The serine palmitoyltransferase core subunit StLcb2 regulates sphingolipid metabolism and promotes Setosphaeria turcica pathogenicity by modulating appressorium development.

The fungal pathogen Setosphaeria turcica (S. turcica) causes northern corn leaf blight (NCLB), resulting in significant yield and economic losses in maize. To elucidate the metabolic pathways essential for its pathogenicity, we investigated the metabolome of S.

Identifying substrate triggers for appressorium development in Setosphaeria turcica and functional characterization of Zn(II)2Cys6 transcription factors StTF1 and StTF2.

Northern corn leaf blight is a devastating disease caused by Setosphaeria turcica (S. turcica), leading to significant yield losses in maize. S.

The genome sequencing and comparative genomics analysis of Rhizoctonia solani reveals a novel effector family owning a uinque domain in Basidiomycetes.

Rhizoctonia solani is a soil-borne pathogen with 14 anastomosis groups (AGs), and different subgroups are genetically diverse. However, the genetic factors contributing to the pathogenicity of the fungus have not been well characterized. In this study, the genome of R.

Unveiling the In Situ Evolution of LiO-Rich Solid Electrolyte Interface on CoO Embedded Carbon Fibers as Li Anode Host.

Modification of three-dimensional (3D) carbon hosts with metal oxides has been considered as advantageous for the formation of LiO-rich solid electrolyte interface (SEI), which can show fast Li diffusion, and meanwhile alleviate dendrite problems caused by fragility and nonuniformity of native SEIs. However, the lack of convincing experimental evidence has made it difficult to unveil the true origin of oxygen in LiO-rich SEIs until now. Herein, CoO embedded carbon nanofibers (CNF-CoO) are successfully prepared as high-performance Li anode hosts.

Molecular characterization revealed the role of thaumatin-like proteins of AG4-JY in inducing maize disease resistance.

The gene family of thaumatin-like proteins (TLPs) plays a crucial role in the adaptation of organisms to environmental stresses. In recent years, fungal secreted proteins (SP) with inducing disease resistance activity in plants have emerged as important elicitors in the control of fungal diseases. Identifying SPs with inducing disease resistance activity and studying their mechanisms are crucial for controlling sheath blight.

The catalytic subunit of type 2A protein phosphatase negatively regulates conidiation and melanin biosynthesis in Setosphaeria turcica.

Northern corn leaf blight caused by Setosphaeria turcica is a major fungal disease responsible for significant reductions in maize yield worldwide. Eukaryotic type 2A protein phosphatase (PP2A) influences growth and virulence in a number of pathogenic fungi, but little is known about its roles in S. turcica.

gene is required for filamentous growth, conidial development, and pathogenicity in .

, the fungal pathogen responsible for northern corn leaf blight in maize, forms specialized infectious structures called appressoria that are critical for fungal penetration of maize epidermal cells. The Rab family of proteins play a crucial role in the growth, development, and pathogenesis of many eukaryotic species. Rab4, in particular, is a key regulator of endocytosis and vesicle trafficking, essential for filamentous growth and successful infection by other fungal pathogens.

The Septin Gene Contributes to the Pathogenicity of by Regulating the Morphology, Cell Wall Integrity, and Pathogenic Factor Biosynthesis.

Septins are a conserved group of GTP-binding proteins found in all eukaryotes and are the fourth-most abundant cytoskeletal proteins. Septins of some pathogenic fungi are involved in morphological changes related to infection. Our previous studies have identified four core septins (-) in , the causal agent of northern corn leaf blight, while only is significantly upregulated during the invasive process.

The survival impact of adjuvant radiotherapy and chemotherapy in patients with non-endometrioid endometrial carcinomas: a PSM-IPTW analysis based on SEER database.

Purpose: To investigate outcomes of adjuvant treatments for non-endometrioid endometrial carcinomas (NEEC), as previous studies are limited by its rarity and heterogeneity.

Patients And Methods: Patients with endometrial serous carcinoma (SC), clear cell carcinoma (CCC) and carcinosarcoma were identified between 2004 and 2018 from SEER database. Propensity score matching (PSM) along with inverse probability treatment weighting (IPTW) technique were employed to balance confounding factors.

Survival benefit of surgical treatment for patients with stage IVB endometrial cancer: a propensity score-matched SEER database analysis.

The study aimed to evaluate the value of cancer-directed surgery (CDS) in improving the prognosis of patients with stage IVB endometrial cancer (EC) and under which kind of conditions could maximise its value. The Surveillance, Epidemiology, and End Results database was used to analyse patients diagnosed with stage IVB EC who received chemotherapy between 2004 and 2016. Among 1978 patients were enrolled following propensity score matching (PSM).

Ferroptosis: Mechanism and connections with cutaneous diseases.

Ferroptosis is a recognized novel form of programmed cell death pathway, featuring abnormalities in iron metabolism, SystemXc/glutathione axis, and lipid peroxidation regulation. A variety of ferroptosis inducers can influence glutathione peroxidase directly or indirectly diverse pathways, leading to decreased antioxidant capacity, accumulated cellular lipid peroxides, and finally inducing ferroptosis. To date, mounting studies confirm the association of ferroptosis with various cutaneous diseases, including skin homeostasis, neoplastic diseases, infectious diseases, genetic skin disease, inflammatory skin diseases, and autoimmune diseases.

The impact of omentectomy on cause-specific survival of Stage I-IIIA epithelial ovarian cancer: A PSM-IPTW analysis based on the SEER database.

Objective: Routine omentectomy is generally performed during surgery for patients with epithelial ovarian cancer (EOC). The current study aims to evaluate the impact of omentectomy on cause-specific survival of Stage I-IIIA EOC patients.

