Observation of dynamic non-Hermitian skin effects.

Non-Hermitian physics has emerged as a new paradigm that profoundly changes our understanding of non-equilibrium systems, introducing novel concepts such as exceptional points, spectral topology, and non-Hermitian skin effects (NHSEs). Most existing studies focus on non-Hermitian eigenstates, whereas dynamic properties have been discussed only recently, and the dynamic NHSEs are not yet confirmed in experiments. Here, we report the experimental observation of non-Hermitian skin dynamics using tunable one-dimensional nonreciprocal double-chain mechanical systems with glide-time symmetry.

Observation of an acoustic topological Euler insulator with meronic waves.

Topological band theory has conventionally been concerned with the topology of bands around a single gap. Only recently non-Abelian topologies that thrive on involving multiple gaps were studied, unveiling a new horizon in topological physics beyond the conventional paradigm. Here, we report on the first experimental realization of a topological Euler insulator phase with unique meronic characterization in an acoustic metamaterial.

Measuring entanglement entropy and its topological signature for phononic systems.

Entanglement entropy is a fundamental concept with rising importance in various fields ranging from quantum information science, black holes to materials science. In complex materials and systems, entanglement entropy provides insight into the collective degrees of freedom that underlie the systems' complex behaviours. As well-known predictions, the entanglement entropy exhibits area laws for systems with gapped excitations, whereas it follows the Gioev-Klich-Widom scaling law in gapless fermion systems.

Topological phononic metamaterials.

The concept of topological energy bands and their manifestations have been demonstrated in condensed matter systems as a fantastic paradigm toward unprecedented physical phenomena and properties that are robust against disorders. Recent years, this paradigm was extended to phononic metamaterials (including mechanical and acoustic metamaterials), giving rise to the discovery of remarkable phenomena that were not observed elsewhere thanks to the extraordinary controllability and tunability of phononic metamaterials as well as versatile measuring techniques. These phenomena include, but not limited to, topological negative refraction, topological 'sasers' (i.

Hybrid topological photonic crystals.

Topologically protected photonic edge states offer unprecedented robust propagation of photons that are promising for waveguiding, lasing, and quantum information processing. Here, we report on the discovery of a class of hybrid topological photonic crystals that host simultaneously quantum anomalous Hall and valley Hall phases in different photonic band gaps. The underlying hybrid topology manifests itself in the edge channels as the coexistence of the dual-band chiral edge states and unbalanced valley Hall edge states.

Analysis of pressure pulsation and energy characteristics of guide vane for axial flow pump based on Hilbert-Huang transform considering impeller-guide vane interaction.

In order to explore the characteristics of pressure pulsation signals and energy distribution of water flow at the guide vane considering impeller-guide vane interaction. The numerical simulation of the vertical axial flow pump device's steady and unsteady three-dimensional flow fields was carried out. The Hilbert-Huang method was used to conduct empirical mode decomposition decomposition and Hilbert spectrum analysis of pressure pulsation signal at each monitoring point in the inlet and outlet regions of the guide vane.

A Disease-Prediction Protocol Integrating Triage Priority and BERT-Based Transfer Learning for Intelligent Triage.

Large hospitals can be complex, with numerous discipline and subspecialty settings. Patients may have limited medical knowledge, making it difficult for them to determine which department to visit. As a result, visits to the wrong departments and unnecessary appointments are common.

Identification of Six Diagnostic Biomarkers for Chronic Lymphocytic Leukemia Based on Machine Learning Algorithms.

Background: Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in adults. Thus, novel reliable biomarkers need to be further explored to increase diagnostic, therapeutic, and prognostic effectiveness.

Methods: Six datasets containing CLL and control samples were downloaded from the Gene Expression Omnibus database.

Observation of Topological p-Orbital Disclination States in Non-Euclidean Acoustic Metamaterials.

Disclinations-topological defects ubiquitously existing in various materials-can reveal the intrinsic band topology of the hosting material through the bulk-disclination correspondence. In low-dimensional materials and nanostructure such as graphene and fullerenes, disclinations yield curved surfaces and emergent non-Euclidean geometries that are crucial in understanding the properties of these materials. However, the bulk-disclination correspondence has never been studied in non-Euclidean geometry, nor in systems with p-orbital physics.

Analysis of Energy Loss Characteristics of Vertical Axial Flow Pump Based on Entropy Production Method under Partial Conditions.

The energy loss of the vertical axial flow pump device increases due to the unstable internal flow, which reduces the efficiency of the pump device and increases its energy consumption of the pump device. The research results of the flow loss characteristics of the total internal conduit are still unclear. Therefore, to show the internal energy loss mechanism of the axial flow pump, this paper used the entropy production method to calculate the energy loss of the total conduit of the pump device to clarify the internal energy loss mechanism of the pump device.

Observation of Emergent Dirac Physics at the Surfaces of Acoustic Higher-Order Topological Insulators.

