Construction and application of a stratified nursing intervention program for postoperative delirium after Stanford type A aortic dissection: a quasi-experimental trial.

Background: Postoperative delirium is a common and significant consequence in patients with type A aortic dissection following surgery; however, there is currently no effective postoperative care plan.

Objective: The purpose of this study is to develop and evaluate the practical implementation of a stratified nursing intervention program for postoperative delirium in patients undergoing surgery for Stanford type A aortic dissection.

Methods: A stratified nursing intervention program for postoperative delirium was created using a literature review, group discussions, and the Delphi method via expert mail inquiry.

Sensitivity and Specificity of Three Measures of Intrinsic Capacity in Older People Aged 80 and Over in Nursing Homes.

Purpose: Intrinsic capacity (IC), a crucial indicator for the United Nations Decade of Healthy Ageing 2021-2030, is defined by WHO as the foundation of functional ability, representing the composite of all physical and mental capacities of an individual. IC spans five function domains: Locomotor, psychological, cognitive, vitality, and sensory (including vision and hearing). Accurate IC assessment is vital for effective interventions, yet comparative analyses of these tools are scarce.

The Mediating Role of Resilience between Dyadic Perceived Social Support and Depression at the Older Adults with Disabilities and their Family Caregivers in China: An Actor-Partner Interdependence Model Extended to Mediation.

Purpose: The goal of this study is to investigate the actor and partner effects of perceived social support and depression in older adults with disabilities and their family caregivers and to investigate the mediating role of resilience in the actor and cross-partner effects of perceived social support on depression.

Methods: We selected 425 pairs of older adults with disabilities and their family caregiver. We used the Resilience Scale, Perceived Social Support Scale, and Patient Health Questionnaire-9 to evaluate them.

The effect of social isolation on the cognitive ability of the oldest old in Chinese nursing homes in post-COVID-19: a moderated chain mediation model.

Background: Both pre-or post-COVID-19, older adults residing in nursing homes are at significant risk for social isolation, which is negatively associated with cognitive ability. Currently, the elderly aged 80 years and older are the fastest-growing age group globally. The extent of social isolation within this group post-COVID-19 and its impact on cognitive abilities remain inadequately explored.

Intrinsic capacity loss rates and protective factors among individuals aged 80 years and older in Chinese nursing homes: A latent class analysis.

Prior to this cross-sectional study, the intrinsic capacity (IC) loss rates and protective factors in nursing homes for individuals aged 80 and older remained unexplored. Analysing 434 participants, this study found 86.9 % of individuals experienced the loss of at least one IC domain, with detailed losses in locomotion, vision, vitality, hearing, psychological, and cognitive capacities at rates of 83.

Effects of Social Support Provided by Disabled Older Adults to Others on Their Own Depressive Symptoms: A Moderated Mediation Model.

Purpose: While previous studies have extensively examined the impact of receiving positive social support during social support interactions on depressive symptoms among older adults, adverse effects experienced, such as being rejected or ignored, are often overlooked. Moreover, there has been limited discussion on the effects of giving social support to others. Thus, this study investigates the impacts of social support given by disabled older adults to others on their own depressive symptoms, as well as the mediating role of receiving social support (both positive and negative aspects) and the moderating effect of the activity of daily living (ADL).

Development and preliminary validation of a questionnaire on the care needs of family carers of older individuals with disabilities in China: a mixed methods study.

Background: Ensuring the wellness of older individuals with disabilities requires prioritising the care needs of their carers. However, current practice lacks validated tools to measure the needs of carers in home environments. Thus, this study aimed to create and test a questionnaire on the care needs of family carers of older people with disabilities in China.

Cell-type-specific alternative polyadenylation promotes oncogenic gene expression in non-small cell lung cancer progression.

Disrupted alternative polyadenylation (APA) is frequently involved in tumorigenesis and cancer progression by regulating the gene expression of oncogenes and tumor suppressors. However, limited knowledge of tumor-type- and cell-type-specific APA events may lead to novel APA events and their functions being overlooked. Here, we compared APA events across different cell types in non-small cell lung cancer (NSCLC) and normal tissues and identified functionally related APA events in NSCLC.

Quantum-dot light-chip micro-spectrometer.

Micro-spectrometers have great potential in various fields such as medicine, agriculture, and aerospace. In this work, a quantum-dot (QD) light-chip micro-spectrometer is proposed in which QDs emit different wavelengths of light that are combined with a spectral reconstruction (SR) algorithm. The QD array itself can play the roles of both the light source and the wavelength division structure.

Cross-cultural adaptation and validation of the positive and negative social exchange scale in older adults with disabilities in China.

Purpose: This study translated the Positive and Negative Social Exchange (PANSE) scale into Chinese, examined its psychometric characteristics, and explored its feasibility for use among older adults with disabilities from China.

Materials And Methods: A two-stage study procedure was employed. In the first stage, the English version of the PANSE scale was translated and cross-culturally adapted.

At-home disposal practices of used insulin needles among patients with diabetes in China: A single-center, cross-sectional study.

Background: Most insulin injections for people with diabetes are administered at home, thus generating many used needles. Unsafe disposal of these at-home needles can lead to needle stick injuries, blood-borne disease transmission, and environmental contamination. Previous studies have shown varying results on the prevalence of and factors associated with safe sharps disposal practices of people with diabetes.

Fabry-Perot resonance-suppressed double-layer metal mesh window for electromagnetic interference shielding.

Traditional electromagnetic interference shielding windows that can simultaneously reflect microwaves and transmit visible light are usually fabricated by depositing one metal mesh layer on the surface of the window. However, such a structure always suffers from strong Fabry-Perot resonance (FPR), which leads to the decline of shielding effectiveness (SE). Here, we analyze the mechanism of FPR from a perspective of the equivalent circuit model and further report a facile approach to minimize the FPR by depositing another high-resistance mesh layer on the back side of the shielding window, which can greatly reduce reflected waves, ensuring that interference cannot be formed.

