Achieving 1.7 GPa Considerable Ductility High-Strength Low-Alloy Steel Using Hot-Rolling and Tempering Processes.

To achieve a balanced combination of high strength and high plasticity in high-strength low-alloy (HSLA) steel through a hot-rolling process, post-heat treatment is essential. The effects of post-roll air cooling and oil quenching and subsequent tempering treatment on the microstructure and mechanical properties of HSLA steels were investigated, and the relevant strengthening and toughening mechanisms were analyzed. The microstructure after hot rolling consists of fine martensite and/or bainite with a high density of internal dislocations and lattice defects.

Analysis of the genetic contribution to thoracic aortic aneurysm or dissection in a prospective cohort of patients with familial and sporadic cases in East China.

Background: Thoracic aortic aneurysm or dissections (TAADs) represent a group of life-threatening diseases. Genetic aetiology can affect the age of onset, clinical phenotype, and timing of intervention. We conducted a prospective trial to determine the prevalence of pathogenic variants in TAAD patients and to elucidate the traits related to harbouring the pathogenic variants.

Study on the Minimum Fire-Extinguishing Concentration of Several Commonly Used Extinguishing Agents to Suppress Pyrolysis Gas of Red Pine Wood.

The suppression of forest wood burning has been one of the important research directions in the field of solid combustible fire safety. The process of forest wood flame propagation is a coupled process of solid-phase pyrolysis and gas-phase combustion chemical reactions; therefore, as long as the solid-phase pyrolysis or gas-phase combustion can be suppressed, the forest wood flame propagation can be suppressed and an important contribution can be made to the subsequent suppression of forest wood fires. Previous studies have focused on the inhibition of solid-phase pyrolysis of forest wood, so this paper examines the effectiveness of several common fire suppressants for suppressing forest wood gas-phase flames, starting with the inhibition of forest wood gas-phase combustion.

miR-666-3p Mediates the Protective Effects of Mesenchymal Stem Cell-derived Exosomes Against Oxygen-glucose Deprivation and Reoxygenation- induced Cell Injury in Brain Microvascular Endothelial Cells via Mitogen-activated Protein Kinase Pathway.

Background: Previous studies have reported that mesenchymal stem cell (MSC)- derived exosomes can protect primary rat brain microvascular endothelial cells (BMECs) against oxygen-glucose deprivation and reoxygenation (OGD/R)-induced injury.

Objective: The aim was to identify the key factors mediating the protective effects of MSC-derived exosomes.

Methods: Primary rat BMECs were either pretreated or not pretreated with MSC-derived exosomes before exposure to OGD/R.

A comparative analysis on thermal runaway behavior of Li (NiCoMn) O battery with different nickel contents at cell and module level.

The problem of thermal runaway (TR) propagation challenges the safety design of battery packs, because it aggravates the thermal hazards to accidents. There are many unsolved scientific questions in understanding the mechanisms of TR and its propagation behavior for large format lithium-ion batteries (LIBs). LiNiCoMnO(NCM) is considered as one of the most promising cathode materials for lithium-ion batteries LIBs, given its higher energy design and lower cost.

Mesenchymal Stem Cell-derived Exosomes Rescue Oxygen-Glucose Deprivation-induced Injury in Endothelial Cells.

Objective: The effects of mesenchymal stem cell (MSC)-derived exosomes on brain microvascular endothelial cells under oxygen-glucose deprivation (OGD), which mimic cells in deep hypothermic circulatory arrest (DHCA) in vitro, are yet to be studied.

Methods: MSCs were co-cultured with primary rat brain endothelial cells, which were then exposed to OGD. Cell viability, apoptosis, the inflammatory factors (IL-1β, IL-6, and TNF-α), and the activation of inflammation-associated TLR4-mediated pyroptosis and the NF-κB signaling pathway were determined.

A novel environmental-friendly and safe unpacking powder without magnesium, aluminum and sulphur for fireworks.

A novel environmental-friendly unpacking powder for fireworks which has no sulfur, no magnesium, no aluminum or their alloys has been prepared in this study: potassium perchlorate (75%), potassium hydrogen terephthalate (13%), micronano porous silicon (9%), carbon (2%), ferrocene (1%). The PM2.5 and PM10 were collected by the ambient air particulate sampler, and the gas product was tested with a smoke analyzer and gas chromatograph to investigate its environmental-friendly performance.

3-Nitro-4-(tetrazol-5-yl) furazan: theoretical calculations, synthesis and performance.

The synthesis mechanism of 3-nitro-4-(tetrazol-5-yl)furazan (NTZF) was calculated by Gaussian 09 for the first time, and NTZF was successfully synthesized based on the theoretical design. Its ionic salts (RbNTZF and CsNTZF) were synthesized and studied by single-crystal X-ray diffraction firstly. The thermal stability of NTZF was investigated by TG-DSC and the kinetic data of thermal decomposition were calculated.

Efficacy and safety of Zhibitai in combination with atorvastatin for lipid lowering in patients with coronary heart disease.

