Bacterial Cytochrome P450 Catalyzed Post-translational Macrocyclization of Ribosomal Peptides.

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a fascinating group of natural products that exhibit diverse structural features and bioactivities. P450-catalyzed RiPPs stand out as a unique but underexplored family. Herein, we introduce a rule-based genome mining strategy that harnesses the intrinsic biosynthetic principles of RiPPs, including the co-occurrence and co-conservation of precursors and P450s and interactions between them, successfully facilitating the identification of diverse P450-catalyzed RiPPs.

sp. nov., a symbiotic bacterium isolated from a marine invertebrate.

A novel symbiotic bacterium, designated strain XY-114, was isolated from the cerata of an marine invertebrate species collected in the South China Sea. Strain XY-114 was an aerobic, Gram-stain-negative, non-motile and short rod-shaped bacterium (0.5-0.

Anthraquinones as Potential Antibiofilm Agents Against Methicillin-Resistant .

Biofilms formed by methicillin-resistant (MRSA) are one of the contributing factors to recurrent nosocomial infection in humans. There is currently no specific treatment targeting on biofilms in clinical trials approved by FDA, and antibiotics remain the primary therapeutic strategy. In this study, two anthraquinone compounds isolated from a rare actinobacterial strain R62, 3,8-dihydroxy-l-methylanthraquinon-2-carboxylic acid () and 3,6,8-trihydroxy-1-methylanthraquinone-2-carboxylic acid (), together with their 10 commercial analogs - were evaluated for antibacterial and antibiofilm activities against MRSA, which led to the discovery of two potential antibiofilm anthraquinone compounds anthraquinone-2-carboxlic acid () and rhein ().

sp. nov., isolated from a marine invertebrate from South China Sea, and transfers of , and to comb. nov., nom. nov. and nom. nov., respectively, and emended description of the genus .

An aerobic, Gram-stain-negative, rod-shaped and non-motile strain (XY-359) was isolated from the mouth of a marine invertebrate species from the South China Sea. It grew at pH 6.0-8.

Maipomycin A, a Novel Natural Compound With Promising Anti-biofilm Activity Against Gram-Negative Pathogenic Bacteria.

Pathogenic bacterial biofilms play an important role in recurrent nosocomial and medical device-related infections. Once occurred, the complex structure of the biofilm promotes the development of antibiotic resistance and becomes extremely difficult to eradicate. Here we describe a novel and effective anti-biofilm compound maipomycin A (MaiA), which was isolated from the metabolites of a rare actinomycete strain XY-R10.

sp. nov., isolated from mangrove rhizosphere soil.

Strain XY-J91, a Gram-stain-negative, reddish orange, non-spore-forming and short-rod-shaped marine bacterium, was isolated from rhizosphere soil of the mangrove plant (L.) Druce in Mai Po Nature Reserve, Hong Kong. The strain showed growth at 15-50 °C (optimum 40 °C), at pH 5.

sp. nov., isolated from a marine invertebrate from the South China Sea.

A novel bacterial strain, XY-99, was isolated from the epidermis of a marine invertebrate of the genus from seawater of the South China Sea. The cells of the strain were aerobic, Gram-stain-negative, non-motile, and oval-shaped (0.8-1.

Euzebya rosea sp. nov., a rare actinobacterium isolated from the East China Sea and analysis of two genome sequences in the genus Euzebya.

Rare Actinobacteria, known as non-Streptomyces, hold great potential to produce new bioactive compounds for drug development. A strain designated DSW09, which belongs those rare Actinobacteria, was isolated from surface seawater of the East China Sea. The cells were aerobic, Gram-positive, non-motile, non-spore-forming and rod-shaped (0.

Kandeliimicrobium roseum gen. nov., sp. nov., a new member of the family Rhodobacteraceae isolated from mangrove rhizosphere soil.

A Gram-stain-negative, non-flagellated, short rod-shaped bacterium, designated XY-R6, was isolated from the rhizosphere soil of a mangrove plant, Kandelia candel (L.) Druce, in Mai Po Nature Reserve, Hong Kong. Growth of strain XY-R6 was observed at pH 5.