Solution-processed high- photopatternable polymers for low-voltage electronics.

High dielectric constant () polymers have been widely explored for flexible, low-power-consumption electronic devices. In this work, solution-processable high- polymers were designed and synthesized by ultraviolet (UV) triggered crosslinking at a low temperature (60 °C). The highly crosslinked network allows for high resistance to organic solvents and high breakdown strength over 2 MV cm.

Knockdown of AMIGO2 suppresses proliferation and migration through regulating PPAR-γ in bladder cancer.

Purpose: This study aims to reveal the relationship between AMIGO2 and proliferation, migration and tumorigenicity of bladder cancer, and explore the potential molecular mechanisms.

Methods: The expression level of AMIGO2 is measured by qRT-PCR and immunohistochemistry (IHC). Stable AMIGO2 knockdown cell lines T24 and 5637 were established by lentivirus transfection.

Glucose metabolism reprogramming in gynecologic malignant tumors.

The incidence and mortality of gynecological tumors are progressively increasing due to factors such as obesity, viral infection, unhealthy habits, as well as social and economic pressures. Consequently, it has emerged as a significant threat to women's health. Numerous studies have revealed the remarkable metabolic activity of tumor cells in glycolysis and its ability to influence malignant biological behavior through specific mechanisms.

Predictors of Perioperative Complications During Leo Baby Stent Treatment for Acutely Ruptured Intracranial Aneurysms: A Retrospective Multicenter Study.

Background And Objectives: Stent-assisted coiling (SAC) of acutely ruptured aneurysms has been controversial. Moreover, for aneurysms originating from small diameter vessels, the SAC presents more challenges. This study aimed to investigate the predictors of perioperative complications after SAC with Leo baby stent of acutely ruptured aneurysms.

Low temperature multi-catalytic growth and growth mechanism of carbon nanotubes on carbon fiber surfaces.

In order to reduce the etching effect of the catalysts to carbon fibers caused by high temperature during the chemical vapor deposition (CVD) process, four multi-element catalysts, Fe-Co, Fe-Ni, Co-Ni and Fe-Co-Ni, were used to realize the low temperature growth of carbon nanotubes (CNTs) on carbon fibers at 350 °C-400 °C. The results show that the growth state of CNTs has a great relationship with the type of catalysts. The catalytic efficiency of Fe-Co catalysts is low, but the graphitization degree of CNTs is relatively high.

The application of exosomes in the treatment of triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is a heterogeneous and invasive breast cancer (BC) subtype that is estrogen receptor-negative, progesterone receptor-negative, and human epidermal growth factor receptor 2 (Her2)-negative. So far, the treatment of TNBC is still ineffective due to the lack of well-defined molecular targets. Exosomes are nanosized extracellular vesicles composed of lipid bilayers.

A Flexible Circularly Polarized Luminescence Switching Device Based on Proton-Coupled Electron Transfer.

Flexible circularly polarized luminescence (CPL) switching devices have been long-awaited due to their promising potential application in wearable optoelectronic devices. However, on account of the few materials and complicated design of manufacturing systems, how to fabricate a flexible electric-field-driven CPL-switching device is still a serious challenge. Herein, a flexible device with multiple optical switching properties (CPL, circular dichroism (CD), fluorescence, color) is designed and prepared efficiently based on proton-coupled electron transfer (PCET) mechanism by optimizing the chiral structure of switching molecule.

A MOF derived bifunctional electrocatalyst NiZnC-MoC with enhanced performance for overall water splitting.

The efficiency and cost of electrocatalysts are critical factors restricting their application in water electrochemical decomposition. In recent years, transition metal carbides (TMCs) have been highlighted due to their unique characteristics for water splitting: good conductivity and stability. However, their electrochemical performance required further optimization.

Bifunctional catalysts of Ni nanoparticle coupled MoO nanorods for overall water splitting.

The development of active and cost-effective bifunctional catalysts is crucial for water dissociation through electrolysis. In this study, bifunctional catalysts with Ni nanoparticles (NPs) anchored on MoO nanorods have been synthesized dissolution of NiMoO-ZIF under an inert atmosphere without using hydrogen gas. The Ni-MoO catalyst exhibits high electrocatalytic activity by modulating the calcination temperature.

