A detailed simulation study on radionuclide dispersion under spent fuel road transportation conditions: Effects of vessel type and coniferous vegetation growth.

Vegetation barriers are an important environmental characteristic of spent fuel road transportation accidents. Spent fuel vessels may be affected by force majeure factors during transportation, which leads to damage to spent fuel assemblies and containers and can cause radionuclides to gradually release from assemblies to vessels to the external environment. In this work, considering the growth periods of coniferous vegetation barriers and vessel type, a radionuclide dispersion model based on computational fluid dynamics (CFD) was established by adding a decay term and a pressure loss term.

Exploring the top 30 drugs associated with drug-induced constipation based on the FDA adverse event reporting system.

Objective: This project aims to identify the top 30 drugs most commonly associated with constipation and their signal values within the FDA Adverse Event Reporting System database.

Methods: We extracted adverse drug events (ADEs) related to constipation from the FAERS database spanning from January 1, 2004, to September 30, 2023. We compiled the 30 most frequently reported drugs based on the frequency of constipation events.

Comparative study of [F]AlF-PAI-PDL1p and [Ga]Ga-PAI-PDL1p as novel PD-L1 targeting PET probes for tumor imaging.

PD-L1 is expressed in many tumors but rarely in normal tissues, therefore, it can be a target of PET imaging. In this work, we developed new peptide-based PET probes [F]AlF-PAI-PDL1p and [Ga]Ga-PAI-PDL1p with yields of 20-25 % and 40-55 %, respectively. [F]AlF-PAI-PDL1p and [Ga]Ga-PAI-PDL1p were synthesized within 30 min with high molar activities.

Cerebral [F]AIF-FAPI-42-Based PET Imaging of Fibroblast Activation Protein for Non-invasive Quantification of Fibrosis After Ischemic Stroke.

The development of fibrosis after injury to the brain or spinal cord limits the regeneration of the central nervous system in adult mammals. However, the extent of fibrosis in the injured brain has not been systematically investigated in mammals in vivo. This study aimed to assess whether [F]AlF-FAPI-42-based cerebral positron emission tomography (PET) can be utilized to assess the extent of fibrosis in ischemic regions of the brain in vivo.

Synthesis and preclinical evaluation of a novel PET/fluorescence dual-modality probe targeting fibroblast activation protein.

Early diagnosis and precise surgical intervention are crucial for cancer patients. We aimed to develop a novel positron emission tomography (PET)/fluorescence dual-modality probe for preoperative diagnosis, intraoperative guidance, and postoperative monitoring of fibroblast activation protein (FAP)-positive tumors. FAPI-FAM was synthesized and labeled with gallium-68.

Lu-Labeled Bivalent Ligands of Prostate-Specific Membrane Antigen for Endoradiotherapy of Prostate Cancer.

Recently, we developed a bivalent prostate-specific membrane antigen (PSMA) radioligand ([F]AlF-Bi-PSMA), which showed higher tumor uptake and retention in PSMA-positive mouse models than the clinically used radioligands, [Ga]Ga-PSMA-11 and [F]PSMA-1007. Here, we developed two Lu-labeled bivalent PSMA ligands with (DOTA-Alb-Bi-PSMA) or without an albumin-binding motif (DOTA-Bi-PSMA) to enhance radiotherapeutic efficacy with minimal toxicity. The results demonstrated that both Lu-labeled bivalent radioligands showed good stability, high binding affinity, and PSMA-targeting specificity in vitro.

Synthesis and preclinical evaluation of novel F-labeled fibroblast activation protein tracers for positron emission tomography imaging of cancer-associated fibroblasts.

Fibroblast activation protein (FAP) is overexpressed in cancer-associated fibroblasts in more than 90% of epithelial tumors. Several radiotracers targeting FAPs have been used in clinical settings in recent years. However, the number of F-labeled FAP tracers is still limited.