Publications by authors named "Zhinian Wu"
Article Synopsis
- - This study investigates how specific metabolites in patients with liver cirrhosis (LC) can help determine the clinical stage and improve treatment targeting, using advanced mass spectrometry technology.
- - Conducted on 139 patients with LC or acute-on-chronic liver failure (ACLF), researchers analyzed serum samples to find differentially accumulated metabolites (DAMs) associated with cirrhosis progression.
- - Key findings identified six significant DAMs, with certain metabolites peaking at a specific clinical stage before declining, suggesting their potential as biomarkers for assessing the severity of LC and predicting ACLF development.
Article Synopsis
- There's an ongoing discussion about whether FVIII levels or the FVIII/PC ratio can help predict the formation of portal vein thrombosis (PVT) in patients with cirrhosis.
- A meta-analysis included 10 studies with 2,250 cirrhotic patients, revealing no significant difference in FVIII activity levels between those with and without PVT but found significant variability among the studies.
- The analysis showed that while FVIII activity levels weren't a clear predictor, the FVIII/PC ratio was higher in patients with PVT and could be a reliable indicator of PVT risk and liver disease severity.
Background: The complexity of immunoglobulin G4 (IgG4)-related diseases and their potential connection to hematologic malignancies remains unclear. This article provided a review of the diagnosis and treatment of a patient with IgG4-related sclerosing cholangitis (SC) and essential thrombocythemia (ET), along with an analysis of relevant literature to enhance comprehension of this disease.
Case Summary: A 56-year-old male was admitted to two hospitals with deteriorating jaundice and pruritus prior to hospitalization.
Immune-related GTPase M (IRGM) induces autophagy and suppresses inflammation, but its putative role and signaling mechanism remain undefined in the pathogenesis of liver failure. This study aimed to address how IRGM attenuates inflammatory injury by regulating autophagy in liver failure. In this study, a total of 10 patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) and 10 healthy controls were prospectively enrolled.
View Article and Find Full Text PDFRisk factors for short-term prognosis of end-stage liver disease complicated by invasive pulmonary aspergillosis.
Eur J Clin Microbiol Infect Dis
April 2024
Background And Aim: Patients with end-stage liver disease (ESLD) are susceptible to invasive pulmonary aspergillosis (IPA). This study aimed to investigate the risk factors affecting the occurrence and short-term prognosis of ESLD complicated by IPA.
Methods: This retrospective case-control study included 110 patients with ESLD.