 2 has been difficult to determine. Therefore, this study aimed to evaluate the impact of GERD on EC using the Mendelian randomization (MR) method.

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Relighting facial images based on estimated lighting distribution and intensity from image backgrounds and environments can lead to more natural and convincing effects across diverse settings. In this paper, we introduce the Light Estimation for Implicit Face Relight Network (LEIFR-Net), which we believe to be a novel approach that significantly improves upon current methodologies. Initially, we present a method to estimate global illumination from a single image.

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Meat adulteration has brought economic losses, health risks, and religious concerns, making it a pressing global issue. Herein, combining the high amplification efficiency of polymerase chain reaction (PCR) and the accurate recognition of CRISPR/Cas12, a sensitive and reliable electrochemiluminescence (ECL) biosensor was developed for the detection of pufferfish authenticity using NiCoO NCs@Au-ABEI as nanoemitters. In the presence of target DNA, the trans-cleavage activity of CRISPR/Cas12a is activated upon specific recognition by crRNA, and then it cleaves dopamine-modified single stranded DNA (ssDNA-DA), triggering the ECL signal from the "off" to "on" state.

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Renal fibrosis, with no therapeutic approaches, is a common pathological feature in various chronic kidney diseases (CKD). Tubular cell injury plays a pivotal role in renal fibrosis. Commonly, injured tubular cells exhibit significant lipid accumulation.

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To identify superalkali-alkaline earthide ion pairs, it's theoretically shown that, as a novel class of excess electron superalkali compounds, both chair and boat forms of (AM-HMHC)-AM' (AM = Li, Na, and K; AM' = Be, Mg, and Ca; HMHC = 1,4,7,10,13,16-hexamethyl-1,4,7,10,13,16-hexaazacyclooctadecane) are good candidates. An attractive superalkali-alkaline earthide ion pair in (AM-HMHC)-AM' is firstly exhibited, which possesses alkaline-earthide characteristics and nonlinear optical response superior to similar M(calix[4]pyrrole)M' (M = Li, Na, and K; M' = Be, Mg, and Ca) with high stability. The electronic and vibrational second order hyperpolarizabilities and the frequency-dependent first hyperpolarizabilities of (AM-HMHC)-AM' are presented.

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Article Synopsis
  • Researchers developed a dual-mode paper-based aptasensor using gold nanoparticles and porous carbon-zinc oxide to detect AFB effectively through both electrochemical and photoelectrochemical methods.
  • The sensor demonstrated a wide detection range and low limits of detection, along with high selectivity and stability, indicating its potential for ensuring food safety.
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Background: In recent years, pegylated liposomal doxorubicin (PLD) has been widely used to improve the survival of patients with ovarian cancer; however, it is unclear whether the combinational use of PLD with other drugs is more effective. Therefore, this meta-analysis aimed to confirm the efficacy and safety of trabectedin, combined with PLD, in the treatment of recurrent ovarian cancer.

Methods: Data corresponding to all eligible clinical trials as of May 15, 2022, was retrieved using several electronic retrieval databases including PubMed, Medical Literature Analysis and Retrieval System Online (MEDLINE), ClinicalTrials.

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The sensitive and accurate detection of ochratoxin A (OTA) is crucial for public health due to its high toxicity. Herein, using Au nanoparticle (NP)-attached CdS/UiO-66-NH heterostructures as photoactive materials, a photoelectrochemical (PEC) aptasensor was presented for the ultrasensitive assay of OTA based on a competitive displacement reaction triggering the trans-cleavage ability of CRISPR/Cas12a. In this sensing strategy, methylene blue-labeled single-stranded DNA (MB-ssDNA) was immobilized on the Au NPs/CdS/UiO-66-NH electrode to accelerate the separation of the photogenerated carrier, thus producing a significantly increased PEC response.

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Article Synopsis
  • - Mpox, a neglected zoonotic disease prevalent in West and Central Africa, has seen over 90,000 cases globally since 2022, raising concerns for future outbreaks and emphasizing the urgent need for quick diagnostic tests.
  • - The Mpox virus (MPV) belongs to the Orthopoxvirus genus, which includes other well-known viruses like variola (smallpox) and vaccinia, and recent phylogenomic analyses have identified distinct groups within these viruses highlighting their zoonotic potential.
  • - Researchers developed a user-friendly colorimetric LAMP assay to detect Old World OPVs and created a specific probe for MPV, along with an extraction-free protocol allowing for efficient testing even in low-resource environments, enhancing rapid
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