Terpenoid mosquito repellents: a combined DFT and QSAR study.

Interactions between low-toxicity terpenoid mosquito repellents and lactic acid are studied at the HF and B3LYP level. The subsequent QSAR study shows that not only the structure of repellents but also the repellent-lactic acid complexes may play an important role. It suggests that further study on interactions between repellents and characteristic compounds from human host may be required in order to understand the repelling mechanism.

Synthesis and insect attractant activity of fluorine-containing Pinus diterpenic amides and imines.

A series of fluorine-containing Pinus diterpenic amides and imines have been synthesised and their structures were confirmed by elemental analysis, IR, (1)H NMR spectroscopy and single crystal X-ray diffraction. Their insect attractant activity to Spodoptera litura were screened by leaf plate method; the results indicated that most fluorine-containing dehydroabietic amides and imines exhibited attractive activity to S. litura, in which dehydroabietic p-trifluoromethyl amide (A6) exhibit seven times the attractive rate compared with blank at the concentration of 0.

Quantitative structure-activity relationship of terpenoid aphid antifeedants.

A series of terpenoid compounds containing a six-member-ring were synthesized from alpha- and beta-pinenes. Antifeedant activity of these terpenoid compounds were tested on the aphid, Lipaphis erysimi (Kalt.), with promising results.

QSAR study of mosquito repellents from terpenoid with a six-member-ring.

A new class of low-toxicity mosquito repellents is synthesized from alpha- and beta-pinene in terpenoid compounds and preliminary biological tests show promising mosquito repellency. Statistical modeling is built using Codessa in order to reveal the quantitative relationship between the structure and the biological activity and to provide the guidance for further synthetic work.