Preliminary study on the potential impact of probiotic combination therapy on infection in children using 16S gene sequencing and untargeted metabolomics approach.

Objective: The purpose of this study was to explore the potential mechanism of (Hp) eradication by probiotic therapy through 16S rRNA gene sequencing technology and untargeted metabolomics.

Methods: Twenty four Hp-infected children were recruited from the Shanxi Bethune Hospital, and 24 healthy children were recruited as a blank control group. Group A: fecal samples from 24 healthy children.

"Pseudosubstrate Envelope"/Free Energy Perturbation-Guided Design and Mechanistic Investigations of Benzothiazole HIV Capsid Modulators with High Ligand Efficiency.

Based on our proposed "pseudosubstrate envelope" concept, 25 benzothiazole-bearing HIV capsid protein (CA) modulators were designed and synthesized under the guidance of free energy perturbation technology. The most potent compound, , exhibited an EC of 2.69 nM against HIV-1, being 393 times more potent than the positive control PF74.

Discovery of a Novel Thienopyrimidine Compound as a Urate Transporter 1 and Glucose Transporter 9 Dual Inhibitor with Improved Efficacy and Favorable Druggability.

Gout and hyperuricemia are metabolic diseases characterized with high serum uric acid (SUA) levels that significantly impact human health. Lesinurad, a uricosuric agent, is limited to concurrent use with xanthine oxidase inhibitors (XOIs) in clinical practice due to its restricted efficacy and potential nephrotoxicity. Herein, extensive structural modifications of lesinurad were conducted through scaffold hopping and substituent modification strategies, affording 54 novel derivatives containing pyrimidine-fused cyclic structures.

A clinical study of the correlation between metabolic-associated fatty liver disease and coronary plaque pattern.

Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome (MetS) and has been correlated with coronary atherosclerosis (CAS). Since NAFLD was renamed metabolic-associated fatty liver disease(MAFLD) in 2020, no studies have evaluated the correlation between MAFLD and CAS. The aim of this study was to evaluate the relationship between MAFLD and CAS.

Developing Chinese race-specific warfarin dose prediction algorithms.

Background: Numerous genotype-guided warfarin dosing algorithms have been developed to individualize warfarin doses, but they can only explain 47-52% of the variability.

Aim: This study aimed to develop new warfarin algorithms suitable to predict the stable warfarin dose for the Chinese population and to compare their prediction performance with those of the most commonly used algorithms.

Method: Multiple linear regression analysis with the warfarin optimal dose (WOD), logarithm (log) WOD, 1/WOD, and [Formula: see text], respectively, as the dependent variables were performed to deduce a new warfarin algorithm (NEW-Warfarin).

Design, synthesis and activity evaluation of novel lesinurad analogues containing thienopyrimidinone or pyridine substructure as human urate transporter 1 inhibitors.

Urate Transporter 1 (URAT1) plays a crucial role in uric acid transport, making it an attractive target for the treatment of gout and hyperuricemia. As a representative URAT1 inhibitor, Lesinurad treat gout by promoting the uric acid excretion. However, its lower in vitro and in vivo activity should be highly attracted attention.

Discovery of Novel Bicyclic Imidazolopyridine-Containing Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Improved Efficacy and Favorable Druggability.

Lesinurad is a uricosuric agent for the treatment of hyperuricemia associated with gout, which was found lacking in efficacy and safety. Here, scaffold hopping and molecular hybridization were exploited to modify all the structural components of lesinurad, and 36 novel compounds bearing bicyclic imidazolopyridine core were obtained. In a mouse model of acute hyperuricemia, 29 compounds demonstrated increased serum uric acid (SUA)-reducing activity; SUA was treated with , , and about fourfold lower compared with that of lesinurad.

Copula-based exposure risk dynamic simulation of dual heavy metal mixed pollution accidents at the watershed scale.

Most heavy metal exposure and pollution results from multiple industrial activities, including metal processing in refineries, and microelectronics. These issues pose a great threat to human health, ecological balance, and even societal stability. During 2012-2017, China, in particular, faced the challenge of 23 heavy metals accidents, six of which were extraordinarily serious accidents.