Using 3D sonic crystals as acoustic higher-order topological insulators (HOTIs), 2D surface states described by spin-1 Dirac equations at the interfaces between the two sonic crystals with distinct topology but the same crystalline symmetry are discovered. It is found that the Dirac mass can be tuned by the geometry of the two sonic crystals. The sign reversal of the Dirac mass reveals a surface topological transition where the surface states exhibit zero refractive index behavior.

Topological Wannier cycles induced by sub-unit-cell artificial gauge flux in a sonic crystal.

Gauge fields play a major role in understanding quantum effects. For example, gauge flux insertion into single unit cells is crucial towards detecting quantum phases and controlling quantum dynamics and classical waves. However, the potential of gauge fields in topological materials studies has not been fully exploited.

PINCH1 knockout aggravates myocardial infarction in mice via mediating the NF-κB signaling pathway.

Myocardial infarction (MI), the leading cause of death among patients with cardiovascular diseases, is characterized by acute cardiac muscle injury due to severe impairment of the coronary blood supply, which may lead to cardiogenic shock and cardiac arrest. Particularly interesting new cysteine histidine rich 1 (PINCH1) protein, a key component of the integrin signaling pathway, interacts with several proteins and serves a vital role in numerous cellular processes, including cytoskeleton remodeling, cell proliferation and cell migration. To investigate the role of PINCH1 in heart injury in the present study, PINCH1 was knocked out in the myocardial tissue of mice (age, 18 weeks) to induce MI.

Observation of Acoustic Skyrmions.

Despite a long history of studies, acoustic waves are generally regarded as spinless scalar waves, until recent research revealed their rich structures. Here, we report the experimental observation of skyrmion configurations in acoustic waves. We find that surface acoustic waves trapped by a designed hexagonal acoustic metasurface give rise to skyrmion lattice patterns in the dynamic acoustic velocity fields (i.

On-chip higher-order topological micromechanical metamaterials.

Metamaterials with higher-order topological band gaps that exhibit topological physics beyond the bulk-edge correspondence provide unique application values due to their ability of integrating topological boundary states at multiple dimensions in a single chip. On the other hand, in the past decade, micromechanical metamaterials are developing rapidly for various applications such as micro-piezoelectric-generators, intelligent micro-systems, on-chip sensing and self-powered micro-systems. To empower these cutting-edge applications with topological manipulations of elastic waves, higher-order topological mechanical systems working at high frequencies (MHz) with high quality-factors are demanded.

MicroRNA-24 protects against myocardial ischemia-reperfusion injury via the NF-κB/TNF-α pathway.

Acute myocardial infarction (AMI) is a form of cardiomyopathy in which a blocked coronary artery leads to an irreversible loss of cardiomyocytes due to inadequate blood and oxygen supply to the distal myocardium tissues, eventually leading to heart failure. Recently, studies have revealed that microRNA (miRNA/miR)-24 has diagnostic value in the pathogenesis of AMI by affecting multiple cell processes such as cell proliferation, differentiation and apoptosis. However, the specific mechanism of miR-24 in ischemia-reperfusion injury (IRI) after AMI remains to be fully elucidated.

Observation of a phononic higher-order Weyl semimetal.

Weyl semimetals (WSMs) exhibit phenomena such as Fermi arc surface states, pseudo-gauge fields and quantum anomalies that arise from topological band degeneracy in crystalline solids for electrons and metamaterials for photons and phonons. Here we report a higher-order Weyl semimetal (HOWSM) in a phononic system that exhibits topologically protected boundary states in multiple dimensions. We created the physical realization of the HOWSM in a chiral phononic crystal with uniaxial screw symmetry.

Bulk-disclination correspondence in topological crystalline insulators.

Most natural and artificial materials have crystalline structures from which abundant topological phases emerge. However, the bulk-edge correspondence-which has been widely used in experiments to determine the band topology from edge properties-is inadequate in discerning various topological crystalline phases, leading to challenges in the experimental classification of the large family of topological crystalline materials. It has been theoretically predicted that disclinations-ubiquitous crystallographic defects-can provide an effective probe of crystalline topology beyond edges, but this has not yet been confirmed in experiments.

Higher-Order Weyl Semimetals.

Higher-order topology yields intriguing multidimensional topological phenomena, while Weyl semimetals have unconventional properties such as chiral anomaly. However, so far, Weyl physics remain disconnected with higher-order topology. Here, we report the theoretical discovery of higher-order Weyl semimetals and thereby the establishment of such an important connection.

Higher-Order Topological States in Surface-Wave Photonic Crystals.

Photonic topological states have revolutionized the understanding of the propagation and scattering of light. The recent discovery of higher-order photonic topological insulators opens an emergent horizon for 0D topological corner states. However, the previous realizations of higher-order topological insulators in electromagnetic-wave systems suffer from either a limited operational frequency range due to the lumped components involved or a bulky structure with a large footprint, which are unfavorable for achieving compact photonic devices.