Secondary Metabolites with Agricultural Antagonistic Potential from sp. ITBBc1, a Coral-Associated Marine Fungus.

A marine-derived fungal strain, sp. ITBBc1, was isolated from coral collected from the South China Sea in Hainan province. Intensive chemical investigation of the fermentation extract of this strain afforded four new secondary metabolites (-), named megastigmanones A-C and prenylterphenyllin H, along with four known compounds (-).

Critical Secondary Metabolites Confer the Broad-Spectrum Pathogenic Fungi Resistance Property of a Marine-Originating sp. HNBCa1.

Obtaining a microorganism strain with a broad-spectrum resistance property and highly efficient antifungal activity is important to the biocontrol strategy. Herein, a marine sp. HNBCa1 demonstrated a broad-spectrum resistance to 17 tested crop pathogenic fungi and exhibited a high biocontrol efficiency against mango anthracnose and banana fusarium wilt.

Identification of a natural PLA2 inhibitor from the marine fungus sp. c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1/XBP-1s axis and JNK signaling.

Lipotoxicity is a pivotal factor that initiates and exacerbates liver injury and is involved in the development of metabolic-associated fatty liver disease (MAFLD). However, there are few reported lipotoxicity inhibitors. Here, we identified a natural anti-lipotoxicity candidate, HN-001, from the marine fungus sp.

Short-term wind speed prediction based on improved Hilbert-Huang transform method coupled with NAR dynamic neural network model.

Wind energy, as a renewable energy source, offers the advantage of clean and pollution-free power generation. Its abundant resources have positioned wind power as the fastest-growing and most widely adopted method of electricity generation. Wind speed stands as a key characteristic when studying wind energy resources.

COSMO-RS guided screening of ionic liquids for the separation of fluorinated greenhouse gases R-410A: Delving into anion, cation effects, and hydrogen bond dynamics.

Reclamation of high-GWP near-azeotropic refrigerant R-410A (50 wt% R-32 (difluoromethane) + 50 wt% R-125 (pentafluoroethane)) can be an effective way to mitigate the greenhouse effect and achieve a circular economy. Efficient ionic liquids (ILs) as extractants needed to be found for the extractive distillation (ED) separation process of R-410A. Given the numerous combinations of cations and anions in ILs, the discovery of an efficient IL via experimental methods proves to be an exceedingly complex task.

Comparison between different treatment regimens of vascular targeting drug to malignant pleural effusion in patients with lung cancer: A Bayesian network meta-analysis.

Background: The presence of malignant pleural effusion in lung cancer patients often suggests a poor prognosis. We plan to investigate which regimen of vascular targeting drug is preferable to control the malignant pleural effusion in such patients.

Methods: Two investigators dependently searched and screened for randomized controlled trials in PubMed, Embase, Web of Science and China National Knowledge Infrastructure from the database inception to August 2022.

New Isocoumarin and Pyrone Derivatives from the Chinese Mangrove Plant -Associated Fungus sp. DHS-11.

Mangrove-associated fungi are important sources for the discovery of new bioactive natural products. Three new isocoumarins (-) and one new pyrone derivative () were isolated from the ethyl acetate extract of the fermentation broth of the mangrove endophytic fungus sp. DHS-11.

Urban Flooding Prediction Method Based on the Combination of LSTM Neural Network and Numerical Model.

At present, urban flood risk analysis and forecasting and early warning mainly use numerical models for simulation and analysis, which are more accurate and can reflect urban flood risk well. However, the calculation speed of numerical models is slow and it is difficult to meet the needs of daily flood control and emergency. How to use artificial intelligence technology to quickly predict urban flooding is a key concern and a problem that needs to be solved.

Seven drimane-type sesquiterpenoids from an earwig-associated Aspergillus sp.

Drimane-type sesquiterpenoids are widely distributed in fungi. From the ethyl acetate extract of the earwig-derived Aspergillus sp. NF2396, seven new drimane-type sesquiterpenoids, named drimanenoids A-G (1-7), were isolated.

Isolation and Identification of Secondary Metabolites Produced by Phytopathogenic Fungus from .

