Discovery of Novel (5-Mercapto-4-phenyl-4-1,2,4-triazol-3-yl)methyl Phenyl Carbamate as a Potent Phytoene Desaturase Inhibitor through Scaffold Hopping and Linker Modification.

Phytoene desaturase (PDS) is a key rate-limiting enzyme in the carotenoid biosynthesis pathway. Although commercial PDS inhibitors have been developed for decades, it remains necessary to develop novel PDS inhibitors with higher bioactivity. In this work, we used the scaffold hopping and linker modification approaches to design and synthesize a series of compounds (-, -, and -).

Urban flood-bearing vulnerability evaluation based on the moment estimate weighting and improved gray target model.

Increasingly severe flooding seriously threatens urban safety. A scientific urban flood-bearing vulnerability assessment model is significant to improve urban risk management capacity. The gray target model (GTM) has advantages in urban flood-bearing vulnerability assessment.

Discovery of (5-(Benzylthio)-4-(3-(trifluoromethyl)phenyl)-4-1,2,4-triazol-3-yl) Methanols as Potent Phytoene Desaturase Inhibitors through Virtual Screening and Structure Optimization.

Phytoene desaturase (PDS) is not only an important enzyme in the biosynthesis of carotenoids but also a promising target for herbicide discovery. However, in recent years, no expected PDS inhibitors with new scaffolds have been reported. Hence, a solution for developing PDS inhibitors is to search for new compounds with novel chemotypes based on the PDS protein structure.

Association of Variants with Reduced Kidney Function in Patients with Diabetic Kidney Disease.

Diabetic kidney disease (DKD) is the leading cause of morbidity and mortality in patients with diabetes mellitus (DM) and the most common variant of end-stage renal disease (ESRD) globally. The economic burden of ESRD treatment with dialysis is substantial. The incidence and prevalence of ESRD in Taiwan remain the highest worldwide.

Gender Differences in Genetic Associations of RAB38 with Urinary Protein-to-Creatinine Ratio (UPCR) Levels in Diabetic Nephropathy Patients.

Renal dysfunction is common in patients with diabetes mellitus (DM). Previous findings from a meta-analysis of GWAS indicated that the variation of is highly associated with the urinary albumin-to-creatinine ratio (UACR) in European populations. In addition, knockout rats showed an increase in urinary albumins.

Anthropogenic Effects on Hydrogen and Oxygen Isotopes of River Water in Cities.

Stable hydrogen and oxygen isotopes are important indicators for studying water cycles. The isotopes are not only affected by climate, but are also disturbed by human activities. Urban construction has changed the natural attributes and underlying surface characteristics of river basins, thus affecting the isotopic composition of river water.

Bioelectricity generation from air-cathode microbial fuel cell connected to constructed wetland.

The aim of this study was to investigate the different performance of bioelectricity generation and wastewater treatment between constructed wetland (CW) respectively coupled with air-cathode microbial fuel cell (ACMFC) and microbial fuel cell (MFC) under a fed-batch mode. During a 75-day-operation, the voltage of CW-ACMFC and CW-MFC ranged from 0.36 to 0.

The Impact on the Ecosystem Services Value of the Ecological Shelter Zone Reconstruction in the Upper Reaches Basin of the Yangtze River in China.

With regional socio-economic development and increasing population, the structure and function of terrestrial ecosystem environments on the earth's surface have changed markedly. Ecological shelter zone reconstruction () is an ecosystem restoration and conservation project, which aims to ensure the safety of the ecological environments of-regions and basins. We selected the upper reaches of the Yangtze River (from Yibin to Chongqing) as the study area and determined the connotation of .

Bioelectricity generation, contaminant removal and bacterial community distribution as affected by substrate material size and aquatic macrophyte in constructed wetland-microbial fuel cell.

Integrating microbial fuel cell with constructed wetland (CW-MFC) is a novel way to harvest bioelectricity during wastewater treatment. In this study, the bioelectricity generation, containment removal and microbial community distribution in CW-MFC as affected by substrate material sizes and aquatic macrophyte were investigated. The planted CW-MFC with larger filler size showed a significant promotion of the relative abundance of electrochemically active bacteria (beta-Proteobacteria), which might result in the increase of bioelectricity generation in CW-MFC (8.