[Construction and validation of a predictive model for early occurrence of lower extremity deep venous thrombosis in ICU patients with sepsis].

Objective: To investigate the risk factors of lower extremity deep venous thrombosis (LEDVT) in patients with sepsis during hospitalization in intensive care unit (ICU), and to construct a nomogram prediction model of LEDVT in sepsis patients in the ICU based on the critical care scores combined with inflammatory markers, and to validate its effectiveness in early prediction.

Methods: 726 sepsis patients admitted to the ICU of the Affiliated Hospital of Jining Medical University from January 2015 to December 2021 were retrospectively included as the training set to construct the prediction model. In addition, 213 sepsis patients admitted to the ICU of the Affiliated Hospital of Jining Medical University from January 2022 to June 2023 were retrospectively included as the validation set to verify the performance of the prediction model.

Clinical significance of miRNA-195 expression in patients with laryngeal carcinoma.

Purpose: This study aimed to investigate the expression pattern of microRNA (miRNA)-195 in laryngeal carcinoma and analyze the relationships of miRNA-195 expression with clinicopathological features and prognosis.

Methods: The expression levels of miRNA-195 in pathological cancer tissue and tumor-adjacent normal tissue of 182 patients with laryngeal carcinoma were measured by reverse transcription-polymerase chain reaction (RT-PCR), and the relationships of relative expression levels of miRNA-195 with clinicopathological features and prognosis of patients with laryngeal carcinoma were analyzed. The invasive ability of cells was measured by Transwell chamber test.

Induction of apoptosis in hepatocellular carcinoma Smmc-7721 cells by vitamin K(2) is associated with p53 and independent of the intrinsic apoptotic pathway.

Vitamin K(2) (VK(2)) can exert cell growth inhibitory effects in various human cancer cells. In this study, we investigated the cell growth inhibitory effects of VK(2) in hepatocellular carcinoma Smmc-7721 cells and the mechanisms involved. We found that VK(2)-inhibited cell proliferation in Smmc-7721 cells in a dose-dependent manner, and the IC50 of VK(2) in Smmc-7721 cells was 9.