Effect of Microstructures of Carbon Nanoproducts Grown on Carbon Fibers on the Interfacial Properties of Epoxy Composites.

Two kinds of carbon nanoproducts with different microstructures, namely, carbon nanotubes (CNTs) and carbon nanofibers (CNFs), were grown on the surface of carbon fibers (CFs) by chemical vapor deposition (CVD) at low temperatures to improve the interface bonding between fibers and resins. The short-beam method and the micro-debonding method were used to test the interlaminar shear strength (ILSS) and interfacial shear strength (IFSS) of the composites. The results showed that the contribution of CNTs to the improvement of interfacial properties was better than that of CNFs.

Self-aligned stitching growth of centimeter-scale quasi-single-crystalline hexagonal boron nitride monolayers on liquid copper.

Two-dimensional hexagonal boron nitride (hBN) atomic crystals are excellent charge scattering screening interlayers for advanced electronic devices. Although wafer-scale single crystalline hBN monolayer films have been demonstrated on liquid Au and solid Cu (110) and (111) vicinal surfaces, their reproducible growth still remains challenging. Here, we report the facile self-aligned stitching growth of centimeter-scale quasi-single-crystalline hBN monolayer films through synergistic chemical vapor deposition growth kinetics and liquid Cu rheological kinetics control.

A Bioinformatic Analysis of Immune-Related Prognostic Genes in Clear Cell Renal Cell Carcinoma Based on TCGA and GEO Databases.

Background: Clear cell renal cell carcinoma (ccRCC) is a commonly occurring tumor. Through a deeper understanding of the immune regulatory mechanisms in the tumor microenvironment, immunotherapy may serve as a potential treatment for cancer patients. This study aimed at identifying the survival-related immune cells and hub genes, which could be potential targets for immunotherapy in ccRCC.

Wnt2 Contributes to the Development of Atherosclerosis.

Atherosclerosis, is a chronic inflammatory disease, characterized by the narrowing of the arteries resulting from the formation of intimal plaques in the wall of arteries. Yet the molecular mechanisms responsible for maintaining the development and progression of atherosclerotic lesions have not been fully defined. In this study, we show that TGF-β activates the endothelial-to-mesenchymal transition (EndMT) in cultured human aortic endothelial cells (HAECs) and this transition is dependent on the key executor of the Wnt signaling pathway .

Construction of a novel mRNA-signature prediction model for prognosis of bladder cancer based on a statistical analysis.

Background: Bladder cancer (BC) is a common malignancy neoplasm diagnosed in advanced stages in most cases. It is crucial to screen ideal biomarkers and construct a more accurate prognostic model than conventional clinical parameters. The aim of this research was to develop and validate an mRNA-based signature for predicting the prognosis of patients with bladder cancer.

Integrative analysis of immune molecular subtypes and microenvironment characteristics of bladder cancer.

The emergence of immunotherapy has provided an option of treatment methods for bladder cancer (BC). However, the beneficiaries of immunotherapy are still limited to small-scale patients, and immunotherapy-related adverse events often occur. It is a major challenge for clinical work to study the immune subtypes of BC and the molecular mechanism of immune escape, and identify the immune responders accurately.

Analysis on the spatio-temporal characteristics of COVID-19 in mainland China.

COVID-19 has brought many unfavorable effects on humankind and taken away many lives. Only by understanding it more profoundly and comprehensively can it be soundly defeated. This paper is dedicated to studying the spatial-temporal characteristics of the epidemic development at the provincial-level in mainland China and the civic-level in Hubei Province.

Influencing factors and growth kinetics analysis of carbon nanotube growth on the surface of continuous fibers.

Carbon nanotubes (CNTs) were continuously grown on the surface of the moving carbon fiber by chemical vapor deposition method using a custom-designed production line to prepare composite reinforcements on a large-scale. The systematic study of different parameters affecting the CNT growth revealed simple growth kinetics, which helps to control the surface morphology and structural quality of CNTs. Since hydrogen maintains the activity of the catalyst, it promotes the growth of CNTs in a continuous process.

