[Life expectancy of patients with primary glaucoma, residents of a large industrial city of Siberia].

Purpose: To investigate life expectancy and the structure of causes of death in patients with primary glaucoma, residents of a large industrial city of Siberia.

Material And Methods: The database of the Novokuznetsk Public Health Department information analysis center on registration forms 025 (outpatients) and 066 (inpatients) for 2004-2011 was analyzed.

Results: A total of 5424 primary glaucoma patients were registered during 2004-2011, of whom 441 (8.

[The influence of depression on the aggregate state of blood in elderly patients with cardiovascular diseases].

The work is dedicated to the effects of the psychoemotional status of patients older than 65 suffering from coronary artery disease (CAD) and arterial hypertension (AH) on the aggregative status of blood. Sixty-eight patients with mild stable stenocardia accompanied by AH and comorbid depression (CD) were examined; 28 elderly patients with CAD, AH, and no CD constituted the comparison group. The study found that CD in elderly patients with stable stenocardia did not only lower the quality of life, but also worsened hemodynamic parameters.

[Development of microencapsulating measles live vaccine].

Designing of non-injection methods of immunization against measles has recently turned into a topical issue. Development of mucosal vaccines ensuring the "entry gate" immunity, which is highly effective in airborne infection, is in the focus of attention. The authors developed a method of microencapsulating the viral particles into the matrix of pH-dependent polymers.

[Specific epidemiologic features of Crimean haemorrhagic fever in Stavropol' region in 1999-2000].

The results of the epidemiological analysis of morbidity in Crimean haemorrhagic fever in the Stavropol Territory in 1999-2000 are presented. The epidemiological features, specifically characteristic of the manifestations of this infection in the territory, have been determined.

[Elaboration of live measles vaccine technology on human embryo lung diploid cell culture L-68].

Measles predominates among childhood droplet infections in many countries. Immunization of all human beings sensitive to this infection is the only radical measure in controlling measles. The quality of a vaccine is primarily determined by the properties of the virus strains and cell cultures and technology of production.

[Hospital infection morbidity in the Russian Federation].

The epidemiological analysis of hospital infection morbidity in Russia at the period of 1990-1991 made it possible to establish the occurrence of hospital infections among hospitalized patients throughout the country. The data on the structure of registered hospital infections were obtained. These data indicate that the prevalent part of hospital infections were neonatal purulent septic infections and postoperative infections; among the former, ophthalmic infections and infections of the skin and subcutaneous fat prevailed.

[Lymphocyte subpopulations in patients with viral hepatitis B and delta-infections].

Changes in subpopulations of T3, T4, T8, HNK-1, Ia-positive, B-IgM and B-IgG producing lymphocytes were studied in patients with acute and chronic active virus hepatitis B and delta infection. A decrease of T4-helpers/inducers was demonstrated in all the groups under study and of T3-lymphocytes only in patients with delta-hepatitis turning into liver cirrhosis. The number of suppressors/cytotoxic T8 cells increased and T4/T8 ratio decreased in most patients.

[Lymphocyte subpopulations in carriers of antibodies to the human immunodeficiency virus].

Changes in subpopulations of OKT 3, OKT 4, OKT 8, HNK-I, B-IgM, and B-IgG-producing lymphocytes in carriers of HIV antibodies were studied. A decrease in OKT 4 helpers/inducers, an increase in OKT 8-suppressors of cytotoxic cells, HNK-I, Ia-positive and B-IgM-producing lymphocytes was demonstrated. The ratio of OKT 4/OKT 8 lymphocytes was below 1.

[The immune status in variants of the course and outcome of acute delta virus infection].

The immune status was investigated in 32 patients with acute hepatitis of mixed etiology and in 39 HBsAg carriers, superinfected with delta virus. The relationship of changes in the immune status with a course and outcomes of acute delta virus infection was revealed. These changes returned to normal on patients with a cyclic course of disease, persisted in patients with a lingering process, and progressed in the development of subacute liver dystrophy.

[Further study of viral non-A, non-B hepatitis].

The paper describes the study of non-A-non-B virus hepatitis with parenteral mechanism of the infection transmission. Immunofluorescence method was used to test 9 liver biopsies from patients with non-A-non-B hepatitis using blood sera from convalescents after this disease. In 6 liver preparations, diffuse fluorescence of hepatocyte cytoplasm was observed.

