PANoptosis-related genes in the prognosis and immune landscape of hepatocellular carcinoma.

In hepatocellular carcinoma (HCC) individuals, the influence of numerous variables on the HCC prognosis has gained widespread recognition. Nevertheless, there remains a need for further elucidation regarding the underlying mechanism of PANoptosis-related genes (PRGs) on HCC. A consensus clustering approach, based on the TCGA-LIHC data, was used to identify specific subtypes linked to PANoptosis in this study.

Formosanin C induces autophagy-mediated cell death in hepatocellular carcinoma through activating DUSP1/AMPK/ULK1/Beclin1 signaling pathway.

Background: Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers and is associated with poor survival. Formosanin C (FC) is a diosgenin glycoside extracted from Paris polyphylla. Therapeutic effects of FC against HCC malignancies remain unclear.

Disulfiram/Cu targeting FOXO6 modulates sensitivity of hepatocellular carcinoma to lenvatinib via disrupt choline metabolic.

Disulfiram/Cu(DSF/Cu) has a known pharmacokinetic and safety profile, exerting a strong antitumor effect. Oral tyrosine kinase inhibitors including lenvatinib are approved as first-line therapy for treating advanced unresectable hepatocellular carcinoma (HCC). These patients still have limited survival due to drug resistance.

Corynoxine exerts the anti-tumor effect on esophageal squamous cell carcinoma principally via the EZH2-DUSP5-ERK1/2-mediated cell growth inhibition.

Background: Esophageal cancer is one of the most prevalent malignant tumors and the sixth largest cause of tumor-associated death worldwide. Squamous cell carcinoma (ESCC) accounts for 85 % of all esophageal cancer cases. ESCC treatment remains to be significantly difficult.

Phloretin-induced STAT3 inhibition suppresses pancreatic cancer growth and progression via enhancing Nrf2 activity.

Background: Pancreatic ductal adenocarcinoma (PDAC) is a malignant pancreatic tumor charactered by a rapid progression and high lethal rate. Hyperactivation of STAT3 signaling exerts a vital effect on the growth and progression of PDAC. While dietary flavonoid phloretin has anti-inflammatory and antioxidant activities, it remains unclear whether phloretin has anti-tumor effects on PDAC.

Amino Acid Metabolism-Related lncRNA Signature Predicts the Prognosis of Breast Cancer.

Breast cancer (BRCA) is the most frequent female malignancy and is potentially life threatening. The amino acid metabolism (AAM) has been shown to be strongly associated with the development and progression of human malignancies. In turn, long noncoding RNAs (lncRNAs) exert an important influence on the regulation of metabolism.

Solvothermal synthesis of Mn-doped CsPbCl perovskite nanocrystals with tunable morphology and their size-dependent optical properties.

Doping metal ions in inorganic halide perovskite (CsPbX, X = Cl, Br, I) nanocrystals (NCs) endows the NCs with unique optical characteristics, and has thus attracted immense attention. However, controllable synthesis of high-quality doped perovskite NCs with tunable morphology still remains challenging. Here, we report a facile, effective and unified strategy for the controllable synthesis of Mn-doped CsPbCl quantum dots (QDs) and nanoplatelets (NPLs) a single-step solvothermal method.

Controllable synthesis of CsPbI nanorods with tunable photoluminescence emission.

So far the controllable synthesis of one-dimensional (1D) CsPbI nanocrystals still remains a challenge due to the fast reaction kinetics of the iodine system as compared with other halide perovskites. Here we report the direct synthesis of high-quality 1D CsPbI nanorods by a facile solvothermal method. The as-prepared CsPbI nanorods show high purity and uniform morphology with ultrafine diameters down to ∼5 nm.

Solvothermal synthesis of cesium lead halide perovskite nanowires with ultra-high aspect ratios for high-performance photodetectors.

One-dimensional (1D) inorganic perovskite nanowires (NWs) have attracted promising attention for application in the fields of photodetection, lasers and lighting due to their outstanding optoelectronic properties. However the direct synthesis of highly pure all-inorganic perovskite NWs with well-defined morphologies and compositions still remains challenging. Here we report the controllable synthesis of brightly emitting cesium lead halide CsPbX (X = Cl, Br) NWs and their assembly into high-performance photodetector nanodevices.