Low-cost micro-spectrometer based on a nano-imprint and spectral-feature reconstruction algorithm.

Reconstructive micro-spectrometers have shown great potential in many fields such as medicine, agriculture, and astronomy. However, the performance of these spectrometers is seriously limited by the spectral varieties of response pixels and anti-noise ability of reconstruction algorithms. In this work, we propose a spectral reconstruction (SR) algorithm, whose anti-noise ability is at least four times better than the current algorithms.

Post-discharge care needs of the older people with hospital-associated disability: A longitudinal study.

Aims: To investigate the change and associated factors of care needs within 6 months post-discharge in older people with hospital-associated disability, and the relationship between time-varying care needs and physical function.

Background: Older people with hospital-associated disability will have various care needs post-discharge. Understanding their care needs will help to improve their health.

Effect of self-management and thrombus monitoring on patients with autogenous arteriovenous fistula.

Objective: the objective of this study is to explore the effect of a self-management mode on hemodialysis in autogenous arteriovenous fistula patients, and assess the improvement in their self-care, as well as the management and protection abilities of patients through the self-management mode, so as to improve the quality of dialysis.

Method: A total of 100 patients undergoing maintenance hemodialysis, who have autogenous fistula and were cared for in the First Affiliated Hospital of Wenzhou Medical University from August 2019 to February 2020 were selected. All patients were divided into either an experimental group (group A, 50 people) or a control group (group B, 50 people), at random.

Rehabilitation psychological experience of the elderly within 6 months of initial disability: a qualitative study.

Purpose: To explore the rehabilitation psychological experience of the Chinese elderly within 6 months of initial disability, understand and analyse their real feelings and thoughts to help caregivers in providing support.

Materials And Methods: We adopted the descriptive phenomenology method to purposefully select elderly with initial disability within 6 months from neurorehabilitation departments of 2 hospitals in China, who were able to cooperate with researchers to conduct interviews. The data were collected from semi-structured interviews and analysed using Colaizzi's analysis method.

ADL recovery trajectory after discharge and its predictors among baseline-independent older inpatients.

Background: Among the previous studies about the ADL recovery and its predictors, the researches and resources used to study and protect the baseline-independent older patients from being permanently ADL-dependent was few. We aimed to describe the level of activities of daily living (ADL) at discharge and ADL change within 6 months after discharge in older patients who were ADL-independent before admission but became dependent because of acute illness, and to identify the predictors of early rehabilitation,so as to provide the basis to early intervention.

Methods: Stratified cluster sampling was used to recruit 520 hospitalised older patients who were ADL-independent from departments of internal medicine at two tertiary hospitals from August 2017 to May 2018.

Oncogenic Ras is downregulated by ARHI and induces autophagy by Ras/AKT/mTOR pathway in glioblastoma.

Background: Glioblastoma is a disease with high heterogeneity that has long been difficult for doctors to identify and treat. ARHI is a remarkable tumor suppressor gene in human ovarian cancer and many other cancers. We found over-expression of ARHI can also inhibit cancer cell proliferation, decrease tumorigenicity, and induce autophagic cell death in human glioma and inhibition of the late stage of autophagy can further enhance the antitumor effect of ARHI through inducing apoptosis in vitro or vivo.

Nitazoxanide, an antiprotozoal drug, inhibits late-stage autophagy and promotes ING1-induced cell cycle arrest in glioblastoma.

Glioblastoma is the most common and aggressive primary brain tumor in adults. New drug design and development is still a major challenge for glioma treatment. Increasing evidence has shown that nitazoxanide, an antiprotozoal drug, has a novel antitumor role in various tumors and exhibits multiple molecular functions, especially autophagic regulation.

Oxymatrine induces cell cycle arrest and apoptosis and suppresses the invasion of human glioblastoma cells through the EGFR/PI3K/Akt/mTOR signaling pathway and STAT3.

Oxymatrine (OM), a natural quinolizidine alkaloid extracted from the traditional Chinese herb Sophora flavescens, has been revealed to produce antitumor activities in various cancer cell lines, including glioblastoma lines, in vitro. However, the mechanisms by which OM exerts its antitumor effect against glioma are poorly understood. The aim of this study was to investigate the role of OM in the proliferation, apoptosis and invasion of glioma cells and to reveal the underlying mechanisms.

Prognostic and clinicopathological role of long non-coding RNA taurine upregulated 1 in various human malignancies: A systemic review and meta-analysis.

The aberrant dysregulation of taurine upregulated 1, a novel discovered long non-coding RNA, was ubiquitous in different human solid tumors. Accumulating researches have indicated that taurine upregulated 1 is an independent prognostic indicator in cancer patients. This investigation aimed to further explore the prognostic and clinical significance of taurine upregulated 1 in various types of cancers.

Effect of Positive Psychological Intervention on Well-Being, 2-Week Illness Prevalence, and Salivary Immunoglobulin A.

The study aims to explore the effect of positive psychological intervention (fun activities combined with positive mental health education) on the well-being, 2-week illness prevalence, and salivary immunoglobulin A of empty nesters. Ninety-two empty nesters were divided into intervention ( n = 49) and control ( n = 43) groups. The empty nesters in the intervention group performed the intervention in addition to routine community activities.

Status and determinants of health behavior knowledge among the elderly in China: a community-based cross-sectional study.

Background: Limited studies are available on health behavior knowledge among the elderly and the interaction between the elderly and their children living with them. Using a survey of the elderly in the community and their children living with them, we explored the characteristics that determine health behavior knowledge. We also identified the influencing factors affecting such knowledge.