Publications by authors named "Zhiqin Jia"
Article Synopsis
- Asiaticoside (AS) may help improve conditions related to gestational diabetes mellitus (GDM) by promoting cell proliferation and migration in response to high glucose levels.
- A cell model of GDM was created using HTR-8/Svneo cells, and treatments with AS showed no cytotoxic effects while enhancing key signaling pathway markers (PI3K, AKT2, mTORC1, GLUT4).
- The findings suggest that AS activates the PI3K/AKT pathway, potentially offering a therapeutic strategy for managing GDM.
Triple-negative breast cancer (TNBC) accounts for 10-20% of all human ductal adenocarcinomas and has a poor prognosis relative to other subtypes because of its high propensity to develop metastases. Here, the anticancer effects of asiaticoside (AC) against TNBC and the possible underlying mechanism were examined. We found that AC inhibited the TGF-β1 expression and the SMAD2/3 phosphorylation in TNBC cells, thereby impairing the TGF-β/SMAD signaling.
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