Publications by authors named "Zhiqian Bi"
Owing to the increasing incidence and prevalence of inflammatory bowel disease (IBD) worldwide, effective and safe treatments for IBD are urgently needed. Hydrogen sulfide (HS) is an endogenous gasotransmitter and plays an important role in inflammation. To date, HS-releasing agents are viewed as potential anti-inflammatory drugs.
View Article and Find Full Text PDFhas been widely administrated orally as probiotics to prevent pathogen colonization and modulate the gut microbiome balance. Endostatin is an endogenous inhibitor of angiogenesis and has been shown to inhibit tumor growth, invasion, and metastasis. At present, the combination of endostatin and chemotherapeutic drugs has been regarded as a promising antitumor treatment strategy.
View Article and Find Full Text PDFInflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis, is a complex disease involving genetic, immune, and microbiological factors. A variety of animal models of IBD have been developed to study the pathogenesis of human IBD, but there is no model that can fully represent the complexity of IBD. In this study, we established two acute enteritis models by oral 3% DSS or intraperitoneal injection of anti-CD3 antibody, and two chronic enteritis models by feeding 3 cycles of 1.
View Article and Find Full Text PDFHydrogen sulfide (HS) is widely recognized as the third endogenous gas signaling molecule and may play a key role in cancer biological processes. ADT-OH (5-(4-hydroxyphenyl)-3H-1,2-dithiocyclopentene-3-thione) is one of the most widely used organic donors for the slow release of HS and considered to be a potential anticancer compound. In this study, we investigated the antimetastatic effects of ADT-OH in highly metastatic melanoma cells.
View Article and Find Full Text PDFArticle Synopsis
- * Two fermentation methods were tested: normal oxygen supply and high oxygen supply, which improved cell weight and lipid concentration but decreased the DHA percentage in total fatty acids significantly under high oxygen conditions.
- * Transcriptome analysis revealed that high oxygen conditions led to increased expression of genes related to glycolysis and fatty acid synthesis, suggesting a shift in metabolism that favors lipid accumulation but negatively impacts DHA production.
Article Synopsis
- Lipid production in Schizochytrium sp. can be improved through stress conditions, but such stress typically hampers cell growth and raises oxidative damage, leading to decreased lipid yield.
- To counter this, adaptive laboratory evolution (ALE) was used alongside high salinity to boost the antioxidant system and lipid output, resulting in a new strain (ALE150) after 150 days.
- This strain showed 32.7% higher cell dry weight and 53.31% increased lipid yield, with enhanced antioxidant capacity and lower reactive oxygen species, while transcriptomic analysis revealed upregulation of key genes linked to antioxidant enzymes and lipid metabolism.
Article Synopsis
- The marine microalga sp. shows promise as a sustainable source of DHA-rich lipids, but stress-induced lipid production often leads to lower biomass and lipid instability.
- Adaptive laboratory evolution (ALE) was utilized to enhance the microalga's DHA production and its antioxidant defenses by applying low temperature and high salinity conditions.
- The resulting strain, ALE-TF30, achieved significantly higher cell dry weight and DHA yield while demonstrating reduced lipid peroxidation and increased antioxidant enzyme expression compared to the original strain.