Methods: Patients who presented with clinical Stage I-IIIA serous, clear cell, endometrioid, and mucinous ovarian cancers were selected from the SEER Database for the period between 2004 and 2018.

Anaerobic solid-state fermentation with for digesting free gossypol and improving nutritional quality in cottonseed meal.

Microbial fermentation is an effective method to degrade free-gossypol, which is a toxic substance restricting the utilization of cottonseed meal in animal husbandry. However, there are few researches on the nutritional effect and the change of bacterial community on cottonseed meal fermented with anaerobic solid-state fermentation. This study evaluated the effects of fermentation with sp.

Vacuum-Induced Guest ,'-Diethylformamide Binding in a Metastable Cd-Based Metal-Organic Framework.

A three-dimensional (3D) metal-organic framework (MOF) of [EtNH][Cd(BTB)(DEF)]·4.75DEF (; HBTB = benzene-1,3,5-tribenzoic acid and DEF = ,'-diethylformamide) sustained by symmetrical Z-shaped Cd secondary building units (SBUs) with an intrinsically metastable host framework has been prepared and characterized. Upon gentle vacuum (800 Pa) at 50 °C, some encapsulated DEF solvates are released, leading to pore-shape changes and Cd coordination geometry distortion.

Genome Resource of Anastomosis Group 4 Strain AG4-JY, a Pathomycete of Sheath Blight of Foxtail Millet.

The basidiomycetous fungus Kühn (teleomorph [Frank] Donk) is a fungal pathogen that causes various diseases on economically important crops, such as foxtail millet, maize, and rice. Using the PacBio Sequel platform, we assembled a draft genome of an strain AG4-JY that was isolated from foxtail millet with sheath blight at the stem. The genome was approximately 43.

The role of postoperative radiotherapy in patients with uterine sarcomas: A PSM-IPTW analysis based on SEER database.

Objective: The optimal adjuvant therapy for uterine sarcomas remains poorly determined due to its rarity and histological diversity. The purpose of the study is to explore and characterize the association between utilization of radiotherapy and survival outcome in patients with surgically resected uterine sarcomas.

Methods: We collected data regarding uterine sarcomas which were confirmed after total hysterectomy between 2010 and 2018 period from the latest version of the Surveillance, Epidemiology, and End Results (SEER) database.

Protein kinase A participates in hyphal and appressorial development by targeting Efg1-mediated transcription of a Rab GTPase in Setosphaeria turcica.

The cyclic adenosine monophosphate (cAMP) signalling pathway plays an important role in the regulation of the development and pathogenicity of filamentous fungi. cAMP-dependent protein kinase A (PKA) is the conserved element downstream of cAMP, and its diverse mechanisms in multiple filamentous fungi are not well known yet. In the present study, gene knockout mutants of two catalytic subunits of PKA (PKA-C) in Setosphaeria turcica were created to illustrate the regulatory mechanisms of PKA-Cs on the development and pathogenicity of S.

Association between interleukin-17F rs763780 polymorphism and psoriasis risk: A meta-analysis.

Background: The polymorphism of interleukin-17F rs763780 has been found to have a probable association with increased risk of developing psoriasis.

Aims: This study aims to get a more convincing estimation of the association between the interleukin-17F rs763780 T /C polymorphism and psoriasis risk.

Methods: Two authors independently searched the databases including PubMed, EMBASE, Cochrane Central Register of Controlled Trials, Chinese National Knowledge Infrastructure, Wanfang and Chinese Biomedical Literature Databases for case-control studies which reported the odds ratios with 95% confidence intervals comparing genotype and allele frequencies of the interleukin-17F rs763780 polymorphism in patients with psoriasis versus participants without psoriasis.

In Situ Fabrication of Porous Co P Hierarchical Nanostructures on Carbon Fiber Cloth with Exceptional Performance for Sodium Storage.

Superior high-rate performance and ultralong cycling life have been constantly pursued for rechargeable sodium-ion batteries (SIBs). In this work, a facile strategy is employed to successfully synthesize porous Co P hierarchical nanostructures supported on a flexible carbon fiber cloth (Co P@CFC), constructing a robust architecture of ordered nanoarrays. Via such a unique design, porous and bare structures can thoroughly expose the electroactive surfaces to the electrolyte, which is favorable for ultrafast sodium-ion storage.

Novel factors contributing to fungal pathogenicity at early stages of Setosphaeria turcica infection.

The fungal pathogen Setosphaeria turcica causes leaf blight on maize, which leads to considerable crop losses. However, how S. turcica establishes sustained systemic infection is largely unknown.

Highly Active PdO/Mn O /CeO Nanocomposites Supported on One Dimensional Halloysite Nanotubes for Photoassisted Thermal Catalytic Methane Combustion.

In this work, we have successfully triggered the aqueous auto-redox reactions between reductive Ce(OH) and oxidative MnO /Pd ions to form PdO/Mn O /CeO (PMC) nanocomposites. PMC could spontaneously self-assemble into compact encapsulation on the surface of halloysite nanotubes (HNTs) to form the final one dimensional HNTs supported PMCs (HPMC). It is identified that there exists strong synergistic effects among the components of PdO, Mn O , and CeO , and hence HPMC could show excellent performance on photoassisted thermal catalytic CH combustion that its light-off temperature was sharply reduced to be 180 °C under visible light irradiation.

The diagnostic significance of PGGT1B in psoriasis.

Psoriasis is a chronic and recurrent inflammatory skin disorder driven by a complex cascade of inflammatory mediators. The present study focused on the potential clinical significance of PGGT1B in psoriasis development. The peripheral blood mononuclear cells (PBMCs) were isolated from 81 psoriasis patients and 84 healthy controls, and the expression levels of PGGT1B in PBMCs were examined by quantitative real-time polymerase chain reaction (RT-qPCR) methods.