A Bayesian Network-based risk dynamic simulation model for accidental water pollution discharge of mine tailings ponds at watershed-scale.

Mine tailings ponds that contain heavy metals are sources of potential risk to human security and ecosystem health. China particularly faces challenge of accidental water pollution risk from more than 8869 mine tailings ponds in serve by 2015, some of which are close to residential areas and other important infrastructures within 1 km downstream. To address watershed-scale risk assessment of accidental water pollution from mine tailings ponds, a Bayesian Network-based Risk Dynamic Simulation (BN-RDS) model was proposed to simulate "sources/stressors-receptors-endpoints" risk routes.

Acceptable Risk Analysis for Abrupt Environmental Pollution Accidents in Zhangjiakou City, China.

Abrupt environmental pollution accidents cause considerable damage worldwide to the ecological environment, human health, and property. The concept of acceptable risk aims to answer whether or not a given environmental pollution risk exceeds a societally determined criterion. This paper presents a case study on acceptable environmental pollution risk conducted through a questionnaire survey carried out between August and October 2014 in five representative districts and two counties of Zhangjiakou City, Hebei Province, China.

Accidental Water Pollution Risk Analysis of Mine Tailings Ponds in Guanting Reservoir Watershed, Zhangjiakou City, China.

Over the past half century, a surprising number of major pollution incidents occurred due to tailings dam failures. Most previous studies of such incidents comprised forensic analyses of environmental impacts after a tailings dam failure, with few considering the combined pollution risk before incidents occur at a watershed-scale. We therefore propose Watershed-scale Tailings-pond Pollution Risk Analysis (WTPRA), designed for multiple mine tailings ponds, stemming from previous watershed-scale accidental pollution risk assessments.

Land-use suitability analysis for urban development in Beijing.

Land-use suitability analyses are of considerable use in the planning of mega-cities. An Urban Development Land-use Suitability Mapping (UDLSM) approach has been constructed, based on opportunity and constraint criteria. Two Multi-criteria Evaluation (MCE) methods, the Ideal Point Method (IPM) and Ordered Weighted Averaging (OWA), were used to generate the opportunity map.

Tumor necrosis factor-α gene polymorphisms and risk of oral cancer: evidence from a meta-analysis.

Numerous studies have been conducted regarding association between TNF-α and oral cancer risk, but the results remain controversial. The present meta-analysis is performed to acquire a more precise estimation of relationships. Databases of Pubmed, the Cochrane library and the China National Knowledge Internet (CNKI) were retrieved until August 10, 2013.

[Tumor necrosis factor alpha-238G/A polymorphism and tuberculosis susceptibility: a meta-analysis].

Objective: A comprehensive meta-analysis was performed to investigate the relationship between TNF -238G/A polymorphism and tuberculosis susceptibility.

Methods: Tuberculosis, TB, mycobacteria, polymorphism, variant, mutation, susceptibility, tumor necrosis factor or, TNF, cytokine, and gene were used as key words both in Chinese and English to search all the published related articles in Pubmed, Embase, Web of science, Science Direct, Springer Link, EBSCO, Wanfang and Chinese Journal Full-text Database until October 2011. HWE test was performed in all the comparisons.

Association between tumor necrosis factor alpha-238G/a polymorphism and tuberculosis susceptibility: a meta-analysis study.

Background: Tumor necrosis factor alpha (TNF-α) plays a key role in the containment of tuberculosis. The relationship between the TNF -238G/A polymorphism and tuberculosis susceptibility remains inconclusive. A comprehensive meta-analysis was made to provide a more precise estimate of the relationship between them.

Tumor necrosis factor alpha -308G>A, -863C>A, -857C>T gene polymorphisms and tuberculosis susceptibility: a meta-analysis.

Background/aims: A large number of studies have shown that polymorphisms in the tumor necrosis factor-α (TNF-α, TNFA) gene are implicated in susceptibility to tuberculosis (TB). However, the results are inconsistent. We performed this meta-analysis to estimate the association between polymorphisms in the TNFA gene and TB susceptibility.