A homologous series of α-glucans from Hemicentrotus pulcherrimus and their immunomodulatory activity.

Seven macromolecular polysaccharides (HPP-2S-HPP-8S) were purified from the gonads of sea urchin Hemicentrotus pulcherrimus. They were characterized as α-glucan homologues, sharing the same α-1,4-glucan backbone substituted at C-6 positions by glucose with HPP-1S that occurs as the major polysaccharide in H. pulcherrimus, while with higher degrees of branching, and additionally possessing minor amounts of mannose and ribose.

Study on pore structure and the mechanical properties of sandstone-concrete binary under freeze-thaw environment.

In China's cold region water conservancy and hydropower projects, the contact interface between the dam and the reservoir bank rock is prone to cracking under external loading and freeze-thaw action, which may lead to dam-bank failure and damage and cause engineering disasters. The NMR (Nuclear Magnetic Resonance) tests and uniaxial compression tests of concrete, sandstone, and sandstone-concrete composite after different numbers of freeze-thaw cycles were carried out to analyze the pore structure development and uniaxial compression mechanical properties of the three types of specimens under different numbers of freeze-thaw cycles. The results show that freeze-thaw cycling promotes the development of pores in sandstone and concrete, and sandstone is more sensitive to low-temperature freeze-thaw than concrete.

Selective Inhibition of PTP1B by New Anthraquinone Glycosides from .

Protein tyrosine phosphatase 1B (PTP1B) is highly validated as a therapeutic target for type 2 diabetes. However, active site-directed PTP1B inhibitors generally suffer from poor selectivity and bioavailability. Inspired by the identification of a unique anthraquinone-coumarin hybrid from exhibiting good specificity for PTP1B over the highly homologous T-cell protein tyrosine phosphatase (TCPTP), further chemical investigation of this plant species led to the isolation of nine new anthraquinone glycosides (-) and two known ones ( and ).

Structure elucidation and antitumor activity of a water soluble polysaccharide from Hemicentrotus pulcherrimus.

Sea urchin nowadays serves as a delicacy around the world, and its gonads accumulate abundant polysaccharides before gametogenesis. However, the structure and bioactivity of these polysaccharides remain less well understood. Herein, a water soluble polysaccharide (HPP-1S) with a molecular weight of 2.