Clock in radiation oncology clinics: cost-free modality to alleviate treatment-related toxicity.

A large number of studies have reported that tumor cells are often out of sync with the surrounding healthy tissue. Exploiting this misalignment may be a way to obtain a substantial gain in the therapeutic window. Specifically, based on reports to date, we will assess whether radiotherapy outcomes differ depending on the administration time.

Geomagnetic Shielding Enhances Radiation Resistance by Promoting DNA Repair Process in Human Bronchial Epithelial Cells.

With the advent of long-duration space explorations, ionizing radiation (IR) may pose a constant threat to astronauts without the protection of Earth's magnetic field, or hypomagnetic field (HMF). However, the potential biological effects of a HMF on the cellular response to IR have not been well characterized so far. In this study, immortalized human bronchial epithelial cells were exposed to X-rays under either a geomagnetic field (GMF, ~50 uT) or HMF (<50 nT) culture condition.

A functional Ser326Cys polymorphism in hOGG1 is associated with noise-induced hearing loss in a Chinese population.

DNA damage to cochlear hair cells caused by 8-oxoguanine (8-oxoG) is essential for the development of noise-induced hearing loss (NIHL). Human 8-oxoG DNA glycosylase1 (hOGG1) is a key enzyme in the base excision repair (BER) pathway that eliminates 8-oxoG. Many epidemiological and functional studies have suggested that the hOGG1 Ser326Cys polymorphism (rs1052133) is associated with many diseases.

A high-impedance attenuator for measurement of high-voltage nanosecond-range pulses.

A novel kind of high-impedance cable attenuator for measurement of high-voltage ns-range pulses is investigated in this paper. The input and output ports of the proposed attenuator were both high-impedance ports, and good pulse response characteristics of the proposed attenuator were obtained with pulse response time less than 1 ns. According to the requirement of measurement, two attenuators with lengths at 14 m and 0.

Coffee consumption and risk of colorectal cancer: a dose-response analysis of observational studies.

Coffee consumption has been linked to risk of colorectal cancer theoretically, but the findings were conflicting from observational studies. Results from the recent meta-analysis suggested a moderate favorable effect of coffee consumption on colorectal cancer risk, especially for colon cancer. However, the relationship, if exists, between coffee consumption and colorectal cancer risk is unclear.

GPX1 gene Pro200Leu polymorphism, erythrocyte GPX activity, and cancer risk.

A meta-analysis was conducted to assess the effect of glutathione peroxidase1 (GPX1) gene Pro200Leu (rs1050450) polymorphism on cancer risk. A comprehensive search was performed to identify all studies on the association of GPX1 gene Pro200Leu polymorphism with cancer risk. The fixed or random effect pooled measure was selected based on homogeneity test among studies.

Dietary calcium intake, vitamin D levels, and breast cancer risk: a dose-response analysis of observational studies.

Results from the recent meta-analysis suggested a favorable effect of dietary calcium and vitamin D levels on breast cancer risk. However, the relationship of dietary calcium and vitamin D levels with breast cancer risk is unclear. Thus, the dose-response relationship was assessed by restricted cubic spline model and multivariate random-effect meta-regression.

Synchronization of high speed framing camera and intense electron-beam accelerator.

A new trigger program is proposed to realize the synchronization of high speed framing camera (HSFC) and intense electron-beam accelerator (IEBA). The trigger program which include light signal acquisition radiated from main switch of IEBA and signal processing circuit could provide a trigger signal with rise time of 17 ns and amplitude of about 5 V. First, the light signal was collected by an avalanche photodiode (APD) module, and the delay time between the output voltage of APD and load voltage of IEBA was tested, it was about 35 ns.

Radial current high power dummy load for characterizing the high power laser triggered transformer-type accelerator.

A radial-current aqueous resistive solution load was applied to characterize a laser triggered transformer-type accelerator. The current direction in the dummy load is radial and is different from the traditional load in the axial. Therefore, this type of dummy load has smaller inductance and fast response characteristic.

[Establishment and application of molecular beacon real-time PCR in the detection of Mycobacteriun tuberculosis].

Objective: To establish a method for detection of M. tuberculosis by molecular beacon real-time PCR and evaluate its application in the clinical detection of M. tuberculosis.