Publications by authors named "Zhiming Gu"

Article Synopsis
  • Myopia rates have surged globally, particularly in East Asia, and research indicates its complex causes, including a potential link to oxidative stress (OS).
  • The study examined the KEAP1-NRF2 signaling pathway and its role in myopia development in form-deprivation myopia guinea pigs, revealing the effect of tert-butylhydroquinone (TBHQ) treatment on slowing myopia progression.
  • Results indicated that TBHQ activates NRF2, promotes KEAP1 degradation, and boosts superoxide dismutase (SOD) levels, enhancing the retinal antioxidant capacity and potentially influencing myopia development.
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Purpose: Myopia has emerged as a significant public health concern. Recent studies have demonstrated that Orthokeratology (Ortho-K) can effectively decelerate axial length (AL) growth, with eyes possessing smaller back optical zone diameters (BOZD) exhibiting greater effectiveness compared to those with larger BOZD. This study aims to analyze the impact of Ortho-K with varying BOZD.

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The primary source of energy losses in distribution networks (DNs) is rooted in line losses, which is crucial to conduct a thorough and reasonable examination of any unusual sources of line losses to guarantee the power supply in a timely and safe manner. In recent studies, identifying and analyzing abnormal line losses in DNs has been a widely and challenging research subject. This article investigates a key technology for the line loss analyses of DNs and intelligent diagnosis of abnormal causes by implementing artificial intelligence (AI), resulting in several prominent results.

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Purpose: To identify the expression of the mechanosensitive ion channel Piezo1 in the retina of guinea pigs with form deprivation myopia (FDM) and to investigate mechanisms by which Piezo1 channels might regulate myopia.

Method: Sixty 3-week-old guinea pigs were divided into four groups randomly: normal control, FDM, FDM + vehicle control (DMSO), and FDM + Piezo1 inhibitor (GsMTx4). Measurements of spherical equivalent (SE) and axial length (AL) of the guinea pig were taken using retinoscopy and A-scan ultrasound examination, respectively.

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Purpose: The retina is a highly energy-consuming tissue associated with visual development, and the reduced quality of retinal imaging can be related to myopia. Synthesis of cytochrome c oxidase 1 () and synthesis of cytochrome c oxidase 2 () are involved in ATP (adenosine triphosphate) synthesis and energy metabolism. This study aimed to observe the morphologic changes and investigate the expression of and induced by form-deprivation myopia (FDM) in the retina and sclera of guinea pigs.

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Background/aim: Acute aortic dissection (AAD) is a rare but fatal disease if left untreated. Symptoms are often similar to common conditions; therefore, the diagnostic strategy is important. We aimed to identify the atypical symptoms in a timely manner without putting patients at greater risk for undetected AAD.

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Microcystins (MCs) are a major group of cyanotoxins with side effects in many organisms; thus, compounds in this group are recognized as potent stressors and health hazards in aquatic ecosystems. In order to assess the toxicity of MCs and detoxification mechanism of freshwater shrimp Macrobrachium nipponense, the full-length cDNAs of the glutathione S-transferase (gst) and catalase (cat) genes were isolated from the hepatopancreas. The transcription level and activity changes in the biotransformation enzyme (glutathione S-transferase (GST)) and antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx)) in the hepatopancreas of M.

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Introduction: We investigated astronaut candidates' physiological and pathological responses to +Gx exposure during simulated emergency return from a running orbit to advance astronaut +Gx tolerance training and medical support in manned spaceflight.

Methods: There were 13 male astronaut candidates who were exposed to a simulated high +Gx acceleration profile in a spacecraft during an emergency return lasting for 230 s. The peak value was 8.

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In this paper, critical global connectivity of mobile ad hoc networks (MANETs) is investigated. We model the two-dimensional plane on which nodes move randomly with a triangular lattice. Demanding the best communication of the network, we account the global connectivity eta as a function of occupancy sigma of sites in the lattice by mobile nodes.

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Objective: To explore the importance and preventive measure of vocal scar after fiber laryngoscope surgery.

Method: The preventive measures such as treatment of the pathogeny, voice exercise, adjustment of operative skill, vocal rest after operation and drug treatment for vocal scars in 350 patients with polyps of vocal cord, vocal nodules and vocal cyst after fiber laryngoscope surgery were adopted in order to reduce the rate of vocal scar. The rate of vocal scar was calculated and analysed to evaluate the effect of preventive measures two month later.

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We propose a model of network growth that generalizes the deactivation model previously suggested for complex networks. Several topological features of this generalized model, such as the degree distribution and clustering coefficient, have been investigated analytically and by simulations. A scaling behavior of clustering coefficient C approximately 1/M is theoretically obtained, where M refers to the number of active nodes in the network.

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Objective: To measure the axial rotation angles of the carpometacarpal joints during the digital opposition of thumb-index finger, thumb-medial finger, thumb-ring finger, thumb-little finger and the thumb's maximal opposition, then the application of these parameters were studied.

Methods: Twenty neutrality-occupation volunteers (female 10, male 10) with no history of hand injuries or related diseases were involved in the study. First, all the markers' 3-D coordinates were obstained using the 3D motion analysis system (EVaRT4.

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A well-known charging process is used to obtain the free energy of an electrical double layer, in which the double layer is built up by a transfer of ions from one phase to another. The present study formulates proofs that this charging process cannot determine the free energy of an electrical double layer.

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Barth syndrome is a genetic disorder that is caused by different mutations in the TAZ gene G4.5. The yeast gene TAZ1 is highly homologous to human TAZ, and the taz1Delta mutant has phospholipid defects similar to those observed in Barth syndrome cells, including aberrant cardiolipin species and decreased cardiolipin levels.

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In eukaryotic cells, the acyl species of the phospholipid cardiolipin (CL) are more highly unsaturated than those of the other membrane phospholipids. Defective acylation of CL with unsaturated fatty acids and decreased total CL are associated with Barth syndrome, an X-linked cardio- and skeletal myopathy attributed to a defect in the gene G4.5 (also known as tafazzin).

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