Gene regulatory network (GRN) inference based on single-cell RNA sequencing data (scRNAseq) plays a crucial role in understanding the regulatory mechanisms between genes. Various computational methods have been employed for GRN inference, but their performance in terms of network accuracy and model generalization is not satisfactory, and their poor performance is caused by high-dimensional data and network sparsity. In this paper, we propose a self-supervised method for gene regulatory network inference using single-cell RNA sequencing data (CVGAE).
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June 2024
The advent of single-cell RNA sequencing (scRNA-seq) technology has revolutionized gene expression studies at the single-cell level. However, the presence of technical noise and data sparsity in scRNA-seq often undermines the accuracy of subsequent analyses. Existing methods for denoising and imputing scRNA-seq data often rely on stringent assumptions about data distribution, limiting the effectiveness of data recovery.
View Article and Find Full Text PDFEntropy (Basel)
September 2022
Infrared-visible fusion has great potential in night-vision enhancement for intelligent vehicles. The fusion performance depends on fusion rules that balance target saliency and visual perception. However, most existing methods do not have explicit and effective rules, which leads to the poor contrast and saliency of the target.
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