[Detection of inapparent forms of hepatitis in foci of the infection by using sensitive methods of specific diagnosis].

The use of specific sensitive methods for demonstration of hepatitis A markers has made it possible to detect 6 children with inapparent form of the disease among 86 subjects present in the focus of infection. Specific HAV antibody of the M class were detected in 100% of them. By radioimmunoassay, hepatitis A virus antigen (HAV-Ag) was detected in fecal extracts in 1 case only.

[Viral hepatitis A and B in anthropoid apes of the Moscow Zoo].

The rate of occurrence of hepatitis A and B virus specific markers in anthropoid apes of the Moscow Zoo (3 chimpanzees, 3 gorillas, 8 orang-outangs) was studied. Long-term persistence of HBs-antigen in orang-outang accompanied by the presence of HBe-antigen and anti-HBs was demonstrated. The presence of anti-HBs in gorillas and orang-outangs was recorded.

[HBcAg antibodies in acute viral hepatitis B in adults and infants in the 1st year of life].

The study was carried out with blood sera from 122 patients with viral hepatitis B (94 adults and 28 infants). The specific markers of hepatitis B virus (HBsAg, anti-HBs, anti-HBc) were tested in the time course of the disease at 10-day intervals in the acute period and for a year after the discharge. Radioimmunoassay (RIA) revealed anti-HBc in the blood of adults and infants suffering from hepatitis B both in the presence and absence of HBsAg.

[Markers of hepatitis-viral infection in children born of mothers with hepatitis B].

Sixty-two women suffering from hepatitis B (HB) and their newborn babies were examined by a highly sensitive radioimmunoassay (RIA). The fluorescent antibody technique was also used to examine autopsy specimens of livers of 7 fetuses, 1 stillborn, and 3 babies dying in the first days of life whose mothers during pregnancy or delivery had experienced HB. Frequent infection of babies (77.

[Hepatitis B virus antigens and antibodies in acute infection].

Investigations of hepatitis B virus antigens (HBsAg and HBeAg) and antibody (anti-HBc, anti-HBe, anti-HBs) and DNA-polymerase activity in 136 patients with acute virus hepatitis B revealed their different diagnostic value depending on the severity of the process. The rate of finding of hepatitis B virus antigens declines in regression of the clinical symptoms of the disease. However, when hepatodystrophy develops, HBsAg and HBeAg concentration decreases, anti-HBc persist, and in one third of the patients anti-HBs are found.

[Immunofluorescence method of determining HBc-antibodies in the blood sera of serum hepatitis type B patients].

The indirect immunofluorescent procedure was used to examine blood sera from 68 patients with serum hepatitis having HBsAg. HBcAb were found in 85% of the specimens. Formalin-fixed paraffin sections of autopsy livers pretreated with enzyme and containing HBcAg in hepatocyte nuclei were shown to be a useful tissue substrate.

[Use of peroxidase and FITC labeled antibodies for express-diagnosis of influenza].

The evaluation of influenza antigen detection was done in comparative experiments on the same material during an epidemic of influenza due to A2/Victoria (H3N2) influenza virus. Cells of the nasal mucosa from 65 patients were tested at the same intervals by two methods showing no difference in the principle of the reaction: peroxidase-labeled (IP) and FITC-labeled (IF) antibody. By the latter method influenza could be diagnosed in 36% of cases, by IP in 38%, by the combination of the two in 56%.

[Herpes simplex in acute viral respiratory diseases].

Herpes in main viral acute respiratory diseases (ARD) in adults (influenza, parainfluenza, adenovirus and mixed infections) was studied by different laboratory methods of diagnosis. It was found that in 44.5% viral ARD were accompanied by herpes in the clinically overt or latent form.

[Virological and serological examination of wild birds during the spring migrations in the region of the Manych Reservoir, Rostov Province].

In accordance with the Soviet-American collaboration program on influenza and ARD, cooperative field studies were undertaken in 1975 in the USSR in order to test the field and laboratory methods for studies on influenza virus ecology. In the Rostov region of the USSR, virological and serological examinations of 321 birds of 25 species were carried out. Virological tests were performed with 678 biological specimens and in various serological tests 308 blood serum specimesn from wild birds were examined.