The secondary metabolites of the phytopathogenic fungus CC01 from were investigated. As a result, two new compounds, 5-acetyl-7-hydroxy-6- methoxybenzofuran-2(3)-one () and ()-2-(2,3-dihydrofuro [3,2-]pyridin-2-yl)propan-2-ol (), together with seven known compounds, 4,6,8-trihydroxy-3,4-dihydronaphthalen-1(2)-one (), 3,6,8-trihydroxy-3,4-dihydronaphthalen-1(2)-one (), curvulin acid (), 2-methyl-5-carboxymethyl- 7-hydroxychromone (), tyrosol (), -hydroxybenzoic acid () and cerevisterol (), were isolated from the fermentation extract by comprehensive silica gel, reverse phase silica gel, Sephadex-LH20 column chromatography and high-performance liquid chromatography (HPLC). The structures of these compounds were identified by using high-resolution electrospray mass spectrometry (HRESIMS), nuclear magnetic resonance spectroscopy (NMR), optical rotation, ultraviolet and infrared spectroscopy techniques and a comparison of NMR data with those reported in the literature.

Discovery of -Terphenyl Metabolites as Potential Phosphodiesterase PDE4D Inhibitors from the Coral-Associated Fungus sp. ITBBc1.

Chemical investigation of the fermentation extract of the coral-associated fungus sp. ITBBc1 led to the discovery of five unreported -terphenyl derivatives, sanshamycins A-E (-), together with five previously described analogues, terphenyllin (), 3-hydroxyterphenyllin (), candidusin A (), 4,5-dimethoxycandidusin A (), and candidusin C (). Their structures were elucidated by HRESIMS data and NMR spectroscopic analysis.

New antibacterial depsidones from an ant-derived fungus Spiromastix sp. MY-1.

Six new (1-6) and seven known depsidones (7-13) were isolated from the culture of an ant (Monomorium chinensis)-derived fungus Spiromastix sp. MY-1. Their structures were elucidated by extensive spectroscopic analysis including high resolution MS, 1D and 2D NMR data.

Zhaoshumycins A and B, Two Unprecedented Antimycin-Type Depsipeptides Produced by the Marine-Derived sp. ITBB-ZKa6.

Marine actinomycetes are prolific chemical sources of complex and novel natural products, providing an excellent chance for new drug discovery. The chemical investigation of the marine-derived sp. ITBB-ZKa6, from Zhaoshu island, Hainan, led to the discovery of two unique antimycin-type depsipeptides, zhaoshumycins A () and B (), along with the isolation of the four known neoantimycins A (), F (), D (), and E ().

Shoreanol A and B, unprecedented oligostilbenoids from the twigs of Shorea obtusa Wall.

Chemical investigation of the twigs extract of tropical dipterocarpaceous plant Shorea obtusa Wall led to the isolation of two previously undescribed oligostilbenoids, including a structurally unusual resveratrol aneuploid named shoreanol A (1) and a new resveratrol trimer derivative named shoreanol B (2). Their structures and relative configurations were determined by comprehensive spectroscopic analysis and comparison with previously reported compound. Shoreanol A (1) was identified as a rare natural resveratrol aneuploid possessing a novel carbon skeleton through condensation of three resveratrol monomer and one benzyl moiety, which is the first example in the Dipterocarpaceae.

Genomic characteristics and comparative genomics analysis of the endophytic fungus Sarocladium brachiariae.

Background: Sarocladium brachiariae is a newly identified endophytic fungus isolated from Brachiaria brizantha. A previous study indicated that S. brachiariae had antifungal activity; however, limited genomic information restrains further study.

Bioactive phenazines from an earwig-associated Streptomyces sp.

Three new phenazine-type compounds, named phenazines SA-SC (1-3), together with four new natural products (4-7), were isolated from the fermentation broth of an earwig-associated Streptomyces sp. NA04227. The structures of these compounds were determined by extensive analyses of NMR, high resolution mass spectroscopic data, as well as single-crystal X-ray diffraction measurement.

A new flavonoid derivative and a new 5-hydroxyanthranilic acid derivative from the sea urchin-derived sp. HDa1.

