Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology, cognition, and behavior in APP/PS1 mice.

JOURNAL/nrgr/04.03/01300535-202502000-00030/figure1/v/2024-05-28T214302Z/r/image-tiff In patients with Alzheimer's disease, gamma-glutamyl transferase 5 (GGT5) expression has been observed to be downregulated in cerebrovascular endothelial cells. However, the functional role of GGT5 in the development of Alzheimer's disease remains unclear.

Ube2c-inhibition alleviated amyloid pathology and memory deficits in APP/PS1 mice model of AD.

Autophagy is a major intracellular degradation pathway for the clearance of damaged organelles and misfolded peptides. Previous studies have indicated that autophagy is involved in the pathogenesis of neurodegenerative disease including Alzheimer's disease (AD). Defective autophagy and highly expressed ubiquitin-conjugating enzyme 2 C (Ube2c) have been found in AD patients and mouse.

The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer's disease.

Neurovascular dysfunction, as an integral part of Alzheimer's disease, may have an important influence on the onset and progression of chronic neurodegenerative processes. The blood-brain barrier (BBB) pathway is one of the main pathways that mediates the clearance of amyloid-beta (Aβ) in the brain parenchyma. A large number of studies have shown that receptors and ATP-binding cassette transporters expressed on endothelial cells play an important role in Aβ transport across the BBB, but the specific mechanism is not clear.

Dynamic event-triggered sliding mode control for interval Type-2 fuzzy systems with fading channels.

This paper addresses the issue of sliding mode control(SMC) for a class of interval type-2(IT2) fuzzy system subject to the fading channel. For relieving the transmission burden, a dynamic event-triggered mechanism is introduced to determine the transmission of the measurement signals via the sensor-to-controller(S/C) channel. In the communication channel, the transmitted signal may suffer from fading in wireless communication networks.

Dynamic Event-Triggered Control for Interval Type-2 Fuzzy Systems Under Fading Channel.

This article is to tackle the event-based state-feedback control problem for interval type-2 (IT2) fuzzy systems subject to the fading channel. For saving communication resources, a dynamic event-triggered (ET) mechanism is utilized to decide the data transmission from sensors to the controller. A time-varying random process is employed to characterize the fading phenomenon in the unpredictable communication network.

Sliding-Mode Control of T-S Fuzzy Systems Under Weighted Try-Once-Discard Protocol.

This article investigates the sliding-mode control (SMC) problem for a class of T-S fuzzy systems with communication constraints. The weighted try-once-discard (WTOD) protocol is utilized to arrange the transmission order of actuator nodes, under which only one node is permitted to obtain access to the communication network at any time. A key issue is how to integrate the WTOD protocol into the design of the SMC system.

Near-infrared emitting iridium(iii) complexes for mitochondrial imaging in living cells.

Biocompatible transition metal complexes dyes emitting in the near-infrared (NIR) region, are highly desirable in fluorescence imaging techniques. However, a high-performance mitochondria-specific labeling NIR probe with high photostability is still lacking. Herein we reported two NIR-emitting cationic iridium(iii) complexes [Ir(pbq-g)(N^N)]Cl (pbq-g = phenylbenzo[g]-quinoline; N^N = 2-(1-benzyl-1H-pyrazol-3-yl) pyridine (Ir1) and 2-(1-(naphthalen-1-ylmethyl)-1H-pyrazol-3-yl) pyridine (Ir2)).