Syrosingopine and UK5099 synergistically suppress non-small cell lung cancer by activating the integrated stress response.

Non-small cell lung cancer (NSCLC) presents a global health challenge due to its low five-year survival rates, underscoring the need for novel therapeutic strategies. Our research explored the synergistic mechanisms of syrosingopine and UK-5099 in treating NSCLC. In vitro experiments showed that the combination of syrosingopine and UK-5099 significantly synergized to suppress NSCLC proliferation.

Relationship between BUN/Cr and Prognosis of HF Across the Full Spectrum of Ejection Fraction.

Background: In patients with heart failure (HF), due to the relative deficiency of blood volume, neurohormone system activation leads to renal vasoconstriction, which affects the content of blood urea nitrogen (BUN) and creatinine (Cr) in the body, while BUN and Cr are easily affected by other factors. Therefore, BUN/Cr can be used as another marker for the prognosis of HF.

Objective: Explore the prognosis of adverse outcome of HF in the high BUN/Cr group compared with the low BUN/Cr group across the full spectrum of ejection fraction.

Application of hospital-community-family health education to family caregivers of nasal fed patients under the background of a regional medical association.

Background: Patients with nasogastric tube (NTG) nutrition after discharge still need to be transferred to community hospitals for continued care. Effective health education is conducive to raising the level of knowledge of caregivers to promote the rehabilitation of patients.

Methods: Clinical data of 65 caregivers of stroke patients in Putuo Hospital affiliated to Shanghai University of Traditional Chinese Medicine from June 2020 to December 2020 were retrospectively analyzed.

WITHDRAWN: The clinical application of an innovative tracheotomy fixation belt in critically ill patients.

Ahead of Print article withdrawn by publisher.