One new flavonoid derivative flavoside A (), one new 5-hydroxyanthranilic acid derivative crassilin (), along with the known angucyclinone PD116740 () and oxachelin (), was isolated from the EtOAc extract of the fermentation broth of the sea urchin ()-derived actinobacterium, sp. HD01. The structures of these compounds were established on the basis of their HR-ESI-MS and NMR spectroscopic data.

Anthocidins A⁻D, New 5-Hydroxyanthranilic Acid Related Metabolites from the Sea Urchin-Associated Actinobacterium, Streptomyces sp. HDa1.

Four new 5-hydroxyanthranilic acid related compounds, named anthocidins A⁻D (⁻), two known analogues -lauryl 5-hydroxyanthranilate () and isolauryl 5-hydroxyanthranilate (), together with benzamide (), 3-hydroxy-4-methoxycinnamamide (), and (3-)-hexahydro-3-[(3,4-dihydroxyphenyl)methyl]pyrrolo[1,2-]pyrazine-1,4-dione (), were isolated from the fermentation broth of the marine-derived actinomycete, sp. HDa1, which was isolated from the gut of a sea urchin, , collected from Hainan Island, China. The structures of these secondary metabolites were elucidated on the basis of their 1D and 2D-NMR and mass spectroscopic data, and anthocidin A was confirmed by single-crystal X-ray diffraction with Cu Kα radiation.

New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54.

Four new eudesmane-type sesquiterpenoids, penicieudesmol A-D (-), were isolated from the fermentation broth of the mangrove-derived endophytic fungus sp. J-54. Their structures were determined by spectroscopic methods, the in situ dimolybdenum CD method, and modified Mosher's method.

New Antibacterial Phenone Derivatives Asperphenone A-C from Mangrove-Derived Fungus Aspergillus sp. YHZ-1.

Marine fungi are a promising source of novel bioactive natural products with diverse structure. In our search for new bioactive natural products from marine fungi, three new phenone derivatives, asperphenone A-C (-), have been isolated from the ethyl acetate extract of the fermentation broth of the mangrove-derived fungus, sp. YHZ-1.

Discovery of the leinamycin family of natural products by mining actinobacterial genomes.

Nature's ability to generate diverse natural products from simple building blocks has inspired combinatorial biosynthesis. The knowledge-based approach to combinatorial biosynthesis has allowed the production of designer analogs by rational metabolic pathway engineering. While successful, structural alterations are limited, with designer analogs often produced in compromised titers.

Metabolites with Insecticidal Activity from Aspergillus fumigatus JRJ111048 Isolated from Mangrove Plant Acrostichum specioum Endemic to Hainan Island.

Fungi residing in mangroves are considered to be a bank of novel bioactive natural products. In the screening for bioactive metabolites from mangrove-derived fungi, the ethyl acetate extract of the fermentation broth of JRJ111048, a fungus isolated from the leaves of the mangrove plant endemic to Hainan island, was found to possess insecticidal activity against . Bioactivity-guided isolation lead to the discovery of seven metabolites -, including one new anhydride derivative aspergide (), one new lipid amide 11-methyl-11-hydroxyldodecanoic acid amide (), and five known compounds; α-ethyl glucoside (), spiculisporic acid B (), spiculisporic acid C (), spiculisporic acid (), and secospiculisporic acid B ().

A new insecticidal havanensin-type limonoid from the roots of Bentv.

One new havanensin-type limonoid () named trisinlin A with two known compounds (4,8)-2-[2'-hydroxyhexadecanoyl amino]-4,8-octadecadiene-1,3-diol (), 9-octadecenoic acid-2',3'-dihydroxypropyl ester () were isolated from the roots of . The structure of the new compound was unambiguously determined through comprehensive spectroscopic analyses including 1D and 2D NMR, and mass spectrometry, as well as by comparison with the literature. Trisinlin A showed significant insecticidal activity against newly hatched larvae of .

Daphnauranins A and B, two new antifeedants Isolated from Daphne aurantiaca roots.

Daphnauranins A (1) and B (2), two sesquiterpenoids were isolated from the roots of Daphne aurantiaca Diels. One is an unprecedented 5/7 oxacycloheptane ring system, the other is a sesquiterpene-lignan complex. Their structures were elucidated by comprehensive spectroscopic methods including MS and NMR.