Background: Zhibitai, a natural lipid-lowering Chinese medicine, is well tolerated in patients and has low incidence of adverse events. In this study, we evaluated the efficacy, safety, and side effects of Zhibitai in combination with low dose Atorvastatin compared to high dose Atorvastatin in patients with coronary heart disease or at high risk of coronary heart disease.

Methods: This was a randomized, double-blind, multi-center clinical trial on 720 patients with coronary heart disease or at high risk of coronary heart disease.

Dipstick proteinuria is a prognostic indicator of short-term mortality in patients with heart failure.

Background: Proteinuria is common in patients with acute heart failure (AHF). This study investigated the relationship between proteinuria and short-term mortality among patients hospitalized for AHF at two university hospitals.

Methods: Adult hospitalized patients with AHF were retrospectively studied.

Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling.

Ventricular hypertrophy is a powerful and independent predictor of cardiovascular morbid events. The vascular properties of low-dose acetyl salicylic acid (aspirin) provide cardiovascular benefits through the irreversible inhibition of platelet cyclooxygenase 1; however, the possible anti-hypertrophic properties and potential mechanism of aspirin have not been investigated in detail. In this study, healthy wild-type male mice were randomly divided into three groups and subjected to transverse aortic constriction (TAC) or sham operation.

Identification and predicting short-term prognosis of early cardiorenal syndrome type 1: KDIGO is superior to RIFLE or AKIN.

Objective: Acute kidney injury (AKI) in patients hospitalized for acute heart failure (AHF) is usually type 1 of the cardiorenal syndrome (CRS) and has been associated with increased morbidity and mortality. Early recognition of AKI is critical. This study was to determine if the new KDIGO criteria (Kidney Disease: Improving Global Outcomes) for identification and short-term prognosis of early CRS type 1 was superior to the previous RIFLE and AKIN criteria.

Efficacy and safety of low-dose clopidogrel after 12-month dual antiplatelet therapy for patients having drug-eluting stent implantation.

Background: To prevent stent thrombosis (ST) after implantation of drug-eluting stents (DESs) in patients with coronary heart disease, 12-month dual antiplatelet therapy (DAPT) is recommended. However, the optimal long-term antiplatelet regimen is not clear for the patients who have completed the 12-month DAPT.

Methods: We reviewed the data of 755 consecutive patients who had undergone percutaneous coronary intervention (PCI) three years ago and completed 12-month DAPT.

1,5-Diamino-tetra-zolium chloride.

The title compound, CH(5)N(6) (+)·Cl(-), crystallized with two indepedent 1,5-diamino-tetra-zolium cations and two independent chloride anions in the asymmetric unit. In the crystal, there are a number of N-H⋯Cl hydrogen-bonding inter-actions, which generate a three-dimensional network.

Change in high-sensitive C-reactive protein during abdominal aortic aneurysm formation.

Objectives: We try to clear the relationship between high-sensitive C-reactive protein (hsCRP) release and abdominal aortic aneurysm formation.

Methods And Results: A rabbit abdominal aortic aneurysm model was created by elastase perfusion. At days 10, 20, and 30 after elastase perfusion, mean serum hsCRP levels detected by ELISA increased over 200% over their basal level (n = 11, P < 0.

Mechanical strain induces expression of C-reactive protein in human blood vessels.

C-reactive protein (CRP) is a powerful independent risk factor for cardiovascular diseases. Elevated mechanical strain on vessels induces the local expression of proinflammatory cytokines. We hypothesized that mechanical strain on vessels may induce local CRP expression.

N-(1-Diacetyl-amino-1H-tetra-zol-5-yl)acetamide.

In the crystal structure of the title compound, C(7)H(10)N(6)O(3), there are N-H⋯O, N-H⋯N and C-H⋯O inter-actions, generating a three-dimensional supra-molecular network structure. A short intermolecular O⋯C contact of 2.8994 (18) Å is alsopresent in the crystal structure, but no π-π contacts are observed.

1-Isopropyl-ideneamino-1H-tetra-zol-5-amine.

The mol-ecule of the title compound, C(4)H(8)N(6), assumes an approximately planar structure, the methyl C atoms and the C atom to which they are bonded being out of the mean tetrazole ring plane by 0.108 and 0.139, and 0.

N-(5-Amino-1H-tetra-zol-1-yl)formamide.

In the title compound, C(2)H(4)N(6)O, the planar [maximum deviation = 0.006 (2) Å] amino-tetra-zole group makes a dihedral angle of 83.65 (8)° with the formamide unit.

(5Z,7Z)-6,8-Dimethyl-9H-tetra-zolo[1,5-b][1,2,4]triazepine.

The mol-ecule of the title compound, C(6)H(8)N(6), is approximately planar, with a maximum deviation from planarity of 0.099 (1) Å. In the crystal, mol-ecules are linked to each other via pairs of N-H⋯N hydrogen bonding, forming inversion dimers.