Self-synergy-powered Ni/Fe nanocube-based cholesterol detection with dual modes.

Nanoenzyme-leveraged multimode detection would benefit enhancing sensitivity and mitigating detection error. Moreover, multienzyme-like nanozymes hold tremendous potential in sensing by offering synergistic effects and cascaded catalysis. Herein, cost-effective multienzymic Ni/Fe nanocubes (Ni/FeNCs) were synthesized via a facile co-precipitation, and verified to catalyze HO decomposition as peroxidase (POD) and catalase (CAT) mimics.