PTEN is a key tumor suppressor that regulates essential processes such as cell growth and inflammation by managing the PI3K/AKT signaling pathway, which is vital in rheumatoid arthritis (RA).
Loss of PTEN function can lead to increased survival and pro-inflammatory activity in certain cells, worsening bone damage in RA.
Recent findings suggest that boosting PTEN levels in RA patients could mitigate tissue damage, but more research is needed to fully understand its complex role in RA progression.
* Analyzing data from over 3 million women, the results show significant links between high pre-pregnancy BMI, the occurrence of HDP, and increased PTB risk, with HDP mediating about 63.62% of this relationship.
* The findings suggest that women planning for pregnancy should focus on maintaining a healthy BMI and that pregnant women should monitor for HDP to help lower the risk of PTB.