Multi-wavelength emission nitrogen-doped carbon dots as fluorescent nanosensing platform for the detection of ascorbic acid and their application in bioimaging tracking.

Vitamins are indispensable active components of the human body, and their abnormal levels are often closely related to various diseases. Therefore, searching for ultra-sensitive and accurate vitamin detection strategies is essential and significant for clinical examination and diagnosis. In this paper, multi-wavelength emission fluorescent nitrogen-doped carbon dots (N-doped CDs) were synthesized by a one-step solvothermal method using four-leaf green fluorescent extract, O-phenylenediamine, and β-cyclodextrin as the raw materials, and N, N-dimethylformamide as the solvent.

Facile Synthesis of MoP and Its Composite Structure with Ru as an Efficient Electrocatalyst for Hydrogen Evolution Reaction in Both Acidic and Alkaline Conditions.

Developing low-cost electrocatalysts for efficient hydrogen evolution in both acidic and alkaline conditions is crucial for water-electrolytic hydrogen applications. Herein, MoP was synthesized via a simple, low-cost, and green phosphorization route. More importantly, the Ru/MoP composite prepared using the as-synthesized MoP as a reactant, which exhibited excellent catalytic activity for the hydrogen evolution reaction.

Injectable Therapeutic Hydrogel with HO Self-Supplying and GSH Consumption for Synergistic Chemodynamic/Low-Temperature Photothermal Inhibition of Postoperative Tumor Recurrence and Wound Infection.

Postoperative tumor recurrence and wound infection remain significant clinical challenges in surgery, often requiring adjuvant therapies. The combination treatment of photothermal therapy (PTT) and chemodynamic therapy (CDT) has proven to be effective in cancer treatment and wound infection. However, the hyperthermia during PTT increases the risk of normal tissue damage, severely impeding its application.

Exposure of particulate matter (PM) induces neurodevelopmental toxicity in zebrafish embryos.

Particulate matter with 10 μm or less in diameter (PM) exposure is a major threat to health and environment around the world. Even though a number of clinical and experimental studies have focused on the cardiopulmonary effects of PM, its impact on neurovascular development and the underlying toxicity is relatively less studied. The present study is therefore undertaken to evaluate the potential toxic effects of PM on neurodevelopment and the associated gene expression profiles in the zebrafish embryo/larvae.

Isoniazid promotes the anti-inflammatory response in zebrafish associated with regulation of the PPARγ/NF-κB/AP-1 pathway.

Objective: Zebrafish inflammation models were used to evaluate the anti-inflammatory activity of isoniazid (INH) and preliminarily investigate the underlying mechanism.

Methods: Local, acute, and systemic zebrafish inflammation models were established by tail cutting, copper sulfate (CuSO), and lipopolysaccharide (LPS) endotoxin treatments, respectively, to evaluate the anti-inflammatory activity of INH. Zebrafish in the inflammatory state were exposed to different concentrations of INH (1, 2, and 4 mM) for 72 h to observe changes in the migration and accumulation of inflammatory cells and measure the reactive oxygen species (ROS) content in zebrafish after INH treatment.

Discovery of nitrogenous sesquiterpene quinone derivatives from sponge Dysidea septosa with anti-inflammatory activity in vivo zebrafish model.

Two unique nitrogenous sesquiterpene quinone meroterpenoids, dysidinoid B (1) and dysicigyhone A (2), together with eight known analogues (3-10) were isolated and characterized from the marine sponge Dysidea septosa. Their structures with absolute configurations were established by a combination of extensive spectroscopic, electron circular dichroism (ECD) and single-crystal X-ray diffraction data analysis. Structurally, dysicigyhone A (2) possessed a unique benzo[d]oxazolidine-2-one unit.

Charge-Transfer-Induced Photoluminescence Properties of WSe Monolayer-Bilayer Homojunction.

The charge-transfer process in transition-metal dichalcogenides (TMDCs) lateral homojunction affects the electron-hole recombination process of in optoelectronic devices. However, the optical properties of the homojunction reflecting the charge-transfer process has not been observed and studied. In this work, we investigated the charge-transfer-induced emission properties based on monolayer (1L)-bilayer (2L) WSe lateral homojunction with dozens of nanometer monolayer region.

Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: Activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway.

Isoniazid (INH) is a first-line anti-tuberculosis drug. INH has been detected in surface waters which may create a risk to aquatic organisms. In this study, the hepatotoxicity of INH was elucidated using zebrafish.

Hepatotoxicity Induced by Isoniazid-Lipopolysaccharide through Endoplasmic Reticulum Stress, Autophagy, and Apoptosis Pathways in Zebrafish.

Isoniazid (INH) is a first-line antituberculosis drug. The incidence of adverse reactions accompanied by inflammation in the liver during drug administration to tuberculosis patients is high and severely affects clinical treatment. To better understand the mechanism of hepatotoxicity induced by INH under the inflammatory state, we compared the differences in levels of hepatotoxicity from INH between normal zebrafish and zebrafish in an inflammatory state to elucidate the hepatotoxic mechanism using different endpoints such as mortality, malformation, inflammatory effects, liver morphology, histological changes, transaminase analysis, and expression levels of certain genes.

Direction-resolved radiation from polarization-controlled surface plasmon modes on silver nanowire antennas.

Metallic nanowires (NWs) support multiple surface plasmon (SP) modes, which lead to extraordinary SP propagation behaviors. The leaky SP modes in metallic NWs connect the guiding and radiation of light at the nanometer scale. Understanding and controlling these modes are of vital importance for various nanophotonic applications.

Directionally-controlled periodic collimated beams of surface plasmon polaritons on metal film in Ag nanowire/Al2O3/Ag film composite structure.

Plasmonics holds promise for the realization of miniaturized photonic devices and circuits in which light can be confined and controlled at the nanoscale using surface plasmon polaritons (SPPs), surface waves of collective oscillations of electrons at a metal/dielectric interface. However, realizing plasmonic applications fundamentally requires the ability to guide and transfer SPPs in different plasmonic structures. Here the generation and control of periodic collimated SPP-beams are reported in composite structures of silver nanowire on silver film with a dielectric spacer layer between them.