Publications by authors named "Zhike Han"

Glaucoma is a chronic disorder that harms the optic nerves and causes irreversible blindness. The calculation of optic cup (OC) to optic disc (OD) ratio plays an important role in the primary screening and diagnosis of glaucoma. Thus, automatic and precise segmentations of OD and OC is highly preferable.

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Diabetic retinopathy (DR) is the primary cause of blindness in adults. Incorporating machine learning into DR grading can improve the accuracy of medical diagnosis. However, problems, such as severe data imbalance, persists.

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The Chinese mitten crab Eriocheir sinensis is the most economically important cultivated crab species in China, and its genome has a high number of chromosomes (2n = 146). To obtain sufficient markers for construction of a dense genetic map for this species, we employed the recently developed specific-locus amplified fragment sequencing (SLAF-seq) method for large-scale SNPs screening and genotyping in a F1 full-sib family of 149 individuals. SLAF-seq generated 127,677 polymorphic SNP markers, of which 20,803 valid markers were assigned into five segregation types and were used together with previous SSR markers for linkage map construction.

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