βAR-mTOR-lipin1 pathway mediates PKA-RIIβ deficiency-induced adipose browning.

Enhancing white adipose tissue (WAT) browning combats obesity. The RIIβ subunit of cAMP-dependent protein kinase (PKA) is primarily expressed in the brain and adipose tissue. Deletion of the hypothalamic RIIβ gene centrally induces WAT browning, yet the peripheral mechanisms mediating this process remain unexplored.

RIIβ-PKA in GABAergic Neurons of Dorsal Median Hypothalamus Governs White Adipose Browning.

The RIIβ subunit of  cAMP-dependent protein kinase A (PKA) is expressed in the brain and adipose tissue. RIIβ-knockout mice show leanness and increased UCP1 in brown adipose tissue. The authors have previously reported that RIIβ reexpression in hypothalamic GABAergic neurons rescues the leanness.

Soft Magnetic Microrobot Doped with Porous Silica for Stability-Enhanced Multimodal Locomotion in a Nonideal Environment.

As an emerging field of robotics, magnetic-field-controlled soft microrobot has broad application prospects for its flexibility, locomotion diversity, and remote controllability. Magnetic soft microrobots can perform multimodal locomotion under the control of a magnetic field, which may have potential applications in precision medicine. However, previous research studies mainly focus on new locomotion in a relatively ideal environment, lacking exploration on the ability of magnetic microrobot locomotion to resist external disturbances and proceed in a nonideal environment.

Withaferin A Promotes White Adipose Browning and Prevents Obesity Through Sympathetic Nerve-Activated Prdm16-FATP1 Axis.

The increasing prevalence of obesity has resulted in demands for the development of new effective strategies for obesity treatment. Withaferin A (WA) shows a great potential for prevention of obesity by sensitizing leptin signaling in the hypothalamus. However, the mechanism underlying the weight- and adiposity-reducing effects of WA remains to be elucidated.

The Nrf2-NLRP3-caspase-1 axis mediates the neuroprotective effects of Celastrol in Parkinson's disease.

Parkinson's disease (PD) is a chronic neurodegenerative disorder that is characterized by motor symptoms as a result of a loss of dopaminergic neurons in the substantia nigra pars compacta (SNc), accompanied by chronic neuroinflammation, oxidative stress, formation of α-synuclein aggregates. Celastrol, a potent anti-inflammatory and anti-oxidative pentacyclic triterpene, has emerged as a neuroprotective agent. However, the mechanisms by which celastrol is neuroprotective in PD remain elusive.

High irisin and low BDNF levels in aqueous humor of high myopia.

Background: The pathogenesis of myopia remains unclear. Both genetic and environmental factors play a role in the disease progression. Reasons including reduced physical activity (PA) and low-grade intraocular inflammation may be involved in the development of myopia.

The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson's disease.

The pathogenesis of Parkinson's disease (PD) remains unclear, and there is no disease-modifying agent for PD. Withaferin A (WA), a naturally occurring compound, has emerged as a neuroprotective agent. However, the mechanisms by which WA is neuroprotective in PD are unknown.

A longitudinal study reveals the alterations of the Microtus fortis colonic microbiota during the natural resistance to Schistosoma japonicum infection.

The gut microbiota has been demonstrated to associate with protection against helminth infection and mediate via microbial effects on the host humoral immunity. As a non-permissive host of Schistosoma japonicum, the Microtus fortis provides an ideal animal model to be investigated, because of its natural self-healing capability. Although researches on the systemic immunological responses have revealed that the host immune system contributes a lot to the resistance, the role of gut microbiome remains unclear.

The effect of combined ecological remediation (plant microorganism modifier) on rare earth mine wasteland.

Due to the vegetation destruction and soil desertification caused by excessive exploitation at Ganzhou ion-type rare earth mine in the mid-1980s, it is essential to carry out ecological remediation. The symbiotic mycorrhiza formed by the developed perennial ryegrass (Lolium perenne L.) roots infected with arbuscular mycorrhizal fungi (AMF) can significantly improve the growth and resistance of plants.

Association between Take-Out Food Consumption and Obesity among Chinese University Students: A Cross-Sectional Study.

Background: The frequency of take-out food consumption has increased rapidly among Chinese college students, which has contributed to high obesity prevalence. However, the relationships between take-out food consumption, body mass index (BMI), and other individual factors influencing eating behavior among college students are still unclear. This study explored the association of take-out food consumption with gender, BMI, physical activity, preference for high-fat and high-sugar (HFHS) food, major category, and degree level among Chinese college students.

Geniposide regulates the miR-101/MKP-1/p38 pathway and alleviates atherosclerosis inflammatory injury in ApoE mice.

Atherosclerosis (AS) is the common pathological basis of chronic cardiovascular diseases and is associated with inflammation and lipid metabolism dysfunction. Geniposide, the main active ingredient of Gardenia jasminoides Ellis fruit, exhibits a variety of anti-inflammatory and anti-oxidative functions; however, its role in AS remains unclear. The aim of this study was to investigate the mechanisms of geniposide in alleviating inflammation and thereby attenuating the development of AS.

[Protein Kinase A and Lipid Metabolism].

Protein kinase A(PKA),as a pivotal factor in the cellular signal transduction,plays an es-sential role in the regulation of lipid metabolism.PKA activates the key lipases including hormone sensi-tive lipase (HSL)and adipose triglyceride lipase (ATGL)to promote the fat mobilization.PKA signaling up-regulates the mitochondrial thermogenesis by enhancing the expression of uncoupling protein-1 (UCP-1),which critically contributes to the body heat production.

Research of micro-prism distribution on the bottom surface of the small-size integrated light guide plate.

The luminance uniformity of the backlight module (BLM) importantly depends on the microstructure distribution on the bottom surface of the light guide plate (LGP). Based on the small-size integrated LGP (ILGP) proposed, we put forward a distribution expression of micro-prisms on the bottom surface of the ILGP, and present the relational expressions between the coefficients of the analytical expression and the structural parameters of the ILGP, such as the light guide length L, width of the ILGP W, thickness of the ILGP H, and space between light emitting diodes (LEDs) d. Then, the research results above are applied to the design of the small-size ILGPs.

Algorithm research on microstructure distribution on the bottom surface of an integrated micro-optical light guide plate.

Based on the backlight module (BLM) with an integrated micro-optical light guide plate (MOLGP) that we proposed [Opt. Express21, 20159 (2013)], an optical model that maps the relationship between the distribution of microprisms on the bottom surface of the integrated MOLGP and the luminance of the output light is established by a backpropagation neural network in this paper. Then the optimized distribution of the microprisms for high luminance uniformity of the output light is obtained by a genetic algorithm.

Integrated micro-optical light guide plate.

In this paper, we propose an integrated micro-optical light guide plate (MOLGP), of which the top surface is designed as aspheric semi-cylindrical micro-concentrator structure (ASCMCS) arrays and the bottom surface is fused with micro-prism arrays coated with a high-reflective film. And we also present the optimized structural parameters and distribution pattern of the MOLGP. By the simulation of the professional optical software Lighttools, it's verified that the integrated MOLGP we proposed can achieve the functions of five complex-structure films in current typical backlight module (BLM), and the Five Parameters (light energy utilization efficiency, average illuminance and luminance, uniformity of illuminance and uniformity of luminance) in the BLM with integrated MOLGP are respectively 1.