Publications by authors named "Zhirong Wan"
Article Synopsis
- Early diagnosis of α-synucleinopathies like Parkinson's disease is difficult but important.
- Researchers created a specialized test to analyze microRNA in extracellular vesicles from blood plasma, studying over 1200 participants, including healthy individuals and those with sleep disorders or other related conditions.
- Findings showed elevated levels of a specific microRNA (miR-44438) in patients with α-synucleinopathies, which could help in early detection and tracking disease progression over time.
Background: Parkinson's disease (PD) affects 1% of people over 60, and long-term levodopa treatment can cause side effects. Early diagnosis is of great significance in slowing down the pathological process of PD. Multiple pieces of evidence showed that non-coding RNAs (ncRNAs) could participate in the progression of PD pathology.
View Article and Find Full Text PDFDepression is one of the early and most persistent non-motor symptoms of Parkinson's disease (PD), which remains ignored, resulting in the underdiagnosis of PD. Unfortunately, scarce studies and the non-availability of diagnostic strategies cause countless complications, highlighting the need for appropriate diagnostic biomarkers. Recently, brain-enriched miRNAs regulating vital neurological functions have been proposed as potent biomarkers for therapeutic strategies.
View Article and Find Full Text PDFCerebellar infarction caused by vertebral artery dissection: A case report.
Medicine (Baltimore)
June 2023
Rationale: Vertebral artery dissection is an important cause of posterior circulation ischemic stroke in young and middle-aged people. We reported a young man with cerebellar infarction caused by dissection of the right vertebral artery.
Patient Concerns: A 34-year-old man presented with intermittent dizziness, blurred vision, nausea, and transient tinnitus 10 days before admission.
Article Synopsis
- Non-motor symptoms (NMS) are essential for diagnosing multiple system atrophy (MSA) and can appear before motor symptoms, but few studies have focused on their timing and differences compared to Parkinson's disease (PD) and progressive supranuclear palsy (PSP).
- The study involved 61 patients with MSA, 87 with PD, and 30 with PSP, using the Non-Motor Symptoms Scale (NMSS) to assess the prevalence and timing of NMS in MSA relative to motor symptom onset.
- Results showed that MSA patients had significantly more NMS than those with PD and PSP, with certain symptoms like fainting and lack of motivation indicating MSA, while issues like forgetfulness were
Endogenous neurotoxin 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroiso-quinoline (Salsolinol, SAL) is a dopamine metabolite that is toxic to dopaminergic neurons in vitro and in vivo, and is involved in the pathogenesis of Parkinson's disease (PD). However, the molecular mechanism by which SAL induces neurotoxicity in PD remains challenging for future investigations. This study found that SAL induced neurotoxicity in SH-SY5Y cells and mice.
View Article and Find Full Text PDFEpigallocatechin 3-gallate (EGCG), an abundant polyphenolic component derived from green tea extract, possesses versatile bioactivities that can combat many diseases. During the last decade, EGCG was shown to be effective in experimental models of Parkinson's disease (PD). Several experimental studies have suggested that it has pleiotropic neuroprotective effects, which has enhanced the appeal of EGCG as a therapeutic strategy in PD.
View Article and Find Full Text PDFObjective: To investigate the risk factors of motor complications in female patients with Parkinson's disease (PD) and the correlation between the occurrence of motor complications and sex hormone levels.
Methods: According to the occurrence and types of motor complications, 103 female PD patients were divided into two groups: patients with or without the wearing-off phenomenon, patients with or without dyskinesia. Binary logistic regression analysis was performed respectively to screen for the risk factors of the wearing-off phenomenon and dyskinesia in female PD patients.
Objective: To shed light on the association between restless leg syndrome (RLS) and anxiety in Parkinson's disease (PD) population.
Methods: This was a case-control study including 129 PD participants with and without anxiety who presented to the Aerospace Center Hospital in Beijing, China. Anxiety was evaluated by using the Beck Anxiety Index score.
Effects of Health Qigong Exercises on Physical Function on Patients with Parkinson's Disease.
J Multidiscip Healthc
April 2021
Purpose: To measure motor function improvements in patients with Parkinson's disease (PD) using Health Qigong exercises.
Patients And Methods: Fifty-two PD patients (Hoehn and Yahr stages I to IV) were randomly divided into experimental and control groups. Twenty-six PD patients in the experimental group were intervened with routine medicine and fitness Qigong exercise.