Transcriptomics analysis for the identification of potential age-related genes and cells associated with three major urogenital cancers.

Age is one of the most important risk factors of the occurrence for tumor patients. The majority of patients with urogenital cancers are the elderly, whose clinical characteristics are greatly affected by age and ageing. Our study aimed to explore age-related genes, cells, and biological changes in three common urogenital cancers via integrative bioinformatics analysis.

Subanesthetic isoflurane abates ROS-activated MAPK/NF-κB signaling to repress ischemia-induced microglia inflammation and brain injury.

Isoflurane (ISO) elicits protective effects on ischemia-induced brain injury. We investigated whether sub-anesthetic (0.7%) ISO post-conditioning attenuates the inflammation and apoptosis in oxygen-glucose deprivation (OGD)-insulted co-cultures (microglia and neurons) and the brain injury of the middle cerebral arterial occlusion (MCAO) rat.

Qualitative and Quantitative Wall Enhancement on Magnetic Resonance Imaging Is Associated With Symptoms of Unruptured Intracranial Aneurysms.

Background And Purpose: Aneurysmal wall enhancement (AWE) on vessel wall magnetic resonance imaging (VW-MRI) has been described as a new imaging biomarker of unstable unruptured intracranial aneurysms (UIAs). Previous studies of symptomatic UIAs are limited due to small sample sizes and lack of AWE quantification. Our study aims to investigate whether qualitative and quantitative assessment of AWE can differentiate symptomatic and asymptomatic UIAs.

Graded Channel Junctionless InGaZnO Thin-Film Transistors with Both High Transporting Properties and Good Bias Stress Stability.

InGaZnO (IGZO) is currently the most prominent oxide semiconductor complement to low-temperature polysilicon for thin-film transistor (TFT) applications in flat panel displays. However, the compromised transport performance and bias stress instability are critical issues inhibiting its application in ultrahigh-resolution optoelectronic displays. Here, we report the fabrication of graded channel junctionless IGZO:O|N TFTs with both high transporting properties and good bias stress stability by systematic manipulation of oxygen vacancy (V) defects through sequential O antidoping and O/N codoping of the continuous IGZO framework.

Identification of prognostic biomarkers associated with stromal cell infiltration in muscle-invasive bladder cancer by bioinformatics analyses.

Muscle-invasive bladder cancer (MIBC) is one of the common malignant tumors. Patients with MIBC still have high tumor recurrence and progression rates after surgery. Bioinformatics analysis of stromal infiltration-related genes in the tumor microenvironment (TME) of MIBC patients was performed in this study to determine the major stromal cells types and biomarkers for their progression and poor prognosis.

A Novel Method for Asynchronous Time-of-Arrival-Based Source Localization: Algorithms, Performance and Complexity.

In time-of-arrival (TOA)-based source localization, accurate positioning can be achieved only when the correct signal propagation time between the source and the sensors is obtained. In practice, a clock error usually exists between the nodes causing the source and sensors to often be in an asynchronous state. This leads to the asynchronous source localization problem which is then formulated to a least square problem with nonconvex and nonsmooth objective function.

A Transparent Multidimensional Electrode with Indium Tin Oxide Nanofibers and Gold Nanoparticles for Bistable Electrochromic Devices.

Due to the high energy efficiency and a wide range of potential applications in daily life, bistable electrochromic devices (BECDs) have gained extensive attention in recent years. However, poor bistability and slow response rate are the main barriers, which restrict the development of BECDs. Herein, a transparent multidimensional electrode with indium tin oxide (ITO) nanofibers and gold nanoparticles was fabricated to improve both the bistability and responsiveness of devices.

Long Noncoding RNA PCED1B-AS1 Promotes the Warburg Effect and Tumorigenesis by Upregulating HIF-1α in Glioblastoma.

Accumulating evidence suggests that long noncoding RNA (lncRNA) functions as a critical regulator in cancer biology. Here, we characterized the role of lncRNA PCED1B antisense RNA 1 (PCED1B-AS1) in glioblastoma (GBM). PCED1B-AS1 was notably upregulated in GBM tissues and cell lines and closely associated with larger tumor size and higher grade.