Omics Insights into Metabolic Stress and Resilience of Rats in Response to Short-term Fructose Overfeeding.

Scope: Considerable evidence supports the view that high-fructose intake is associated with increased and early incidence of obesity and dyslipidemia. However, knowledge on physiopathological alterations introduced by fructose overconsumption is lacking. Therefore, an integrated omics analysis is carried out to investigate the consequences of short-term fructose overfeeding (SFO) and identify the underlying molecular mechanisms.

Evaluation of the estimated variables for scaling glomerular filtration rate of renal patients: a repeated measures-based method.

Objective: Using a best variable to scale glomerular filtration rate (GFR) is important for clinical practice. The variables, estimated by equations regressed from a healthy population, are usually used in scaling GFR of renal patients. However, because the predicted variables may deviate in renal patients, it is necessary to verify whether these variables can be used to reduce the variability of GFR of renal patients.

Evaluation of body surface area formulae for scaling GFR of adult renal patients: more between-subject variability explained by the DuBois & DuBois formula.

Background: Scaling glomerular filtration rate (GFR) to body surface area (BSA) has been widely accepted, and was debated in recent years. Although the indexation ability of BSA is inferior to other physiological variables, the evaluation of BSA formulae is still meaningful to clinical practice. In this study, to evaluate the indexation ability of BSA formulae, the repeated measures analyses of camera-based scintigraphy (Gates method, gGFR) and plasma-based clearance (pGFR) were used to specially focus on the between-subject variability that tried to be minimized by GFR normalization.

Surgical trauma induces iron accumulation and oxidative stress in a rodent model of postoperative cognitive dysfunction.

Postoperative cognitive dysfunction (POCD) is recognized as a complication after surgery in the elderly. The exact pathogenic mechanisms of POCD are still unknown. In this study, we investigated the role of iron accumulation within the central nervous system in the development of cognitive dysfunction in rats following splenectomy.

Lean body mass is better than body surface area in correcting GFR.

Purpose: The Gates-based renography (gGFR) and plasma-based clearance rate (pGFR) are conventionally corrected with body surface area (BSA). Limited studies indicated that the lean body mass (LBM) might be better than BSA in correcting pGFR. Therefore, we suggest that LBM is also better in correcting gGFR and improve the correlation coefficient between gGFR and pGFR.

[Radioiodine-131 therapy improves sex hormones and sexual function in male patients with Graves' disease].

Objective: To observe the changes of sex hormones and sexual function in male patients with Graves' disease (GD) after Radioiodine-131 (I-131) therapy.

Methods: Thirty-four male GD patients, aged 21 -40 (32.3 +/- 6.