Publications by authors named "Zhiqun Zhao"
Article Synopsis
- Breast cancer patients often face treatment resistance due to chemoresistant breast cancer stem cells (BCSCs), which contribute to cancer recurrence and spread.
- Researchers developed an mRNA-based BCSC signature using machine learning to assess cancer stemness in patient samples and discovered that polyamine anabolism, influenced by the HIF-1 transcription factor, plays a crucial role in enhancing BCSC levels following chemotherapy.
- A natural compound, britannin, was found to inhibit HIF-1 activity, leading to reduced polyamine production and BCSC enrichment, suggesting a promising new approach for improving breast cancer treatment outcomes.
FRAS1 (Fraser syndrome protein 1), together with FREM1 (the Fras1-related extracellular matrix proteins 1) and FREM2, belonging to the FRAS1/FREM extracellular matrix protein family, are considered to play essential roles in renal organogenesis and cancer progression. However, their roles in kidney renal clear cell carcinoma (KIRC) remain to be elucidated. FRAS1/FREM RNA expression analysis was performed using TCGA/GTEx databases, and valided using GEO databases and real-time PCR.
View Article and Find Full Text PDFRemoving Adversarial Noise via Low-Rank Completion of High-Sensitivity Points.
IEEE Trans Image Process
July 2021
Deep neural networks are fragile under adversarial attacks. In this work, we propose to develop a new defense method based on image restoration to remove adversarial attack noise. Using the gradient information back-propagated over the network to the input image, we identify high-sensitivity keypoints which have significant contributions to the image classification performance.
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