Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence.

Specific identification and monitoring of senescent cells are essential for the in-depth understanding and regulation of senescence-related life processes and diseases. Fluorescent sensors providing real-time and in situ information with spatiotemporal resolution are unparalleled tools and have contributed greatly to this field. This review focuses on the recent progress in fluorescent sensors for molecularly targeted imaging and real-time tracking of cellular senescence.

Mussel-Inspired Caries Management Strategy: Constructing a Tribioactive Tooth Surface with Remineralization, Antibiofilm, and Anti-inflammation Activity.

Dental caries is a common chronic oral disease in humans resulting from tooth demineralization caused by acid production of bacterial plaque, which leads to the destruction of enamel and dentin and oral inflammation. However, it is still a challenge that the function of natural active ingredients in currently available oral care products is not comprehensive, especially the lack of remineralization. Here, inspired by the strong biological adhesion ability of mussels and ancient oral disease plant therapy, a multifunctional strategy is proposed to construct a bioactive tooth surface to treat dental caries.

Improving Anti-listeria Activity of Thymol Emulsions by Adding Lauric Acid.

In this study, a novel emulsion, thymol (Thy) and lauric acid (LA) emulsion (Thy/LA-Emulsion) was prepared by homogenizing eutectic solvent (Thy/LA mixture) and caseinate solution. The effects of different thymol and lauric acid mass ratio on the formation, stability, and antibacterial activity of emulsions were studied. Compared with thymol alone, adding lauric acid (25, 50, and 75%) could enhance the antibacterial efficacy of the emulsions.

Interfering TUG1 Attenuates Cerebrovascular Endothelial Apoptosis and Inflammatory injury After Cerebral Ischemia/Reperfusion via TUG1/miR-410/FOXO3 ceRNA Axis.

Background Emerging studies illustrate that long non-coding RNA TUG1 (TUG1) participates in neuron death after ischemia. However, the role of TUG1 in cerebral ischemia/reperfusion (CI/R) injury through cerebrovascular pathology was undetermined yet. Methods Expression of TUG1, miRNA-410-3p (miR-410), and forkhead box O3 (FOXO3) was detected by RT-qPCR and western blot.

Selective detection of glutathione by flower-like NiVO with only peroxidase-like activity at neutral pH.

In view of the broad application prospect of peroxidase-like nanozymes in biomedical analysis, it is of great significance to eliminate the interference of their oxidase-like activity and enable them to work under neutral conditions. Herein, flower-like NiVO was synthesized and their enzyme-mimicking activity was investigated. Through the regulation of pH, NiVO nanozyme showed only peroxidase-like activity but not oxidase-like activity under neutral conditions, which could catalyze the oxidation of colorless 3,3',5,5'-tetramethylbenzidine into its blue product in the presence of HO.

Effect of Fe Addition on Microstructure and Mechanical Properties of As-cast TiNi Alloy.

Effect of Fe addition on microstructure and mechanical properties of as-cast TiNi alloy were investigated. The experimental results shows the microstructures of TiNiFe and TiNiFe alloys are mainly composed of TiNi matrix phase (body-centered cubic, BCC), TiNi and NiTi phases; the microstructure of TiNiFe alloy is mainly composed of BCC TiNi, TiNi, NiTi, and NiTi phases; the microstructure of the TiNiFe alloy is mainly composed of TiNi, TiNi and NiTi phases. The NiTi nanocrystalline precipitates at the adjacent position of NiTi phase.

Effect of Heat Treatment Temperature on Martensitic Transformation and Superelasticity of the TiNi Shape Memory Alloy.

The martensitic transformation and superelasticity of TiNi shape memory alloy heat-treatment at different temperatures were investigated. The experimental results show that the microstructures of as-cast and heat-treated (723 K) Ni-rich TiNi samples prepared by rapidly-solidified technology are composed of B2 TiNi phase, and TiNi and TiNi phases; the microstructures of heat-treated TiNi samples at 773 and 823 K are composed of B2 TiNi phase, and of B2 TiNi and TiNi phases, respectively. The martensitic transformation of as-cast TiNi alloy is three-stage, A→R→M and R→M transformation during cooling, and two-stage, M→R→A transformation during heating.

Implementation of CsLIS/NES in linalool biosynthesis involves transcript splicing regulation in Camellia sinensis.

Volatile terpenoids produced in tea plants (Camellia sinensis) are airborne signals interacting against other ecosystem members, but also pleasant odorants of tea products. Transcription regulation (including transcript processing) is pivotal for plant volatile terpenoid production. In this study, a terpene synthase gene CsLIS/NES was recovered from tea plants (C.

[Determination of trace barium in mineral water with oxygen enriched air-acetylene flame in atomic absorption spectrometry].

In this paper, the determination of Ba using oxygen enriched air-acetylene flame in AAS has been studied and the effect of acetylene flow, oxygen flow and the ratio of O2/C2H2 on the absorbance have been compared. When the amount of oxygen is 52% in mixed gas and the ratio of O2/C2H2 is about 0.72, higher sensitivity for Ba can be obtained.