Nicorandil-based hydrogel promotes bone defect reconstruction by targeting Hmox1.

Background: The local use of drugs to promote bone healing is still difficult to apply clinically. We aimed to construct a nicorandil-based hydrogel to promote local bone healing by promoting angiogenesis and inhibiting osteoclastogenesis.

Results: In this study, we constructed a nicorandil-based hydrogel and used it to intervene in bone repair during bone defect reconstruction.